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Items: 1 to 20 of 26

1.

ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer.

Drosos Y, Escobar D, Chiang MY, Roys K, Valentine V, Valentine MB, Rehg JE, Sahai V, Begley LA, Ye J, Paul L, McKinnon PJ, Sosa-Pineda B.

Sci Rep. 2017 Sep 11;7(1):11144. doi: 10.1038/s41598-017-11661-8.

2.

A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo.

Rogers ZN, McFarland CD, Winters IP, Naranjo S, Chuang CH, Petrov D, Winslow MM.

Nat Methods. 2017 Jul;14(7):737-742. doi: 10.1038/nmeth.4297. Epub 2017 May 22.

3.

Essential Roles of E3 Ubiquitin Ligases in p53 Regulation.

Sane S, Rezvani K.

Int J Mol Sci. 2017 Feb 17;18(2). pii: E442. doi: 10.3390/ijms18020442. Review.

4.

Mechanisms of oncogene-induced genomic instability.

Graziano S, Gonzalo S.

Biophys Chem. 2017 Jun;225:49-57. doi: 10.1016/j.bpc.2016.11.008. Epub 2016 Nov 24. Review.

PMID:
28073589
5.

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.

Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H.

Elife. 2015 Jun 5;4:e06907. doi: 10.7554/eLife.06907.

6.

Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.

Petti E, Jordi F, Buemi V, Dinami R, Benetti R, Blasco MA, Schoeftner S.

Cell Cycle. 2015;14(9):1438-46. doi: 10.1080/15384101.2015.1021517.

7.

Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.

Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA, Donehower LA.

J Pathol. 2014 Apr;232(5):522-33. doi: 10.1002/path.4321. Epub 2014 Jan 29.

8.

The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.

Gupta GP, Vanness K, Barlas A, Manova-Todorova KO, Wen YH, Petrini JH.

Mol Cell. 2013 Nov 7;52(3):353-65. doi: 10.1016/j.molcel.2013.09.001. Epub 2013 Oct 10.

9.

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.

10.

The ATM signaling network in development and disease.

Stracker TH, Roig I, Knobel PA, Marjanović M.

Front Genet. 2013 Mar 25;4:37. doi: 10.3389/fgene.2013.00037. eCollection 2013.

11.

In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.

Pello OM, Chèvre R, Laoui D, De Juan A, Lolo F, Andrés-Manzano MJ, Serrano M, Van Ginderachter JA, Andrés V.

PLoS One. 2012;7(9):e45399. doi: 10.1371/journal.pone.0045399. Epub 2012 Sep 20.

12.

Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.

Parikh N, Shuck RL, Nguyen TA, Herron A, Donehower LA.

Mol Cancer Res. 2012 Jun;10(6):845-55. doi: 10.1158/1541-7786.MCR-12-0089. Epub 2012 Apr 24.

13.

Why are epididymal tumours so rare?

Yeung CH, Wang K, Cooper TG.

Asian J Androl. 2012 May;14(3):465-75. doi: 10.1038/aja.2012.20. Epub 2012 Apr 23. Review.

14.

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.

Barascu A, Le Chalony C, Pennarun G, Genet D, Imam N, Lopez B, Bertrand P.

EMBO J. 2012 Mar 7;31(5):1080-94. doi: 10.1038/emboj.2011.492. Epub 2012 Jan 13.

15.

Molecular damage in cancer: an argument for mTOR-driven aging.

Blagosklonny MV.

Aging (Albany NY). 2011 Dec;3(12):1130-41.

16.

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.

Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-1335. doi: 10.1038/nsmb.2189.

17.

Never-ageing cellular senescence.

Ogrunc M, d'Adda di Fagagna F.

Eur J Cancer. 2011 Jul;47(11):1616-22. doi: 10.1016/j.ejca.2011.04.003. Epub 2011 May 9. Review.

18.

CD248 facilitates tumor growth via its cytoplasmic domain.

Maia M, DeVriese A, Janssens T, Moons M, Lories RJ, Tavernier J, Conway EM.

BMC Cancer. 2011 May 8;11:162. doi: 10.1186/1471-2407-11-162.

19.

The essence of senescence.

Kuilman T, Michaloglou C, Mooi WJ, Peeper DS.

Genes Dev. 2010 Nov 15;24(22):2463-79. doi: 10.1101/gad.1971610. Review.

20.

The ATR barrier to replication-born DNA damage.

López-Contreras AJ, Fernandez-Capetillo O.

DNA Repair (Amst). 2010 Dec 10;9(12):1249-55. doi: 10.1016/j.dnarep.2010.09.012. Epub 2010 Oct 30. Review.

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