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Items: 1 to 20 of 22

1.

Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications.

Bunik V, Artiukhov A, Aleshin V, Mkrtchyan G.

Biology (Basel). 2016 Dec 14;5(4). pii: E53. Review.

2.

Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening.

Park YD, Sun W, Salas A, Antia A, Carvajal C, Wang A, Xu X, Meng Z, Zhou M, Tawa GJ, Dehdashti J, Zheng W, Henderson CM, Zelazny AM, Williamson PR.

MBio. 2016 Aug 2;7(4). pii: e01073-16. doi: 10.1128/mBio.01073-16.

3.

Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase.

Chan KX, Mabbitt PD, Phua SY, Mueller JW, Nisar N, Gigolashvili T, Stroeher E, Grassl J, Arlt W, Estavillo GM, Jackson CJ, Pogson BJ.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4567-76. doi: 10.1073/pnas.1604936113. Epub 2016 Jul 18.

4.

Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C.

J Biol Chem. 2016 Apr 29;291(18):9776-84. doi: 10.1074/jbc.M115.708255. Epub 2016 Mar 9.

PMID:
26961873
5.

Dysregulated metabolism contributes to oncogenesis.

Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE; Target Validation Team..

Semin Cancer Biol. 2015 Dec;35 Suppl:S129-50. doi: 10.1016/j.semcancer.2015.10.002. Epub 2015 Oct 8. Review.

6.

Purification, crystallization and preliminary X-ray diffraction analysis of NADP-dependent glutamate dehydrogenase from Aspergillus niger.

Prakash P, Walvekar AS, Punekar NS, Bhaumik P.

Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1508-12. doi: 10.1107/S2053230X14021499. Epub 2014 Oct 25.

7.

Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia.

Chandran S, Yap F, Hussain K.

World J Diabetes. 2014 Oct 15;5(5):666-77. doi: 10.4239/wjd.v5.i5.666. Review.

8.

Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).

Botman D, Tigchelaar W, Van Noorden CJ.

J Histochem Cytochem. 2014 Nov;62(11):802-12. doi: 10.1369/0022155414549071. Epub 2014 Aug 13.

9.

In silico prediction of antimalarial drug target candidates.

Ludin P, Woodcroft B, Ralph SA, Mäser P.

Int J Parasitol Drugs Drug Resist. 2012 Jul 17;2:191-9. doi: 10.1016/j.ijpddr.2012.07.002. eCollection 2012 Dec.

10.

Antibacterial mechanisms identified through structural systems pharmacology.

Chang RL, Xie L, Bourne PE, Palsson BO.

BMC Syst Biol. 2013 Oct 10;7:102. doi: 10.1186/1752-0509-7-102.

11.

Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes.

Whitelaw BS, Robinson MB.

Front Endocrinol (Lausanne). 2013 Sep 17;4:123. doi: 10.3389/fendo.2013.00123. eCollection 2013.

12.

Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism.

Zhang T, Li C.

Acta Biochim Biophys Sin (Shanghai). 2013 Jan;45(1):36-43. doi: 10.1093/abbs/gms107. Epub 2012 Dec 4. Review.

13.

Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.

van der Schaar HM, van der Linden L, Lanke KH, Strating JR, Pürstinger G, de Vries E, de Haan CA, Neyts J, van Kuppeveld FJ.

Cell Res. 2012 Nov;22(11):1576-92. doi: 10.1038/cr.2012.129. Epub 2012 Sep 4.

14.

A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.

Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL.

Antiviral Res. 2012 Oct;96(1):70-81. doi: 10.1016/j.antiviral.2012.07.012. Epub 2012 Aug 7.

15.

Binding leverage as a molecular basis for allosteric regulation.

Mitternacht S, Berezovsky IN.

PLoS Comput Biol. 2011 Sep;7(9):e1002148. doi: 10.1371/journal.pcbi.1002148. Epub 2011 Sep 15.

16.

Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase.

Tomita T, Kuzuyama T, Nishiyama M.

J Biol Chem. 2011 Oct 28;286(43):37406-13. doi: 10.1074/jbc.M111.260265. Epub 2011 Sep 6.

17.

Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site.

Li C, Li M, Chen P, Narayan S, Matschinsky FM, Bennett MJ, Stanley CA, Smith TJ.

J Biol Chem. 2011 Sep 30;286(39):34164-74. doi: 10.1074/jbc.M111.268599. Epub 2011 Aug 3.

18.

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons.

Ramsden N, Perrin J, Ren Z, Lee BD, Zinn N, Dawson VL, Tam D, Bova M, Lang M, Drewes G, Bantscheff M, Bard F, Dawson TM, Hopf C.

ACS Chem Biol. 2011 Oct 21;6(10):1021-8. doi: 10.1021/cb2002413. Epub 2011 Aug 10.

19.

A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.

Bailey J, Powell L, Sinanan L, Neal J, Li M, Smith T, Bell E.

FEBS J. 2011 Sep;278(17):3140-51. doi: 10.1111/j.1742-4658.2011.08240.x. Epub 2011 Aug 11.

20.

Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression.

Michaelis EK, Wang X, Pal R, Bao X, Hascup KN, Wang Y, Wang WT, Hui D, Agbas A, Choi IY, Belousov A, Gerhardt GA.

Neurochem Int. 2011 Sep;59(4):473-81. doi: 10.1016/j.neuint.2011.03.003. Epub 2011 Mar 17.

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