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Items: 14

1.

Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.

Melnik BC.

J Transl Med. 2015 Dec 21;13:385. doi: 10.1186/s12967-015-0746-z. Review.

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Association of SNP rs9939609 in FTO gene with metabolic syndrome in type 2 diabetic subjects, rectruited from a tertiary care unit of Karachi, Pakistan.

Fawwad A, Siddiqui IA, Zeeshan NF, Shahid SM, Basit A.

Pak J Med Sci. 2015 Jan-Feb;31(1):140-5. doi: 10.12669/pjms.311.6524.

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FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women.

Song DK, Lee H, Oh JY, Hong YS, Sung YA.

Diabetes Metab J. 2014 Aug;38(4):302-10. doi: 10.4093/dmj.2014.38.4.302.

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FTO is a relevant factor for the development of the metabolic syndrome in mice.

Ikels K, Kuschel S, Fischer J, Kaisers W, Eberhard D, Rüther U.

PLoS One. 2014 Aug 21;9(8):e105349. doi: 10.1371/journal.pone.0105349.

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Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low.

Ortega-Azorín C, Sorlí JV, Asensio EM, Coltell O, Martínez-González MÁ, Salas-Salvadó J, Covas MI, Arós F, Lapetra J, Serra-Majem L, Gómez-Gracia E, Fiol M, Sáez-Tormo G, Pintó X, Muñoz MA, Ros E, Ordovás JM, Estruch R, Corella D.

Cardiovasc Diabetol. 2012 Nov 6;11:137. doi: 10.1186/1475-2840-11-137.

8.

FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

Cheung MK, Yeo GS.

Front Endocrinol (Lausanne). 2011 Feb 22;2:4. doi: 10.3389/fendo.2011.00004.

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A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.

Corella D, Arnett DK, Tucker KL, Kabagambe EK, Tsai M, Parnell LD, Lai CQ, Lee YC, Warodomwichit D, Hopkins PN, Ordovas JM.

J Nutr. 2011 Dec;141(12):2219-25. doi: 10.3945/jn.111.143826.

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FTO gene polymorphisms and obesity risk: a meta-analysis.

Peng S, Zhu Y, Xu F, Ren X, Li X, Lai M.

BMC Med. 2011 Jun 8;9:71. doi: 10.1186/1741-7015-9-71.

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An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference.

Rees SD, Islam M, Hydrie MZ, Chaudhary B, Bellary S, Hashmi S, O'Hare JP, Kumar S, Sanghera DK, Chaturvedi N, Barnett AH, Shera AS, Weedon MN, Basit A, Frayling TM, Kelly MA, Jafar TH.

Diabet Med. 2011 Jun;28(6):673-80. doi: 10.1111/j.1464-5491.2011.03257.x.

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Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross.

Derry JM, Zhong H, Molony C, MacNeil D, Guhathakurta D, Zhang B, Mudgett J, Small K, El Fertak L, Guimond A, Selloum M, Zhao W, Champy MF, Monassier L, Vogt T, Cully D, Kasarskis A, Schadt EE.

PLoS One. 2010 Dec 14;5(12):e14319. doi: 10.1371/journal.pone.0014319.

14.

FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.

Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J.

Diabetes. 2011 Jan;60(1):258-68. doi: 10.2337/db10-0281.

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