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Variation in CYP2A6 Activity and Personalized Medicine.

Tanner JA, Tyndale RF.

J Pers Med. 2017 Dec 1;7(4). pii: E18. doi: 10.3390/jpm7040018. Review.


Relationship between UGT1A9 gene polymorphisms, efficacy, and safety of propofol in induced abortions amongst Chinese population: a population-based study.

Wang YB, Zhang RZ, Huang SH, Wang SB, Xie JQ.

Biosci Rep. 2017 Oct 24;37(5). pii: BSR20170722. doi: 10.1042/BSR20170722. Print 2017 Oct 31.


Structure and Protein-Protein Interactions of Human UDP-Glucuronosyltransferases.

Fujiwara R, Yokoi T, Nakajima M.

Front Pharmacol. 2016 Oct 24;7:388. eCollection 2016. Review.


Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.

Kiesel BF, Parise RA, Guo J, Huryn DM, Johnston PA, Colombo R, Sen M, Grandis JR, Beumer JH, Eiseman JL.

Cancer Chemother Pharmacol. 2016 Dec;78(6):1225-1235. Epub 2016 Oct 24.


Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines.

Dluzen DF, Sutliff AK, Chen G, Watson CJ, Ishmael FT, Lazarus P.

J Pharmacol Exp Ther. 2016 Oct;359(1):182-93. doi: 10.1124/jpet.116.235044. Epub 2016 Jul 29.


Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.

Fujiwara R, Maruo Y, Chen S, Tukey RH.

Toxicol Appl Pharmacol. 2015 Nov 15;289(1):124-32. doi: 10.1016/j.taap.2015.08.018. Epub 2015 Sep 2. Review.


Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain.

Sakamoto M, Itoh T, Tukey RH, Fujiwara R.

Drug Metab Pharmacokinet. 2015 Aug;30(4):269-75. doi: 10.1016/j.dmpk.2015.04.004. Epub 2015 May 7.


Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.

Dates CR, Fahmi T, Pyrek SJ, Yao-Borengasser A, Borowa-Mazgaj B, Bratton SM, Kadlubar SA, Mackenzie PI, Haun RS, Radominska-Pandya A.

Cancer Biol Ther. 2015;16(5):714-23. doi: 10.1080/15384047.2015.1026480.


Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain.

Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R.

Drug Metab Dispos. 2015 Jul;43(7):1071-6. doi: 10.1124/dmd.115.063719. Epub 2015 May 7.


Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.

Barrett KG, Fang H, Cukovic D, Dombkowski AA, Kocarek TA, Runge-Morris M.

Drug Metab Dispos. 2015 Jul;43(7):1061-70. doi: 10.1124/dmd.114.061440. Epub 2015 May 6.


Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4.

Jiang L, Liang SC, Wang C, Ge GB, Huo XK, Qi XY, Deng S, Liu KX, Ma XC.

Sci Rep. 2015 Apr 17;5:9627. doi: 10.1038/srep09627.


Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10.

Ramírez J, Mirkov S, House LK, Ratain MJ.

Drug Metab Dispos. 2015 Jul;43(7):928-35. doi: 10.1124/dmd.115.063271. Epub 2015 Apr 13.


Cellular asymmetric catalysis by UDP-glucuronosyltransferase 1A8 shows functional localization to the basolateral plasma membrane.

Ziegler K, Tumova S, Kerimi A, Williamson G.

J Biol Chem. 2015 Mar 20;290(12):7622-33. doi: 10.1074/jbc.M114.634428. Epub 2015 Jan 13.


Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term.

Collier AC, Thévenon AD, Goh W, Hiraoka M, Kendal-Wright CE.

Eur J Drug Metab Pharmacokinet. 2015 Dec;40(4):471-80. doi: 10.1007/s13318-014-0243-4. Epub 2014 Dec 3.


Regioselective glucuronidation of andrographolide and its major derivatives: metabolite identification, isozyme contribution, and species differences.

Tian X, Liang S, Wang C, Wu B, Ge G, Deng S, Liu K, Yang L, Ma X.

AAPS J. 2015 Jan;17(1):156-66. doi: 10.1208/s12248-014-9658-8. Epub 2014 Sep 10. Erratum in: AAPS J. 2015 Mar;17(2):479.


Dietary interactions with the bacterial sensing machinery in the intestine: the plant polyphenol case.

Ahmed Nasef N, Mehta S, Ferguson LR.

Front Genet. 2014 Apr 4;5:64. doi: 10.3389/fgene.2014.00064. eCollection 2014. Review.


UGT2B gene expression analysis in multiple tobacco carcinogen-targeted tissues.

Jones NR, Lazarus P.

Drug Metab Dispos. 2014 Apr;42(4):529-36. doi: 10.1124/dmd.113.054718. Epub 2014 Jan 23.


Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p.

Dluzen DF, Sun D, Salzberg AC, Jones N, Bushey RT, Robertson GP, Lazarus P.

J Pharmacol Exp Ther. 2014 Mar;348(3):465-77. doi: 10.1124/jpet.113.210658. Epub 2014 Jan 7.


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