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Items: 18

1.

Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria.

Sun W, Weingarten RA, Xu M, Southall N, Dai S, Shinn P, Sanderson PE, Williamson PR, Frank KM, Zheng W.

Emerg Microbes Infect. 2016 Nov 9;5(11):e116. doi: 10.1038/emi.2016.123.

2.

Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening.

Calcaterra NE, Hoeppner DJ, Wei H, Jaffe AE, Maher BJ, Barrow JC.

Sci Rep. 2016 Feb 16;6:19976. doi: 10.1038/srep19976.

3.

Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.

Yu HB, Zou BY, Wang XL, Li M.

Acta Pharmacol Sin. 2016 Jan;37(1):111-23. doi: 10.1038/aps.2015.143.

4.

High throughput screening technologies for ion channels.

Yu HB, Li M, Wang WP, Wang XL.

Acta Pharmacol Sin. 2016 Jan;37(1):34-43. doi: 10.1038/aps.2015.108. Epub 2015 Dec 14. Review.

5.

Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.

Zhang H, Zou B, Du F, Xu K, Li M.

Mol Pharmacol. 2015 Feb;87(2):207-17. doi: 10.1124/mol.114.094789. Epub 2014 Nov 24.

6.

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.

Schultz ML, Tecedor L, Stein CS, Stamnes MA, Davidson BL.

PLoS One. 2014 May 2;9(5):e96647. doi: 10.1371/journal.pone.0096647. eCollection 2014 May 2.

7.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E.

J Exp Clin Cancer Res. 2013 Sep 19;32:68. doi: 10.1186/1756-9966-32-68.

8.

Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1.

Raphemot R, Kadakia RJ, Olsen ML, Banerjee S, Days E, Smith SS, Weaver CD, Denton JS.

Assay Drug Dev Technol. 2013 Nov-Dec;11(9-10):532-43. doi: 10.1089/adt.2013.544. Epub 2013 Nov 22.

9.

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.

Yasgar A, Furdas SD, Maloney DJ, Jadhav A, Jung M, Simeonov A.

PLoS One. 2012;7(9):e45594. doi: 10.1371/journal.pone.0045594. Epub 2012 Sep 20.

10.

Development and validation of an automated high-throughput system for zebrafish in vivo screenings.

Letamendia A, Quevedo C, Ibarbia I, Virto JM, Holgado O, Diez M, Izpisua Belmonte JC, Callol-Massot C.

PLoS One. 2012;7(5):e36690. doi: 10.1371/journal.pone.0036690. Epub 2012 May 15.

11.

Paradigm shift in toxicity testing and modeling.

Sun H, Xia M, Austin CP, Huang R.

AAPS J. 2012 Sep;14(3):473-80. doi: 10.1208/s12248-012-9358-1. Epub 2012 Apr 20. Review.

12.

Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.

Raphemot R, Lonergan DF, Nguyen TT, Utley T, Lewis LM, Kadakia R, Weaver CD, Gogliotti R, Hopkins C, Lindsley CW, Denton JS.

Front Pharmacol. 2011 Nov 30;2:75. doi: 10.3389/fphar.2011.00075. eCollection 2011 Nov 30.

13.

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP.

Toxicol Appl Pharmacol. 2011 May 1;252(3):250-8. doi: 10.1016/j.taap.2011.02.016. Epub 2011 Feb 26.

14.

Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.

Zou B, Yu H, Babcock JJ, Chanda P, Bader JS, McManus OB, Li M.

Assay Drug Dev Technol. 2010 Dec;8(6):743-54. doi: 10.1089/adt.2010.0339.

15.

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL.

Assay Drug Dev Technol. 2010 Dec;8(6):727-42. doi: 10.1089/adt.2010.0331.

16.

The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.

Shukla SJ, Huang R, Austin CP, Xia M.

Drug Discov Today. 2010 Dec;15(23-24):997-1007. doi: 10.1016/j.drudis.2010.07.007. Epub 2010 Aug 11. Review.

17.

Analysis of plasma membrane integrity by fluorescent detection of Tl(+) uptake.

Bowman AM, Nesin OM, Pakhomova ON, Pakhomov AG.

J Membr Biol. 2010 Jul;236(1):15-26. doi: 10.1007/s00232-010-9269-y. Epub 2010 Jul 11.

18.

Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.

Bhave G, Lonergan D, Chauder BA, Denton JS.

Future Med Chem. 2010 May;2(5):757-74. doi: 10.4155/fmc.10.179. Review.

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