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Items: 1 to 20 of 97


Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded.

Wrenbeck EE, Azouz LR, Whitehead TA.

Nat Commun. 2017 Jun 6;8:15695. doi: 10.1038/ncomms15695.


Thermostabilization of the uronate dehydrogenase from Agrobacterium tumefaciens by semi-rational design.

Roth T, Beer B, Pick A, Sieber V.

AMB Express. 2017 Dec;7(1):103. doi: 10.1186/s13568-017-0405-2. Epub 2017 May 23.


Thermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designed.

Carlin DA, Hapig-Ward S, Chan BW, Damrau N, Riley M, Caster RW, Bethards B, Siegel JB.

PLoS One. 2017 May 22;12(5):e0176255. doi: 10.1371/journal.pone.0176255. eCollection 2017.


Experimental recreation of the evolution of lignin-degrading enzymes from the Jurassic to date.

Ayuso-Fernández I, Martínez AT, Ruiz-Dueñas FJ.

Biotechnol Biofuels. 2017 Mar 16;10:67. doi: 10.1186/s13068-017-0744-x. eCollection 2017.


Dynamic New World: Refining Our View of Protein Structure, Function and Evolution.

Mannige RV.

Proteomes. 2014 Mar 7;2(1):128-153. doi: 10.3390/proteomes2010128. Review.


Adaptive multiscapes: an up-to-date metaphor to visualize molecular adaptation.

Catalán P, Arias CF, Cuesta JA, Manrubia S.

Biol Direct. 2017 Feb 28;12(1):7. doi: 10.1186/s13062-017-0178-1.


Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.

Kumar A, Natarajan C, Moriyama H, Witt CC, Weber RE, Fago A, Storz JF.

Mol Biol Evol. 2017 May 1;34(5):1240-1251. doi: 10.1093/molbev/msx085.


When directed evolution met ancestral enzyme resurrection.

Alcalde M.

Microb Biotechnol. 2017 Jan;10(1):22-24. doi: 10.1111/1751-7915.12452. Epub 2016 Nov 11.


Ultrahigh-throughput-directed enzyme evolution by absorbance-activated droplet sorting (AADS).

Gielen F, Hours R, Emond S, Fischlechner M, Schell U, Hollfelder F.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7383-E7389. Epub 2016 Nov 7.


Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native Activity.

Kaltenbach M, Emond S, Hollfelder F, Tokuriki N.

PLoS Genet. 2016 Oct 7;12(10):e1006305. doi: 10.1371/journal.pgen.1006305. eCollection 2016 Oct.


Using Evolution to Guide Protein Engineering: The Devil IS in the Details.

Swint-Kruse L.

Biophys J. 2016 Jul 12;111(1):10-8. doi: 10.1016/j.bpj.2016.05.030. Review.


Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.

Frago S, Nicholls RD, Strickland M, Hughes J, Williams C, Garner L, Surakhy M, Maclean R, Rezgui D, Prince SN, Zaccheo OJ, Ebner D, Sanegre S, Yu S, Buffa FM, Crump MP, Hassan AB.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2766-75. doi: 10.1073/pnas.1513023113. Epub 2016 May 2.


Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein.

Gupta A, Adami C.

PLoS Genet. 2016 Mar 30;12(3):e1005960. doi: 10.1371/journal.pgen.1005960. eCollection 2016 Mar.


Causes of molecular convergence and parallelism in protein evolution.

Storz JF.

Nat Rev Genet. 2016 Apr;17(4):239-50. doi: 10.1038/nrg.2016.11. Epub 2016 Mar 14. Review.


Environmental changes bridge evolutionary valleys.

Steinberg B, Ostermeier M.

Sci Adv. 2016 Jan 22;2(1):e1500921. doi: 10.1126/sciadv.1500921. eCollection 2016 Jan.


Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.

Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):326-31. doi: 10.1073/pnas.1518960113. Epub 2015 Dec 29.


Evolving new protein-protein interaction specificity through promiscuous intermediates.

Aakre CD, Herrou J, Phung TN, Perchuk BS, Crosson S, Laub MT.

Cell. 2015 Oct 22;163(3):594-606. doi: 10.1016/j.cell.2015.09.055. Epub 2015 Oct 17.


Focused Directed Evolution of Aryl-Alcohol Oxidase in Saccharomyces cerevisiae by Using Chimeric Signal Peptides.

Viña-Gonzalez J, Gonzalez-Perez D, Ferreira P, Martinez AT, Alcalde M.

Appl Environ Microbiol. 2015 Sep;81(18):6451-62. doi: 10.1128/AEM.01966-15. Epub 2015 Jul 10.


Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites.

Anderson DW, McKeown AN, Thornton JW.

Elife. 2015 Jun 15;4:e07864. doi: 10.7554/eLife.07864.


Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability.

Mehta SC, Rice K, Palzkill T.

PLoS Pathog. 2015 Jun 1;11(6):e1004949. doi: 10.1371/journal.ppat.1004949. eCollection 2015 Jun.

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