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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

Jáuregui P, Landau NR.

Sci Rep. 2018 Mar 7;8(1):4153. doi: 10.1038/s41598-018-22432-4.


The SAM domain of mouse SAMHD1 is critical for its activation and regulation.

Buzovetsky O, Tang C, Knecht KM, Antonucci JM, Wu L, Ji X, Xiong Y.

Nat Commun. 2018 Jan 29;9(1):411. doi: 10.1038/s41467-017-02783-8.


A game of substrates: replication fork remodeling and its roles in genome stability and chemo-resistance.

Sidorova J.

Cell Stress. 2017 Dec;1(3):115-133. doi: 10.15698/cst2017.12.114. Epub 2017 Dec 5.


Interferons: Reprogramming the Metabolic Network against Viral Infection.

Raniga K, Liang C.

Viruses. 2018 Jan 13;10(1). pii: E36. doi: 10.3390/v10010036. Review.


A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature.

Oh C, Ryoo J, Park K, Kim B, Daly MB, Cho D, Ahn K.

Sci Rep. 2018 Jan 8;8(1):84. doi: 10.1038/s41598-017-18308-8.


Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes.

Nyalwidhe JO, Gallagher GR, Glenn LM, Morris MA, Vangala P, Jurczyk A, Bortell R, Harlan DM, Wang JP, Nadler JL.

J Endocr Soc. 2017 Sep 11;1(10):1272-1286. doi: 10.1210/js.2017-00278. eCollection 2017 Oct 1. Erratum in: J Endocr Soc. 2018 Jan 12;2(2):134.


The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response.

Antonucci JM, St Gelais C, Wu L.

Front Immunol. 2017 Nov 10;8:1541. doi: 10.3389/fimmu.2017.01541. eCollection 2017. Review.


Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

Sumner RP, Thorne LG, Fink DL, Khan H, Milne RS, Towers GJ.

Front Immunol. 2017 Oct 6;8:1246. doi: 10.3389/fimmu.2017.01246. eCollection 2017. Review.


SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.

Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS.

Cell Rep. 2017 Aug 22;20(8):1921-1935. doi: 10.1016/j.celrep.2017.08.008.


Neonatal detection of Aicardi Goutières Syndrome by increased C26:0 lysophosphatidylcholine and interferon signature on newborn screening blood spots.

Armangue T, Orsini JJ, Takanohashi A, Gavazzi F, Conant A, Ulrick N, Morrissey MA, Nahhas N, Helman G, Gordish-Dressman H, Orcesi S, Tonduti D, Stutterd C, van Haren K, Toro C, Iglesias AD, van der Knaap MS, Goldbach Mansky R, Moser AB, Jones RO, Vanderver A.

Mol Genet Metab. 2017 Nov;122(3):134-139. doi: 10.1016/j.ymgme.2017.07.006. Epub 2017 Jul 20.


AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA.

Nakaya Y, Lilue J, Stavrou S, Moran EA, Ross SR.

MBio. 2017 Jul 5;8(4). pii: e00944-17. doi: 10.1128/mBio.00944-17.


Regulating STING in health and disease.

Li Y, Wilson HL, Kiss-Toth E.

J Inflamm (Lond). 2017 Jun 7;14:11. doi: 10.1186/s12950-017-0159-2. eCollection 2017. Review.


MDA5-Associated Neuroinflammation and the Singleton-Merten Syndrome: Two Faces of the Same Type I Interferonopathy Spectrum.

Buers I, Rice GI, Crow YJ, Rutsch F.

J Interferon Cytokine Res. 2017 May;37(5):214-219. doi: 10.1089/jir.2017.0004. Review.


SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.

Herold N, Rudd SG, Sanjiv K, Kutzner J, Bladh J, Paulin CBJ, Helleday T, Henter JI, Schaller T.

Cell Cycle. 2017 Jun 3;16(11):1029-1038. doi: 10.1080/15384101.2017.1314407. Epub 2017 Apr 24.


The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.

Mauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW, Hollis T.

Antioxid Redox Signal. 2017 Dec 1;27(16):1317-1331. doi: 10.1089/ars.2016.6888. Epub 2017 Apr 18.


Tocilizumab reverses cerebral vasculopathy in a patient with homozygous SAMHD1 mutation.

Henrickson M, Wang H.

Clin Rheumatol. 2017 Jun;36(6):1445-1451. doi: 10.1007/s10067-017-3600-2. Epub 2017 Mar 13. Review.


A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.

White TE, Brandariz-Nuñez A, Martinez-Lopez A, Knowlton C, Lenzi G, Kim B, Ivanov D, Diaz-Griffero F.

Hum Mutat. 2017 Jun;38(6):658-668. doi: 10.1002/humu.23201. Epub 2017 May 2.


Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.

Wang H, Guo H, Su J, Rui Y, Zheng W, Gao W, Zhang W, Li Z, Liu G, Markham RB, Wei W, Yu XF.

J Virol. 2017 Apr 13;91(9). pii: e00225-17. doi: 10.1128/JVI.00225-17. Print 2017 May 1.


Different Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State.

Calonge E, Bermejo M, Diez-Fuertes F, Mangeot I, González N, Coiras M, Jiménez Tormo L, García-Perez J, Dereuddre-Bosquet N, Le Grand R, Alcamí J.

J Virol. 2017 Mar 29;91(8). pii: e01379-16. doi: 10.1128/JVI.01379-16. Print 2017 Apr 15.


A Critical Balance: dNTPs and the Maintenance of Genome Stability.

Pai CC, Kearsey SE.

Genes (Basel). 2017 Jan 31;8(2). pii: E57. doi: 10.3390/genes8020057. Review.

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