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Detection of a combination of serum IgG and IgA antibodies against selected mycobacterial targets provides promising diagnostic signatures for active TB.

Awoniyi DO, Baumann R, Chegou NN, Kriel B, Jacobs R, Kidd M, Loxton AG, Kaempfer S, Singh M, Walzl G.

Oncotarget. 2017 Jun 6;8(23):37525-37537. doi: 10.18632/oncotarget.16401.


How to manage TB in children? Problems and solutions in four cases.

Buonsenso D, Serranti D, Focarelli B, Chiaretti A, Calzedda R, Valentini P.

Open Med (Wars). 2014 Nov 3;10(1):63-69. doi: 10.1515/med-2015-0012. eCollection 2015.


Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection.

De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R.

J Clin Microbiol. 2017 Feb;55(2):391-402. doi: 10.1128/JCM.01646-16. Epub 2016 Nov 16. Erratum in: J Clin Microbiol. 2017 May;55(5):1598.


Cytokine Patterns in Tuberculosis Infection; IL-1ra, IL-2 and IP-10 Differentiate Borderline QuantiFERON-TB Samples from Uninfected Controls.

Wergeland I, Assmus J, Dyrhol-Riise AM.

PLoS One. 2016 Sep 29;11(9):e0163848. doi: 10.1371/journal.pone.0163848. eCollection 2016.


Combined Analysis of IFN-γ, IL-2, IL-5, IL-10, IL-1RA and MCP-1 in QFT Supernatant Is Useful for Distinguishing Active Tuberculosis from Latent Infection.

Suzukawa M, Akashi S, Nagai H, Nagase H, Nakamura H, Matsui H, Hebisawa A, Ohta K.

PLoS One. 2016 Apr 1;11(4):e0152483. doi: 10.1371/journal.pone.0152483. eCollection 2016.


Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis.

Lee SW, Wu LS, Huang GM, Huang KY, Lee TY, Weng JT.

BMC Bioinformatics. 2016 Jan 11;17 Suppl 1:3. doi: 10.1186/s12859-015-0848-x.


Post-treatment change in Mycobacterium tuberculosis antigen-stimulated tumor necrosis factor-alpha release in patients with active tuberculosis.

Kim CH, Yoo SS, Lee SY, Cha SI, Park JY, Lee J.

J Thorac Dis. 2015 May;7(5):903-7. doi: 10.3978/j.issn.2072-1439.2015.05.08.


Evaluation of antigen-specific immunoglobulin g responses in pulmonary tuberculosis patients and contacts.

Hur YG, Kim A, Kang YA, Kim AS, Kim DY, Kim Y, Kim Y, Lee H, Cho SN.

J Clin Microbiol. 2015 Mar;53(3):904-9. doi: 10.1128/JCM.03050-14. Epub 2015 Jan 14.


Clinical immunology and multiplex biomarkers of human tuberculosis.

Walzl G, Haks MC, Joosten SA, Kleynhans L, Ronacher K, Ottenhoff TH.

Cold Spring Harb Perspect Med. 2014 Dec 4;5(4). pii: a018515. doi: 10.1101/cshperspect.a018515. Review.


Host cytokine responses induced after overnight stimulation with novel M. tuberculosis infection phase-dependent antigens show promise as diagnostic candidates for TB disease.

Essone PN, Chegou NN, Loxton AG, Stanley K, Kriel M, van der Spuy G, Franken KL, Ottenhoff TH, Walzl G.

PLoS One. 2014 Jul 15;9(7):e102584. doi: 10.1371/journal.pone.0102584. eCollection 2014.


Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states.

Mihret A, Loxton AG, Bekele Y, Kaufmann SH, Kidd M, Haks MC, Ottenhoff TH, Aseffa A, Howe R, Walzl G.

BMC Infect Dis. 2014 May 13;14:257. doi: 10.1186/1471-2334-14-257.


Differential expression of host biomarkers in saliva and serum samples from individuals with suspected pulmonary tuberculosis.

Phalane KG, Kriel M, Loxton AG, Menezes A, Stanley K, van der Spuy GD, Walzl G, Chegou NN.

Mediators Inflamm. 2013;2013:981984. doi: 10.1155/2013/981984. Epub 2013 Nov 13.


Combination of cytokine responses indicative of latent TB and active TB in Malawian adults.

Hur YG, Gorak-Stolinska P, Ben-Smith A, Lalor MK, Chaguluka S, Dacombe R, Doherty TM, Ottenhoff TH, Dockrell HM, Crampin AC.

PLoS One. 2013 Nov 18;8(11):e79742. doi: 10.1371/journal.pone.0079742. eCollection 2013.


Mycobacterium tuberculosis-specific TNF-α is a potential biomarker for the rapid diagnosis of active tuberculosis disease in Chinese population.

Wang F, Hou H, Xu L, Jane M, Peng J, Lu Y, Zhu Y, Sun Z.

PLoS One. 2013 Nov 11;8(11):e79431. doi: 10.1371/journal.pone.0079431. eCollection 2013.


Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting.

Chegou NN, Detjen AK, Thiart L, Walters E, Mandalakas AM, Hesseling AC, Walzl G.

PLoS One. 2013 May 15;8(5):e64226. doi: 10.1371/journal.pone.0064226. Print 2013.


A simple method to quantitate IP-10 in dried blood and plasma spots.

Aabye MG, Eugen-Olsen J, Werlinrud AM, Holm LL, Tuuminen T, Ravn P, Ruhwald M.

PLoS One. 2012;7(6):e39228. doi: 10.1371/journal.pone.0039228. Epub 2012 Jun 27.


Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.

Chegou NN, Essone PN, Loxton AG, Stanley K, Black GF, van der Spuy GD, van Helden PD, Franken KL, Parida SK, Klein MR, Kaufmann SH, Ottenhoff TH, Walzl G.

PLoS One. 2012;7(6):e38501. doi: 10.1371/journal.pone.0038501. Epub 2012 Jun 5. Erratum in: PLoS One. 2012;7(8). doi:10.1371/annotation/bc36a9c6-d5c0-4d55-bc92-9ce4a07b4f70.


New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.

Geluk A, Bobosha K, van der Ploeg-van Schip JJ, Spencer JS, Banu S, Martins MV, Cho SN, Franken KL, Kim HJ, Bekele Y, Uddin MK, Hadi SA, Aseffa A, Pessolani MC, Pereira GM, Dockrell HM, Ottenhoff TH.

J Immunol. 2012 May 15;188(10):4782-91. doi: 10.4049/jimmunol.1103452. Epub 2012 Apr 13.


Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers.

Aranday-Cortes E, Hogarth PJ, Kaveh DA, Whelan AO, Villarreal-Ramos B, Lalvani A, Vordermeier HM.

PLoS One. 2012;7(2):e30626. doi: 10.1371/journal.pone.0030626. Epub 2012 Feb 16.

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