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Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update.

Newton R, Giembycz MA.

Br J Pharmacol. 2016 Dec;173(24):3405-3430. doi: 10.1111/bph.13628. Review.


GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism.

Young A, Dandekar U, Pan C, Sader A, Zheng JJ, Lewis RA, Farber DB.

PLoS One. 2016 Sep 8;11(9):e0162273. doi: 10.1371/journal.pone.0162273.


Inhibition of the Binding between RGS2 and β-Tubulin Interferes with Spindle Formation and Chromosome Segregation during Mouse Oocyte Maturation In Vitro.

Jiang MX, Shi Y, Sun ZG, Zhang Z, Zhu Y.

PLoS One. 2016 Jul 27;11(7):e0159535. doi: 10.1371/journal.pone.0159535.


Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY.

Taylor VG, Bommarito PA, Tesmer JJ.

J Biol Chem. 2016 Mar 4;291(10):5138-45. doi: 10.1074/jbc.M115.712075.


A proteomic view to characterize the effect of chitosan nanoparticle to hepatic cells: is chitosan nanoparticle an enhancer of PI3K/AKT1/mTOR pathway?

Yang MH, Yuan SS, Huang YF, Lin PC, Lu CY, Chung TW, Tyan YC.

Biomed Res Int. 2014;2014:789591. doi: 10.1155/2014/789591.


Transcriptome analyses and differential gene expression in a non-model fish species with alternative mating tactics.

Schunter C, Vollmer SV, Macpherson E, Pascual M.

BMC Genomics. 2014 Feb 28;15:167. doi: 10.1186/1471-2164-15-167.


Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

Munro TA, Huang XP, Inglese C, Perrone MG, Van't Veer A, Carroll FI, Béguin C, Carlezon WA Jr, Colabufo NA, Cohen BM, Roth BL.

PLoS One. 2013 Aug 14;8(8):e70701. doi: 10.1371/journal.pone.0070701.


RGS21, a regulator of taste and mucociliary clearance?

Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP.

Laryngoscope. 2014 Mar;124(3):E56-63. doi: 10.1002/lary.24326.


A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates.

Park CR, Moon MJ, Park S, Kim DK, Cho EB, Millar RP, Hwang JI, Seong JY.

PLoS One. 2013 Jun 11;8(6):e65420. doi: 10.1371/journal.pone.0065420.


Structural and functional analysis of the regulator of G protein signaling 2-gαq complex.

Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ.

Structure. 2013 Mar 5;21(3):438-48. doi: 10.1016/j.str.2012.12.016.


A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.

Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, Caron MG, Calakos N, Roth BL.

Neuropsychopharmacology. 2013 Apr;38(5):854-62. doi: 10.1038/npp.2012.251.


Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.

Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G Jr, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ.

J Biol Chem. 2012 Dec 7;287(50):41706-19. doi: 10.1074/jbc.M112.423806.


Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.

Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC.

Nature. 2012 May 16;485(7398):395-9. doi: 10.1038/nature11085.


A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome.

Rieder MJ, Green GE, Park SS, Stamper BD, Gordon CT, Johnson JM, Cunniff CM, Smith JD, Emery SB, Lyonnet S, Amiel J, Holder M, Heggie AA, Bamshad MJ, Nickerson DA, Cox TC, Hing AV, Horst JA, Cunningham ML.

Am J Hum Genet. 2012 May 4;90(5):907-14. doi: 10.1016/j.ajhg.2012.04.002. Erratum in: Am J Hum Genet. 2012 Jun 8;90(6):1116. Am J Hum Genet. 2012 Aug 10;91(2):397.


A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.

Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP.

PLoS Pathog. 2012 Feb;8(2):e1002553. doi: 10.1371/journal.ppat.1002553.


Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.

Osei-Owusu P, Sabharwal R, Kaltenbronn KM, Rhee MH, Chapleau MW, Dietrich HH, Blumer KJ.

J Biol Chem. 2012 Apr 6;287(15):12541-9. doi: 10.1074/jbc.M111.332130.


β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108.


Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.

Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, Caron MG, Javitch JA, Roth BL, Jin J.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. doi: 10.1073/pnas.1104807108.


Regulators of G-protein signaling in the heart and their potential as therapeutic targets.

Zhang P, Mende U.

Circ Res. 2011 Jul 22;109(3):320-33. doi: 10.1161/CIRCRESAHA.110.231423. Review.


Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.

Kimple AJ, Bosch DE, Giguère PM, Siderovski DP.

Pharmacol Rev. 2011 Sep;63(3):728-49. doi: 10.1124/pr.110.003038. Review.

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