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Items: 10

1.

Imaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe.

Gilchrist ML, Ahn K, Li YM.

Anal Chem. 2016 Jan 19;88(2):1303-11. doi: 10.1021/acs.analchem.5b03762. Epub 2016 Jan 6.

2.

Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.

Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM.

Cell Rep. 2014 Aug 21;8(4):1077-92. doi: 10.1016/j.celrep.2014.07.028. Epub 2014 Aug 14.

3.

Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE.

Biochemistry. 2014 Feb 4;53(4):702-13. doi: 10.1021/bi401537v. Epub 2014 Jan 22.

4.

Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.

Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X.

Nat Immunol. 2012 May 20;13(7):642-50. doi: 10.1038/ni.2304.

5.

Development of clickable active site-directed photoaffinity probes for γ-secretase.

Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2997-3000. doi: 10.1016/j.bmcl.2012.02.027. Epub 2012 Feb 20.

6.

Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.

Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF.

Cell. 2011 Oct 28;147(3):615-28. doi: 10.1016/j.cell.2011.09.036.

7.

Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.

Meckler X, Roseman J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, Thinakaran G.

J Neurosci. 2010 Dec 1;30(48):16160-9. doi: 10.1523/JNEUROSCI.4436-10.2010.

8.

Activation and intrinsic gamma-secretase activity of presenilin 1.

Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21435-40. doi: 10.1073/pnas.1013246107. Epub 2010 Nov 29.

9.

Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.

Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, Li Y, Hu X, Ivashkiv LB.

J Immunol. 2010 Nov 1;185(9):5023-31. doi: 10.4049/jimmunol.1001544. Epub 2010 Sep 24.

10.

Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.

Tian Y, Crump CJ, Li YM.

J Biol Chem. 2010 Oct 15;285(42):32549-56. doi: 10.1074/jbc.M110.128439. Epub 2010 Jul 30.

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