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Items: 16


Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore.

Wray R, Iscla I, Gao Y, Li H, Wang J, Blount P.

PLoS Biol. 2016 Jun 9;14(6):e1002473. doi: 10.1371/journal.pbio.1002473. eCollection 2016 Jun.


Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations.

Iscla I, Wray R, Eaton C, Blount P.

PLoS One. 2015 Sep 14;10(9):e0137994. doi: 10.1371/journal.pone.0137994. eCollection 2015.


Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion.

Li J, Guo J, Ou X, Zhang M, Li Y, Liu Z.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10726-31. doi: 10.1073/pnas.1503202112. Epub 2015 Aug 10.


Electrostatics at the membrane define MscL channel mechanosensitivity and kinetics.

Zhong D, Blount P.

FASEB J. 2014 Dec;28(12):5234-41. doi: 10.1096/fj.14-259309. Epub 2014 Sep 15.


Dynamics of protein-protein interactions at the MscL periplasmic-lipid interface.

Zhong D, Yang LM, Blount P.

Biophys J. 2014 Jan 21;106(2):375-81. doi: 10.1016/j.bpj.2013.12.006.


Improving the Design of a MscL-Based Triggered Nanovalve.

Iscla I, Eaton C, Parker J, Wray R, Kovács Z, Blount P.

Biosensors (Basel). 2013;3(1):171-84. doi: 10.3390/bios3010171.


Structural investigation of MscL gating using experimental data and coarse grained MD simulations.

Deplazes E, Louhivuori M, Jayatilaka D, Marrink SJ, Corry B.

PLoS Comput Biol. 2012;8(9):e1002683. doi: 10.1371/journal.pcbi.1002683. Epub 2012 Sep 20.


The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface.

Iscla I, Wray R, Blount P.

Channels (Austin). 2012 Jul-Aug;6(4):255-61. doi: 10.4161/chan.20756. Epub 2012 Jul 1.


Sensing and responding to membrane tension: the bacterial MscL channel as a model system.

Iscla I, Blount P.

Biophys J. 2012 Jul 18;103(2):169-74. doi: 10.1016/j.bpj.2012.06.021. Epub 2012 Jul 17. Review.


The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves.

Booth IR, Blount P.

J Bacteriol. 2012 Sep;194(18):4802-9. doi: 10.1128/JB.00576-12. Epub 2012 Jun 8. Review.


Three routes to modulate the pore size of the MscL channel/nanovalve.

Yang LM, Wray R, Parker J, Wilson D, Duran RS, Blount P.

ACS Nano. 2012 Feb 28;6(2):1134-41. doi: 10.1021/nn203703j. Epub 2012 Jan 6.


The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo.

Iscla I, Wray R, Blount P.

Protein Sci. 2011 Sep;20(9):1638-42. doi: 10.1002/pro.686. Epub 2011 Jul 19.


S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins.

Dorwart MR, Wray R, Brautigam CA, Jiang Y, Blount P.

PLoS Biol. 2010 Dec 7;8(12):e1000555. doi: 10.1371/journal.pbio.1000555.


An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel.

Iscla I, Wray R, Blount P.

FASEB J. 2011 Feb;25(2):694-702. doi: 10.1096/fj.10-170878. Epub 2010 Nov 10.


An improved open-channel structure of MscL determined from FRET confocal microscopy and simulation.

Corry B, Hurst AC, Pal P, Nomura T, Rigby P, Martinac B.

J Gen Physiol. 2010 Oct;136(4):483-94. doi: 10.1085/jgp.200910376.


Mechanosensitivity of ion channels based on protein-lipid interactions.

Yoshimura K, Sokabe M.

J R Soc Interface. 2010 Jun 6;7 Suppl 3:S307-20. doi: 10.1098/rsif.2010.0095.focus. Epub 2010 Mar 31. Review.

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