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Items: 1 to 20 of 101

1.

Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K.

Kwon KW, Kim WS, Kim H, Han SJ, Hahn MY, Lee JS, Nam KT, Cho SN, Shin SJ.

Sci Rep. 2017 Mar 8;7:44151. doi: 10.1038/srep44151.

2.

Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct.

Burel JG, Apte SH, Groves PL, McCarthy JS, Doolan DL.

JCI Insight. 2017 Feb 9;2(3):e87499. doi: 10.1172/jci.insight.87499.

3.

Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants.

Olafsdottir TA, Lindqvist M, Nookaew I, Andersen P, Maertzdorf J, Persson J, Christensen D, Zhang Y, Anderson J, Khoomrung S, Sen P, Agger EM, Coler R, Carter D, Meinke A, Rappuoli R, Kaufmann SH, Reed SG, Harandi AM.

Sci Rep. 2016 Dec 13;6:39097. doi: 10.1038/srep39097.

4.

Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations.

Sharpe S, White A, Sarfas C, Sibley L, Gleeson F, McIntyre A, Basaraba R, Clark S, Hall G, Rayner E, Williams A, Marsh PD, Dennis M.

Tuberculosis (Edinb). 2016 Dec;101:174-190. doi: 10.1016/j.tube.2016.09.004. Epub 2016 Oct 8.

5.

Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine.

Nyendak M, Swarbrick GM, Duncan A, Cansler M, Huff EW, Hokey D, Evans T, Barker L, Blatner G, Sadoff J, Douoguih M, Pau MG, Lewinsohn DA, Lewinsohn DM.

Sci Rep. 2016 Nov 2;6:36355. doi: 10.1038/srep36355.

6.

Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis.

Bhattacharya P, Dey R, Dagur PK, Joshi AB, Ismail N, Gannavaram S, Debrabant A, Akue AD, KuKuruga MA, Selvapandiyan A, McCoy JP Jr, Nakhasi HL.

PLoS Negl Trop Dis. 2016 Aug 31;10(8):e0004963. doi: 10.1371/journal.pntd.0004963. eCollection 2016 Aug.

7.

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung.

Woodworth JS, Cohen SB, Moguche AO, Plumlee CR, Agger EM, Urdahl KB, Andersen P.

Mucosal Immunol. 2017 Mar;10(2):555-564. doi: 10.1038/mi.2016.70. Epub 2016 Aug 24.

8.

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis.

Billeskov R, Tan EV, Cang M, Abalos RM, Burgos J, Pedersen BV, Christensen D, Agger EM, Andersen P.

PLoS One. 2016 Aug 15;11(8):e0161217. doi: 10.1371/journal.pone.0161217. eCollection 2016.

9.

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection.

Sayes F, Pawlik A, Frigui W, Gröschel MI, Crommelynck S, Fayolle C, Cia F, Bancroft GJ, Bottai D, Leclerc C, Brosch R, Majlessi L.

PLoS Pathog. 2016 Jul 28;12(7):e1005770. doi: 10.1371/journal.ppat.1005770. eCollection 2016 Jul.

10.

Tuberculosis Biomarkers: From Diagnosis to Protection.

Goletti D, Petruccioli E, Joosten SA, Ottenhoff TH.

Infect Dis Rep. 2016 Jun 24;8(2):6568. doi: 10.4081/idr.2016.6568. eCollection 2016 Jun 24. Review.

11.

Nonclassical MHC Ib-restricted CD8+ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection.

Shang S, Siddiqui S, Bian Y, Zhao J, Wang CR.

PLoS Pathog. 2016 Jun 7;12(6):e1005688. doi: 10.1371/journal.ppat.1005688. eCollection 2016 Jun.

12.

The mc2-CMX vaccine induces an enhanced immune response against Mycobacterium tuberculosis compared to Bacillus Calmette-Guérin but with similar lung inflammatory effects.

Oliveira FM, Trentini MM, Junqueira-Kipnis AP, Kipnis A.

Mem Inst Oswaldo Cruz. 2016 Apr;111(4):223-31. doi: 10.1590/0074-02760150411.

13.

Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10.

Jagannathan P, Bowen K, Nankya F, McIntyre TI, Auma A, Wamala S, Sikyomu E, Naluwu K, Nalubega M, Boyle MJ, Farrington LA, Bigira V, Kapisi J, Aweeka F, Greenhouse B, Kamya M, Dorsey G, Feeney ME.

J Infect Dis. 2016 Jul 15;214(2):329-38. doi: 10.1093/infdis/jiw147. Epub 2016 Apr 10.

PMID:
27067196
14.

The Secreted Protein Rv1860 of Mycobacterium tuberculosis Stimulates Human Polyfunctional CD8+ T Cells.

Satchidanandam V, Kumar N, Biswas S, Jumani RS, Jain C, Rani R, Aggarwal B, Singh J, Kotnur MR, Sridharan A.

Clin Vaccine Immunol. 2016 Apr 4;23(4):282-93. doi: 10.1128/CVI.00554-15. Print 2016 Apr.

15.

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens.

Knudsen NP, Olsen A, Buonsanti C, Follmann F, Zhang Y, Coler RN, Fox CB, Meinke A, D'Oro U, Casini D, Bonci A, Billeskov R, De Gregorio E, Rappuoli R, Harandi AM, Andersen P, Agger EM.

Sci Rep. 2016 Jan 21;6:19570. doi: 10.1038/srep19570.

16.

IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.

Popescu I, Pipeling MR, Mannem H, Shah PD, Orens JB, Connors M, Migueles SA, McDyer JF.

J Immunol. 2016 Jan 15;196(2):877-90. doi: 10.4049/jimmunol.1501589. Epub 2015 Dec 11.

17.

Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses.

Santana VC, Almeida RR, Ribeiro SP, Ferreira LC, Kalil J, Rosa DS, Cunha-Neto E.

Mem Inst Oswaldo Cruz. 2015 Dec;110(8):1010-6. doi: 10.1590/0074-02760150283. Epub 2015 Nov 24.

18.

Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates.

Agger EM.

Adv Drug Deliv Rev. 2016 Jul 1;102:73-82. doi: 10.1016/j.addr.2015.11.012. Epub 2015 Nov 17. Review.

PMID:
26596558
19.

Characterization of the Antigen-Specific CD4(+) T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes.

Ciabattini A, Prota G, Christensen D, Andersen P, Pozzi G, Medaglini D.

Front Immunol. 2015 Aug 28;6:430. doi: 10.3389/fimmu.2015.00430. eCollection 2015.

20.

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.

Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM.

J Exp Med. 2015 Aug 24;212(9):1449-63. doi: 10.1084/jem.20141520. Epub 2015 Aug 17.

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