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Items: 1 to 20 of 43


The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.

Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y.

Nat Commun. 2017 Jan 16;8:14002. doi: 10.1038/ncomms14002.


p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis.

Zhang T, Li H, Shi J, Li S, Li M, Zhang L, Zheng L, Zheng D, Tang F, Zhang X, Zhang F, You X.

Arthritis Res Ther. 2016 Nov 24;18(1):271.


IκB kinase b Mediating the Downregulation of p53 and p21 by Lipopolysaccharide in Human Papillomavirus 16+ Cervical Cancer Cells.

Tan ZH, Zhang Y, Tian Y, Tan W, Li YH.

Chin Med J (Engl). 2016 Nov 20;129(22):2703-2707. doi: 10.4103/0366-6999.193463.


The NF-κB Pathway and Cancer Stem Cells.

Rinkenbaugh AL, Baldwin AS.

Cells. 2016 Apr 6;5(2). pii: E16. doi: 10.3390/cells5020016. Review.


Transcriptional Activation of p53 during Cold Induced Torpor in the 13-Lined Ground Squirrel Ictidomys tridecemlineatus.

Hefler J, Wu CW, Storey KB.

Biochem Res Int. 2015;2015:731595. doi: 10.1155/2015/731595. Epub 2015 Dec 30.


Targeting Hsp90 in urothelial carcinoma.

Chehab M, Caza T, Skotnicki K, Landas S, Bratslavsky G, Mollapour M, Bourboulia D.

Oncotarget. 2015 Apr 20;6(11):8454-73. Review.


NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation.

Chen PM, Wu TC, Cheng YW, Chen CY, Lee H.

Oncotarget. 2015 Jun 10;6(16):14274-89.


NF-κB, an active player in human cancers.

Xia Y, Shen S, Verma IM.

Cancer Immunol Res. 2014 Sep;2(9):823-30. doi: 10.1158/2326-6066.CIR-14-0112. Review.


Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism.

Pal S, Bhattacharjee A, Ali A, Mandal NC, Mandal SC, Pal M.

J Inflamm (Lond). 2014 Aug 9;11:23. doi: 10.1186/1476-9255-11-23. eCollection 2014. Review.


Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs.

Ji X, Huang Q, Yu L, Nussinov R, Ma B.

Int J Mol Sci. 2014 Jul 29;15(8):13275-98. doi: 10.3390/ijms150813275.


SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination.

Wu X, Fukushima H, North BJ, Nagaoka Y, Nagashima K, Deng F, Okabe K, Inuzuka H, Wei W.

Oncotarget. 2014 Jun 30;5(12):4211-21.


Caught in the cross fire: p53 in inflammation.

Cooks T, Harris CC, Oren M.

Carcinogenesis. 2014 Aug;35(8):1680-90. doi: 10.1093/carcin/bgu134. Epub 2014 Jun 18. Review.


Induction of Gsk3β-β-TrCP interaction is required for late phase stabilization of β-catenin in canonical Wnt signaling.

Gao C, Chen G, Romero G, Moschos S, Xu X, Hu J.

J Biol Chem. 2014 Mar 7;289(10):7099-108. doi: 10.1074/jbc.M113.532606. Epub 2014 Jan 22.


The IκB kinase complex in NF-κB regulation and beyond.

Hinz M, Scheidereit C.

EMBO Rep. 2014 Jan;15(1):46-61. doi: 10.1002/embr.201337983. Epub 2013 Dec 27. Review.


The hypoxia-inducible transcription factor ZNF395 is controlled by IĸB kinase-signaling and activates genes involved in the innate immune response and cancer.

Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G.

PLoS One. 2013 Sep 23;8(9):e74911. doi: 10.1371/journal.pone.0074911. eCollection 2013.


Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation.

Jiang ZY, Chu HX, Xi MY, Yang TT, Jia JM, Huang JJ, Guo XK, Zhang XJ, You QD, Sun HP.

PLoS One. 2013 Sep 16;8(9):e75076. doi: 10.1371/journal.pone.0075076. eCollection 2013.


A novel mechanism of crosstalk between the p53 and NFκB pathways: MDM2 binds and inhibits p65RelA.

Heyne K, Winter C, Gerten F, Schmidt C, Roemer K.

Cell Cycle. 2013 Aug 1;12(15):2479-92. doi: 10.4161/cc.25495. Epub 2013 Jun 28.


cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation.

Lau R, Niu MY, Pratt MA.

Cell Cycle. 2012 Nov 1;11(21):4009-19. doi: 10.4161/cc.22223. Epub 2012 Oct 3.


Mitotic Kinases and p53 Signaling.

Ha GH, Breuer EK.

Biochem Res Int. 2012;2012:195903. doi: 10.1155/2012/195903. Epub 2012 Jul 19.

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