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Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas.

Presneau N, Duhamel LA, Ye H, Tirabosco R, Flanagan AM, Eskandarpour M.

Br J Cancer. 2017 Jul 25;117(3):398-408. doi: 10.1038/bjc.2017.174. Epub 2017 Jun 20.


Lkb1 deletion in murine B lymphocytes promotes cell death and cancer.

Souroullas GP, Fedoriw Y, Staudt LM, Sharpless NE.

Exp Hematol. 2017 Jul;51:63-70.e1. doi: 10.1016/j.exphem.2017.04.005. Epub 2017 Apr 21.


Coordinated cell motility is regulated by a combination of LKB1 farnesylation and kinase activity.

Wilkinson S, Hou Y, Zoine JT, Saltz J, Zhang C, Chen Z, Cooper LA, Marcus AI.

Sci Rep. 2017 Jan 19;7:40929. doi: 10.1038/srep40929.


Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics.

Lee B, Konen J, Wilkinson S, Marcus AI, Jiang Y.

Sci Rep. 2017 Jan 3;7:39498. doi: 10.1038/srep39498.


LKB1 promotes metabolic flexibility in response to energy stress.

Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM.

Metab Eng. 2016 Dec 26. pii: S1096-7176(16)30282-8. doi: 10.1016/j.ymben.2016.12.010. [Epub ahead of print]


Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.

Schabath MB, Cress D, Munoz-Antonia T.

Cancer Control. 2016 Oct;23(4):338-346.


Somatic Variations in Cervical Cancers in Indian Patients.

Das P, Bansal A, Rao SN, Deodhar K, Mahantshetty U, Shrivastava SK, Sivaraman K, Mulherkar R.

PLoS One. 2016 Nov 9;11(11):e0165878. doi: 10.1371/journal.pone.0165878. eCollection 2016.


LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.

Wang YS, Chen J, Cui F, Wang H, Wang S, Hang W, Zeng Q, Quan CS, Zhai YX, Wang JW, Shen XF, Jian YP, Zhao RX, Werle KD, Cui R, Liang J, Li YL, Xu ZX.

Oncotarget. 2016 Nov 8;7(45):73389-73401. doi: 10.18632/oncotarget.12334.


LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism.

Zeng Q, Chen J, Li Y, Werle KD, Zhao RX, Quan CS, Wang YS, Zhai YX, Wang JW, Youssef M, Cui R, Liang J, Genovese N, Chow LT, Li YL, Xu ZX.

Oncogene. 2017 Mar 2;36(9):1245-1255. doi: 10.1038/onc.2016.290. Epub 2016 Aug 22.


AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.

Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG.

Mol Cancer Res. 2016 Aug;14(8):683-95. doi: 10.1158/1541-7786.MCR-15-0479. Epub 2016 May 2.


The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis.

Xiao J, Zou Y, Chen X, Gao Y, Xie M, Lu X, Li W, He B, He S, You S, Chen Q.

PLoS One. 2016 Apr 1;11(4):e0152674. doi: 10.1371/journal.pone.0152674. eCollection 2016.


Lysosomal recruitment of TSC2 is a universal response to cellular stress.

Demetriades C, Plescher M, Teleman AA.

Nat Commun. 2016 Feb 12;7:10662. doi: 10.1038/ncomms10662.


LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.

Konen J, Wilkinson S, Lee B, Fu H, Zhou W, Jiang Y, Marcus AI.

Mol Biol Cell. 2016 Apr 1;27(7):1069-84. doi: 10.1091/mbc.E15-08-0569. Epub 2016 Feb 10.


Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.

Yung MM, Ngan HY, Chan DW.

Acta Biochim Biophys Sin (Shanghai). 2016 Apr;48(4):301-17. doi: 10.1093/abbs/gmv128. Epub 2016 Jan 12. Review.


Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1.

Rhodes LV, Tate CR, Hoang VT, Burks HE, Gilliam D, Martin EC, Elliott S, Miller DB, Buechlein A, Rusch D, Tang H, Nephew KP, Burow ME, Collins-Burow BM.

Oncogenesis. 2015 Oct 5;4:e168. doi: 10.1038/oncsis.2015.27.


LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.

Peña CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH.

J Clin Invest. 2015 Nov 2;125(11):4063-76. doi: 10.1172/JCI82152. Epub 2015 Sep 28.


Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.

Grossi V, Lucarelli G, Forte G, Peserico A, Matrone A, Germani A, Rutigliano M, Stella A, Bagnulo R, Loconte D, Galleggiante V, Sanguedolce F, Cagiano S, Bufo P, Trabucco S, Maiorano E, Ditonno P, Battaglia M, Resta N, Simone C.

Autophagy. 2015 Nov 2;11(11):2102-2113.


Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system.

Gailite I, Aerne BL, Tapon N.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5169-78. doi: 10.1073/pnas.1505512112. Epub 2015 Aug 31.


LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.

Men Y, Zhang A, Li H, Zhang T, Jin Y, Li H, Zhang J, Gao J.

PLoS One. 2015 Aug 14;10(8):e0135841. doi: 10.1371/journal.pone.0135841. eCollection 2015.


Targeting LKB1 in cancer - exposing and exploiting vulnerabilities.

Momcilovic M, Shackelford DB.

Br J Cancer. 2015 Aug 11;113(4):574-84. doi: 10.1038/bjc.2015.261. Epub 2015 Jul 21. Review.

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