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Items: 1 to 20 of 61


Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization.

Schnabolk G, Parsons N, Obert E, Annamalai B, Nasarre C, Tomlinson S, Lewin AS, Rohrer B.

Mol Ther Methods Clin Dev. 2017 Nov 10;9:1-11. doi: 10.1016/j.omtm.2017.11.003. eCollection 2018 Jun 15.


Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins.

Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM.

J Immunol. 2018 Jan 1;200(1):316-326. doi: 10.4049/jimmunol.1602017. Epub 2017 Nov 29.


Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.

Fanelli G, Gonzalez-Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, Naeem A, Garred P, Ali RR, Sacks SH.

Sci Rep. 2017 Nov 7;7(1):14625. doi: 10.1038/s41598-017-15212-z.


Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model.

Rogińska D, Kawa MP, Pius-Sadowska E, Lejkowska R, Łuczkowska K, Wiszniewska B, Kaarniranta K, Paterno JJ, Schmidt CA, Machaliński B, Machalińska A.

Oxid Med Cell Longev. 2017;2017:5306790. doi: 10.1155/2017/5306790. Epub 2017 Aug 8.


Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier.

Zhang YH, Li J, Yang WZ, Xian ZH, Feng QT, Ruan XC.

Int J Ophthalmol. 2017 Jul 18;10(7):1055-1063. doi: 10.18240/ijo.2017.07.06. eCollection 2017.


Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium.

Busch C, Annamalai B, Abdusalamova K, Reichhart N, Huber C, Lin Y, Jo EAH, Zipfel PF, Skerka C, Wildner G, Diedrichs-Möhring M, Rohrer B, Strauß O.

Front Immunol. 2017 Jun 15;8:703. doi: 10.3389/fimmu.2017.00703. eCollection 2017.


Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.

Yang P, Skiba NP, Tewkesbury GM, Treboschi VM, Baciu P, Jaffe GJ.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3073-3085. doi: 10.1167/iovs.16-20083.


The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD.

Datta S, Cano M, Ebrahimi K, Wang L, Handa JT.

Prog Retin Eye Res. 2017 Sep;60:201-218. doi: 10.1016/j.preteyeres.2017.03.002. Epub 2017 Mar 20. Review.


New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement.

Schnabolk G, Beon MK, Tomlinson S, Rohrer B.

J Ocul Pharmacol Ther. 2017 Jun;33(5):400-411. doi: 10.1089/jop.2016.0101. Epub 2017 Mar 23.


Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks.

Ishii M, Rohrer B.

Cell Death Discov. 2017 Feb 6;3:16071. doi: 10.1038/cddiscovery.2016.71. eCollection 2017.


Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology.

Obert E, Strauss R, Brandon C, Grek C, Ghatnekar G, Gourdie R, Rohrer B.

J Mol Med (Berl). 2017 May;95(5):535-552. doi: 10.1007/s00109-017-1506-8. Epub 2017 Jan 28.


Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration.

Song D, Wilson B, Zhao L, Bhuyan R, Bandyopadhyay M, Lyubarsky A, Yu C, Li Y, Kanu L, Miwa T, Song WC, Finnemann SC, Rohrer B, Dunaief JL.

PLoS One. 2016 Nov 28;11(11):e0166348. doi: 10.1371/journal.pone.0166348. eCollection 2016.


Protective responses to sublytic complement in the retinal pigment epithelium.

Tan LX, Toops KA, Lakkaraju A.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8789-94. doi: 10.1073/pnas.1523061113. Epub 2016 Jul 18.


Oxidative stress, innate immunity, and age-related macular degeneration.

Shaw PX, Stiles T, Douglas C, Ho D, Fan W, Du H, Xiao X.

AIMS Mol Sci. 2016;3(2):196-221. Epub 2016 May 11.


A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury.

Woodell A, Jones BW, Williamson T, Schnabolk G, Tomlinson S, Atkinson C, Rohrer B.

Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1728-37. doi: 10.1167/iovs.15-18471.


Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells.

Coughlin B, Schnabolk G, Joseph K, Raikwar H, Kunchithapautham K, Johnson K, Moore K, Wang Y, Rohrer B.

Sci Rep. 2016 Mar 31;6:23794. doi: 10.1038/srep23794.


Inflammation and its role in age-related macular degeneration.

Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K.

Cell Mol Life Sci. 2016 May;73(9):1765-86. doi: 10.1007/s00018-016-2147-8. Epub 2016 Feb 6. Review.


N-Acetylcysteine Amide Protects Against Oxidative Stress-Induced Microparticle Release From Human Retinal Pigment Epithelial Cells.

Carver KA, Yang D.

Invest Ophthalmol Vis Sci. 2016 Feb;57(2):360-71. doi: 10.1167/iovs.15-17117.


Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9.

Georgiannakis A, Burgoyne T, Lueck K, Futter C, Greenwood J, Moss SE.

J Immunol. 2015 Oct 1;195(7):3382-9. doi: 10.4049/jimmunol.1500937. Epub 2015 Aug 31.

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