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Items: 9


Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1.

van den Boom J, Trusch F, Hoppstock L, Beuck C, Bayer P.

PLoS One. 2016 Mar 14;11(3):e0151431. doi: 10.1371/journal.pone.0151431. eCollection 2016.


Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein.

Sabiani S, Geppert T, Engelbrecht C, Kowarz E, Schneider G, Marschalek R.

EBioMedicine. 2015 Apr 16;2(5):386-95. doi: 10.1016/j.ebiom.2015.04.009. eCollection 2015 May.


Synthesis of triamino acid building blocks with different lipophilicities.

Maity J, Honcharenko D, Strömberg R.

PLoS One. 2015 Apr 14;10(4):e0124046. doi: 10.1371/journal.pone.0124046. eCollection 2015.


Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.

Dong Y, Van Tine BA, Oyama T, Wang PI, Cheng EH, Hsieh JJ.

Cell Res. 2014 Nov;24(11):1354-66. doi: 10.1038/cr.2014.129. Epub 2014 Sep 30.


Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells.

Bier C, Hecht R, Kunst L, Scheiding S, Wünsch D, Goesswein D, Schneider G, Krämer OH, Knauer SK, Stauber RH.

PLoS One. 2012;7(5):e34142. doi: 10.1371/journal.pone.0034142. Epub 2012 May 3.


A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.

Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH, Hsieh JJ.

Cancer Res. 2012 Feb 1;72(3):736-46. doi: 10.1158/0008-5472.CAN-11-2584. Epub 2011 Dec 13.


Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors.

Knauer SK, Fetz V, Rabenstein J, Friedl S, Hofmann B, Sabiani S, Schröder E, Kunst L, Proschak E, Thines E, Kindler T, Schneider G, Marschalek R, Stauber RH, Bier C.

PLoS One. 2011;6(5):e18253. doi: 10.1371/journal.pone.0018253. Epub 2011 May 25.


Cell-based analysis of structure-function activity of threonine aspartase 1.

Bier C, Knauer SK, Klapthor A, Schweitzer A, Rekik A, Krämer OH, Marschalek R, Stauber RH.

J Biol Chem. 2011 Jan 28;286(4):3007-17. doi: 10.1074/jbc.M110.161646. Epub 2010 Nov 17.


Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis.

Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ.

Cancer Res. 2010 Jul 1;70(13):5358-67. doi: 10.1158/0008-5472.CAN-10-0027. Epub 2010 Jun 1.

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