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Stress-induced adaptive islet cell identity changes.

Cigliola V, Thorel F, Chera S, Herrera PL.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:87-96. doi: 10.1111/dom.12726. Review.


Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy.

Mozar A, Lin H, Williams K, Chin C, Li R, Kondegowda NG, Stewart AF, Garcia-Ocaña A, Vasavada RC.

PLoS One. 2016 Jul 8;11(7):e0158414. doi: 10.1371/journal.pone.0158414.


Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice.

Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF.

JCI Insight. 2016;1(3). pii: e80749.


Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.

Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.

J Biol Chem. 2016 Jun 3;291(23):12029-38. doi: 10.1074/jbc.M116.728170.


Pancreatic Islet Responses to Metabolic Trauma.

Burke SJ, Karlstad MD, Collier JJ.

Shock. 2016 Sep;46(3):230-8. doi: 10.1097/SHK.0000000000000607.


Deletion of β-Arrestin2 in mice limited pancreatic beta-cell expansion under metabolic stress through activation of JNK pathway.

Lin Z, Zhao Y, Song L, Mu K, Zhang M, Liu H, Li X, Zhao J, Wang C, Jia W.

Mol Med. 2016 Feb 29. doi: 10.2119/molmed.2015.00155. [Epub ahead of print]


PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.

Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A.

Diabetes. 2016 May;65(5):1283-96. doi: 10.2337/db15-1398.


FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.

Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH.

Endocrinology. 2016 Mar;157(3):1055-70. doi: 10.1210/en.2015-1852.


Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes.

Assayag-Asherie N, Sever D, Bogdani M, Johnson P, Weiss T, Ginzberg A, Perles S, Weiss L, Sebban LE, Turley EA, Okon E, Raz I, Naor D.

PLoS One. 2015 Dec 1;10(12):e0143589. doi: 10.1371/journal.pone.0143589.


Insulin demand regulates β cell number via the unfolded protein response.

Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC.

J Clin Invest. 2015 Oct 1;125(10):3831-46. doi: 10.1172/JCI79264.


Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.

Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.

PLoS One. 2015 Sep 17;10(9):e0138322. doi: 10.1371/journal.pone.0138322.


Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity.

Merino B, Alonso-Magdalena P, Lluesma M, Ñeco P, Gonzalez A, Marroquí L, García-Arévalo M, Nadal A, Quesada I.

Sci Rep. 2015 Jun 25;5:11622. doi: 10.1038/srep11622.


Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway.

Kondegowda NG, Fenutria R, Pollack IR, Orthofer M, Garcia-Ocaña A, Penninger JM, Vasavada RC.

Cell Metab. 2015 Jul 7;22(1):77-85. doi: 10.1016/j.cmet.2015.05.021.


Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes.

Manna P, Jain SK.

Cell Physiol Biochem. 2015;35(4):1253-75. doi: 10.1159/000373949. Review.


Skeletal muscle insulin resistance in zebrafish induces alterations in β-cell number and glucose tolerance in an age- and diet-dependent manner.

Maddison LA, Joest KE, Kammeyer RM, Chen W.

Am J Physiol Endocrinol Metab. 2015 Apr 15;308(8):E662-9. doi: 10.1152/ajpendo.00441.2014.


Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.

Sun J, Cui J, He Q, Chen Z, Arvan P, Liu M.

Mol Aspects Med. 2015 Apr;42:105-18. doi: 10.1016/j.mam.2015.01.001. Review.


Natural history of β-cell adaptation and failure in type 2 diabetes.

Alejandro EU, Gregg B, Blandino-Rosano M, Cras-Méneur C, Bernal-Mizrachi E.

Mol Aspects Med. 2015 Apr;42:19-41. doi: 10.1016/j.mam.2014.12.002. Review.


Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.

Kim K, Oh CM, Ohara-Imaizumi M, Park S, Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty G, Nagamatsu S, German MS, Kim H.

Endocrinology. 2015 Feb;156(2):444-52. doi: 10.1210/en.2014-1687.


Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/β-cell function in non-diabetic humans.

Galgani JE, Mizgier ML, Mari A, Ravussin E.

Metabolism. 2014 Nov;63(11):1426-31. doi: 10.1016/j.metabol.2014.08.002.


Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice.

García-Arevalo M, Alonso-Magdalena P, Rebelo Dos Santos J, Quesada I, Carneiro EM, Nadal A.

PLoS One. 2014 Jun 24;9(6):e100214. doi: 10.1371/journal.pone.0100214.

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