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Comorbidity Analysis between Alzheimer's Disease and Type 2 Diabetes Mellitus (T2DM) Based on Shared Pathways and the Role of T2DM Drugs.

Karki R, Kodamullil AT, Hofmann-Apitius M.

J Alzheimers Dis. 2017;60(2):721-731. doi: 10.3233/JAD-170440.


Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity.

Markowicz-Piasecka M, Sikora J, Mateusiak Ł, Mikiciuk-Olasik E, Huttunen KM.

Oxid Med Cell Longev. 2017;2017:7303096. doi: 10.1155/2017/7303096. Epub 2017 Jul 9.


To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents.

Arbeláez-Quintero I, Palacios M.

Stroke Res Treat. 2017;2017:9756429. doi: 10.1155/2017/9756429. Epub 2017 May 28. Review.


Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats.

Chen Q, Mo R, Wu N, Zou X, Shi C, Gong J, Li J, Fang K, Wang D, Yang D, Wang K, Chen J.

Front Pharmacol. 2017 Jun 6;8:334. doi: 10.3389/fphar.2017.00334. eCollection 2017.


Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study.

Koenig AM, Mechanic-Hamilton D, Xie SX, Combs MF, Cappola AR, Xie L, Detre JA, Wolk DA, Arnold SE.

Alzheimer Dis Assoc Disord. 2017 Apr-Jun;31(2):107-113. doi: 10.1097/WAD.0000000000000202.


Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs.

Balbaa M, Abdulmalek SA, Khalil S.

PLoS One. 2017 May 15;12(5):e0172429. doi: 10.1371/journal.pone.0172429. eCollection 2017.


Metformin, Lifestyle Intervention, and Cognition in the Diabetes Prevention Program Outcomes Study.

Luchsinger JA, Ma Y, Christophi CA, Florez H, Golden SH, Hazuda H, Crandall J, Venditti E, Watson K, Jeffries S, Manly JJ, Pi-Sunyer FX; Diabetes Prevention Program Research Group.

Diabetes Care. 2017 Jul;40(7):958-965. doi: 10.2337/dc16-2376. Epub 2017 May 12.


Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels-An Ex Vivo Study.

Śmieszek A, Stręk Z, Kornicka K, Grzesiak J, Weiss C, Marycz K.

Int J Mol Sci. 2017 Apr 20;18(4). pii: E872. doi: 10.3390/ijms18040872.


Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice.

Thangthaeng N, Rutledge M, Wong JM, Vann PH, Forster MJ, Sumien N.

Aging Dis. 2017 Feb 1;8(1):17-30. doi: 10.14336/AD.2016.1010. eCollection 2017 Feb.


Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease.

Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, Hébert SS, Chen JG, Lu Y, Zhu LQ.

Mol Ther. 2017 Mar 1;25(3):752-764. doi: 10.1016/j.ymthe.2017.01.018. Epub 2017 Feb 13.


Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases.

Shpakov AO, Derkach KV, Berstein LM.

Future Sci OA. 2015 Nov 1;1(3):FSO25. doi: 10.4155/fso.15.23. eCollection 2015 Nov. Review.


Medication appropriateness tool for co-morbid health conditions in dementia: consensus recommendations from a multidisciplinary expert panel.

Page AT, Potter K, Clifford R, McLachlan AJ, Etherton-Beer C.

Intern Med J. 2016 Oct;46(10):1189-1197. doi: 10.1111/imj.13215.


Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates.

Picone P, Vilasi S, Librizzi F, Contardi M, Nuzzo D, Caruana L, Baldassano S, Amato A, Mulè F, San Biagio PL, Giacomazza D, Di Carlo M.

Aging (Albany NY). 2016 Aug;8(8):1718-34. doi: 10.18632/aging.101004.


Metformin Alleviated Aβ-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons.

Chen B, Teng Y, Zhang X, Lv X, Yin Y.

Biomed Res Int. 2016;2016:1421430. doi: 10.1155/2016/1421430. Epub 2016 Jun 15.


Impaired fasting glucose is associated with increased regional cerebral amyloid.

Morris JK, Vidoni ED, Wilkins HM, Archer AE, Burns NC, Karcher RT, Graves RS, Swerdlow RH, Thyfault JP, Burns JM.

Neurobiol Aging. 2016 Aug;44:138-142. doi: 10.1016/j.neurobiolaging.2016.04.017. Epub 2016 May 7.


Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders.

Su KH, Dai C.

Cell Mol Life Sci. 2016 Nov;73(22):4231-4248. Epub 2016 Jun 11. Review.


Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease.

Rizvi SM, Shaikh S, Waseem SM, Shakil S, Abuzenadah AM, Biswas D, Tabrez S, Ashraf GM, Kamal MA.

EXCLI J. 2015 May 19;14:684-96. doi: 10.17179/excli2015-252. eCollection 2015. Review.


Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial.

Luchsinger JA, Perez T, Chang H, Mehta P, Steffener J, Pradabhan G, Ichise M, Manly J, Devanand DP, Bagiella E.

J Alzheimers Dis. 2016;51(2):501-14. doi: 10.3233/JAD-150493.


Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy.

Barini E, Antico O, Zhao Y, Asta F, Tucci V, Catelani T, Marotta R, Xu H, Gasparini L.

Mol Neurodegener. 2016 Feb 9;11:16. doi: 10.1186/s13024-016-0082-7.


Recombinant pre-miR-29b for Alzheimer´s disease therapeutics.

Pereira PA, Tomás JF, Queiroz JA, Figueiras AR, Sousa F.

Sci Rep. 2016 Jan 28;6:19946. doi: 10.1038/srep19946.

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