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Items: 17


NSAIDs, Mitochondria and Calcium Signaling: Special Focus on Aspirin/Salicylates.

Suzuki Y, Inoue T, Ra C.

Pharmaceuticals (Basel). 2010 May 19;3(5):1594-1613. Review.


Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice.

Mattheolabakis G, Papayannis I, Yang J, Vaeth BM, Wang R, Bandovic J, Ouyang N, Rigas B, Mackenzie GG.

Cancer Prev Res (Phila). 2016 Jul;9(7):624-34. doi: 10.1158/1940-6207.CAPR-15-0344. Epub 2016 May 2.


Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress.

Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR.

Am J Physiol Cell Physiol. 2015 Dec 1;309(11):C736-46. doi: 10.1152/ajpcell.00050.2015. Epub 2015 Oct 7.


Phospho-aspirin-2 (MDC-22) inhibits estrogen receptor positive breast cancer growth both in vitro and in vivo by a redox-dependent effect.

Huang L, Wong CC, Cheng KW, Rigas B.

PLoS One. 2014 Nov 4;9(11):e111720. doi: 10.1371/journal.pone.0111720. eCollection 2014.


Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress.

Huang L, Wong CC, Mackenzie GG, Sun Y, Cheng KW, Vrankova K, Alston N, Ouyang N, Rigas B.

BMC Cancer. 2014 Feb 28;14:141. doi: 10.1186/1471-2407-14-141.


The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells.

Farrugia G, Balzan R.

Oxid Med Cell Longev. 2013;2013:504230. doi: 10.1155/2013/504230. Epub 2013 Aug 1. Review.


Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice.

Mackenzie GG, Huang L, Alston N, Ouyang N, Vrankova K, Mattheolabakis G, Constantinides PP, Rigas B.

PLoS One. 2013 May 1;8(5):e61532. doi: 10.1371/journal.pone.0061532. Print 2013.


Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical review.

Qandil AM.

Int J Mol Sci. 2012 Dec 17;13(12):17244-74. doi: 10.3390/ijms131217244. Review.


Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity.

Wong CC, Cheng KW, Xie G, Zhou D, Zhu CH, Constantinides PP, Rigas B.

J Pharmacol Exp Ther. 2012 Feb;340(2):422-32. doi: 10.1124/jpet.111.188508. Epub 2011 Nov 15.


Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds.

Huang L, Mackenzie GG, Sun Y, Ouyang N, Xie G, Vrankova K, Komninou D, Rigas B.

Cancer Res. 2011 Dec 15;71(24):7617-27. doi: 10.1158/0008-5472.CAN-11-2349. Epub 2011 Oct 24.


Structure-activity relationship study of novel anticancer aspirin-based compounds.

Joseph S, Nie T, Huang L, Zhou H, Atmakur K, Gupta RC, Johnson F, Rigas B.

Mol Med Rep. 2011 Sep-Oct;4(5):891-9. doi: 10.3892/mmr.2011.534. Epub 2011 Jul 6.


The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats.

Huang L, Mackenzie G, Ouyang N, Sun Y, Xie G, Johnson F, Komninou D, Rigas B.

Br J Pharmacol. 2011 Apr;162(7):1521-33. doi: 10.1111/j.1476-5381.2010.01162.x.


Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.

Huang L, Zhu C, Sun Y, Xie G, Mackenzie GG, Qiao G, Komninou D, Rigas B.

Carcinogenesis. 2010 Nov;31(11):1982-90. doi: 10.1093/carcin/bgq149. Epub 2010 Jul 12.


Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.

Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L, Rigas B.

Gastroenterology. 2010 Oct;139(4):1320-32. doi: 10.1053/j.gastro.2010.06.044. Epub 2010 Jun 20. Erratum in: Gastroenterology. 2012 Mar;142(3):676.


Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo.

Zhang Z, Huang L, Zhao W, Rigas B.

Cancer Res. 2010 Mar 15;70(6):2379-88. doi: 10.1158/0008-5472.CAN-09-4204. Epub 2010 Mar 9.


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