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Items: 16


FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).

Shao W, Zumer K, Fujinaga K, Peterlin BM.

J Biol Chem. 2016 Aug 19;291(34):17953-63. doi: 10.1074/jbc.M116.724401. Epub 2016 Jun 30.


The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.

Le Clorennec C, Lazrek Y, Dubreuil O, Larbouret C, Poul MA, Mondon P, Melino G, Pèlegrin A, Chardès T.

Oncotarget. 2016 Jun 14;7(24):37013-37029. doi: 10.18632/oncotarget.9455.


Novel somatic mutations identified by whole-exome sequencing in muscle-invasive transitional cell carcinoma of the bladder.

Pan H, Xu X, Wu D, Qiu Q, Zhou S, He X, Zhou Y, Qu P, Hou J, He J, Zhou J.

Oncol Lett. 2016 Feb;11(2):1486-1492. Epub 2016 Jan 8.


Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma.

Zhang XF, Chao J, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Jiang SS, Chen CL, Zhang HX, Xia JC.

Oncotarget. 2015 Dec 1;6(38):40920-33. doi: 10.18632/oncotarget.5712.


Knockdown of WWP1 inhibits growth and invasion, but induces apoptosis of osteosarcoma cells.

Wu Z, Zan P, Li S, Liu J, Wang J, Chen D, Wang H, Qian Y, Luo L, Huang X.

Int J Clin Exp Pathol. 2015 Jul 1;8(7):7869-77. eCollection 2015.


Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors.

Kang G, Yun H, Sun CH, Park I, Lee S, Kwon J, Do I, Hong ME, Van Vrancken M, Lee J, Park JO, Cho J, Kim KM, Sohn TS.

Oncotarget. 2016 Feb 9;7(6):6538-51. doi: 10.18632/oncotarget.3731.


Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.

Farooq A.

Exp Biol Med (Maywood). 2015 Mar;240(3):361-74. doi: 10.1177/1535370214561586. Epub 2015 Feb 7. Review.


Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase.

Schuchardt BJ, Bhat V, Mikles DC, McDonald CB, Sudol M, Farooq A.

Biochemistry. 2013 Dec 23;52(51):9223-36. doi: 10.1021/bi400987k. Epub 2013 Dec 13.


WW domain containing E3 ubiquitin protein ligase 1 (WWP1) negatively regulates TLR4-mediated TNF-α and IL-6 production by proteasomal degradation of TNF receptor associated factor 6 (TRAF6).

Lin XW, Xu WC, Luo JG, Guo XJ, Sun T, Zhao XL, Fu ZJ.

PLoS One. 2013 Jun 17;8(6):e67633. doi: 10.1371/journal.pone.0067633. Print 2013.


Endocytosis of receptor tyrosine kinases.

Goh LK, Sorkin A.

Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a017459. doi: 10.1101/cshperspect.a017459. Review.


WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.

Yeung B, Ho KC, Yang X.

PLoS One. 2013;8(4):e61027. doi: 10.1371/journal.pone.0061027. Epub 2013 Apr 3.


Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity.

Zaarour RF, Chirivino D, Del Maestro L, Daviet L, Atfi A, Louvard D, Arpin M.

PLoS One. 2012;7(5):e37490. doi: 10.1371/journal.pone.0037490. Epub 2012 May 22.


WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts.

Cao X, Xue L, Han L, Ma L, Chen T, Tong T.

J Biol Chem. 2011 Sep 23;286(38):33447-56. doi: 10.1074/jbc.M111.225565. Epub 2011 Jul 27.


Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.

Chong PA, Lin H, Wrana JL, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18404-9. doi: 10.1073/pnas.1003023107. Epub 2010 Oct 11.


E3 ubiquitin ligases in ErbB receptor quantity control.

Carraway KL 3rd.

Semin Cell Dev Biol. 2010 Dec;21(9):936-43. doi: 10.1016/j.semcdb.2010.09.006. Epub 2010 Sep 22. Review.

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