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Items: 1 to 20 of 45


Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain.

Wu J, Liu Q, Tang P, Mikkelsen JD, Shen J, Whiteaker P, Yakel JL.

Trends Pharmacol Sci. 2016 Jul;37(7):562-74. doi: 10.1016/ Epub 2016 May 11. Review.


Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders.

Kalkman HO, Feuerbach D.

Cell Mol Life Sci. 2016 Jul;73(13):2511-30. doi: 10.1007/s00018-016-2175-4. Epub 2016 Mar 15. Review.


α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells.

Hone AJ, McIntosh JM, Azam L, Lindstrom J, Lucero L, Whiteaker P, Passas J, Blázquez J, Albillos A.

Mol Pharmacol. 2015 Nov;88(5):881-93. doi: 10.1124/mol.115.100982. Epub 2015 Sep 1. Erratum in: Mol Pharmacol. 2016 Feb;89(2):322.


α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation.

Kolisnyk B, Al-Onaizi MA, Prado VF, Prado MA.

Br J Pharmacol. 2015 Oct;172(20):4919-31. doi: 10.1111/bph.13260. Epub 2015 Sep 22.


The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.

Cheng Q, Yakel JL.

Biochem Pharmacol. 2015 Oct 15;97(4):439-44. doi: 10.1016/j.bcp.2015.07.015. Epub 2015 Jul 23. Review.


α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.

Thomsen MS, Zwart R, Ursu D, Jensen MM, Pinborg LH, Gilmour G, Wu J, Sher E, Mikkelsen JD.

PLoS One. 2015 Jun 18;10(6):e0130572. doi: 10.1371/journal.pone.0130572. eCollection 2015.


Cholinergic Mechanisms in the Cerebral Cortex: Beyond Synaptic Transmission.

Ovsepian SV, O'Leary VB, Zaborszky L.

Neuroscientist. 2016 Jun;22(3):238-51. doi: 10.1177/1073858415588264. Epub 2015 May 22.


α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.

Lykhmus O, Voytenko L, Koval L, Mykhalskiy S, Kholin V, Peschana K, Zouridakis M, Tzartos S, Komisarenko S, Skok M.

PLoS One. 2015 Mar 27;10(3):e0122706. doi: 10.1371/journal.pone.0122706. eCollection 2015.


The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.

Sinkus ML, Graw S, Freedman R, Ross RG, Lester HA, Leonard S.

Neuropharmacology. 2015 Sep;96(Pt B):274-88. doi: 10.1016/j.neuropharm.2015.02.006. Epub 2015 Feb 19. Review.


Nicotinic ACh receptors as therapeutic targets in CNS disorders.

Dineley KT, Pandya AA, Yakel JL.

Trends Pharmacol Sci. 2015 Feb;36(2):96-108. doi: 10.1016/ Epub 2015 Jan 29. Review.


Nicotinic and muscarinic agonists and acetylcholinesterase inhibitors stimulate a common pathway to enhance GluN2B-NMDAR responses.

Ishibashi M, Yamazaki Y, Miledi R, Sumikawa K.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12538-43. doi: 10.1073/pnas.1408805111. Epub 2014 Aug 11.


The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization.

Moretti M, Zoli M, George AA, Lukas RJ, Pistillo F, Maskos U, Whiteaker P, Gotti C.

Mol Pharmacol. 2014 Sep;86(3):306-17. doi: 10.1124/mol.114.093377. Epub 2014 Jul 7.


Nicotinic ACh receptors in the hippocampal circuit; functional expression and role in synaptic plasticity.

Yakel JL.

J Physiol. 2014 Oct 1;592(19):4147-53. doi: 10.1113/jphysiol.2014.273896. Epub 2014 May 23. Review.


Insights into distinct modulation of α7 and α7β2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane.

Mowrey DD, Liu Q, Bondarenko V, Chen Q, Seyoum E, Xu Y, Wu J, Tang P.

J Biol Chem. 2013 Dec 13;288(50):35793-800. doi: 10.1074/jbc.M113.508333. Epub 2013 Nov 5.


α7-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability.

Pidoplichko VI, Prager EM, Aroniadou-Anderjaska V, Braga MF.

J Neurophysiol. 2013 Nov;110(10):2358-69. doi: 10.1152/jn.01030.2012. Epub 2013 Sep 4.


Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.

Pandya AA, Yakel JL.

Biochem Pharmacol. 2013 Oct 15;86(8):1054-62. doi: 10.1016/j.bcp.2013.05.018. Epub 2013 May 31. Review.


A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation.

Liu Q, Xie X, Lukas RJ, St John PA, Wu J.

J Neurosci. 2013 Apr 24;33(17):7253-63. doi: 10.1523/JNEUROSCI.3235-12.2013.


Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein.

Liu Q, Emadi S, Shen JX, Sierks MR, Wu J.

PLoS One. 2013;8(2):e55886. doi: 10.1371/journal.pone.0055886. Epub 2013 Feb 20.


Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons.

DuBois DW, Damborsky JC, Fincher AS, Frye GD, Winzer-Serhan UH.

Life Sci. 2013 Mar 14;92(6-7):337-44. doi: 10.1016/j.lfs.2012.12.013. Epub 2013 Jan 24.


Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.

Pandya AA, Yakel JL.

Neuropharmacology. 2013 Jul;70:35-42. doi: 10.1016/j.neuropharm.2013.01.004. Epub 2013 Jan 12.

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