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Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins.

Liu J, Li X, Zhang H, Gu R, Wang Z, Gao Z, Xing L.

Bone Joint Res. 2017 Mar;6(3):154-161. doi: 10.1302/2046-3758.63.BJR-2016-0237.R1.


Molecular basis for specificity of the Met1-linked polyubiquitin signal.

Elliott PR.

Biochem Soc Trans. 2016 Dec 15;44(6):1581-1602. Review.


TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.

Choi YB, Shembade N, Parvatiyar K, Balachandran S, Harhaj EW.

Mol Cell Biol. 2016 Dec 19;37(1). pii: e00422-16. Print 2017 Jan 1.


Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling.

Müller A, Niederstadt L, Jonas W, Yi CX, Meyer F, Wiedmer P, Fischer J, Grötzinger C, Schürmann A, Tschöp M, Kleinau G, Grüters A, Krude H, Biebermann H.

Front Endocrinol (Lausanne). 2016 Aug 8;7:109. doi: 10.3389/fendo.2016.00109. eCollection 2016.


MicroRNA-19b-3p Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF11.

Ashraf U, Zhu B, Ye J, Wan S, Nie Y, Chen Z, Cui M, Wang C, Duan X, Zhang H, Chen H, Cao S.

J Virol. 2016 Apr 14;90(9):4780-95. doi: 10.1128/JVI.02586-15. Print 2016 May.


TNF biology, pathogenic mechanisms and emerging therapeutic strategies.

Kalliolias GD, Ivashkiv LB.

Nat Rev Rheumatol. 2016 Jan;12(1):49-62. doi: 10.1038/nrrheum.2015.169. Epub 2015 Dec 10. Review.


Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis.

Shao B, Wei X, Luo M, Yu J, Tong A, Ma X, Ye T, Deng H, Sang Y, Liang X, Ma Y, Wu Q, Du W, Du J, Gao X, Wen Y, Fu P, Shi H, Luo S, Wei Y.

Sci Rep. 2015 Nov 12;5:16437. doi: 10.1038/srep16437.


Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN.

Elliott PR, Komander D.

FEBS J. 2016 Jan;283(1):39-53. doi: 10.1111/febs.13547. Epub 2015 Nov 2. Review.


Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.

Pujari R, Hunte R, Thomas R, van der Weyden L, Rauch D, Ratner L, Nyborg JK, Ramos JC, Takai Y, Shembade N.

PLoS Pathog. 2015 Mar 16;11(3):e1004721. doi: 10.1371/journal.ppat.1004721. eCollection 2015 Mar.


Mechanisms and pathways of innate immune activation and regulation in health and cancer.

Cui J, Chen Y, Wang HY, Wang RF.

Hum Vaccin Immunother. 2014;10(11):3270-85. doi: 10.4161/21645515.2014.979640. Review.


p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch.

Melino S, Bellomaria A, Nepravishta R, Paci M, Melino G.

Cell Cycle. 2014;13(20):3207-17. doi: 10.4161/15384101.2014.951285.


Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway.

Lavorgna A, Harhaj EW.

Viruses. 2014 Oct 23;6(10):3925-43. doi: 10.3390/v6103925. Review.


HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation.

Choi YB, Harhaj EW.

PLoS Pathog. 2014 Oct 23;10(10):e1004458. doi: 10.1371/journal.ppat.1004458. eCollection 2014 Oct.


The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation.

Rodriguez MS, Egaña I, Lopitz-Otsoa F, Aillet F, Lopez-Mato MP, Dorronsoro A, Lobato-Gil S, Sutherland JD, Barrio R, Trigueros C, Lang V.

Cell Death Dis. 2014 Aug 28;5:e1399. doi: 10.1038/cddis.2014.366. Erratum in: Cell Death Dis. 2014;5:e1520. Dorronroso, A [corrected to Dorronsoro, A].


Expression, purification and crystallization of the SKICH domain of human TAX1BP1.

Yang Y, Wang G, Huang X, Du Z.

Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):619-23. doi: 10.1107/S2053230X14006396. Epub 2014 Apr 15.


Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate.

Yuan S, Dong X, Tao X, Xu L, Ruan J, Peng J, Xu A.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6720-5. doi: 10.1073/pnas.1321187111. Epub 2014 Apr 21.


USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.

Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, Zhang H, An L, Zhao Y, Xu X, Chen Z, Kogiso M, Zhang D, Zhang H, Zhang P, Jung JU, Li X, Xu G, Yang J.

J Exp Med. 2014 Feb 10;211(2):313-28. doi: 10.1084/jem.20122844. Epub 2014 Feb 3.


Protein microarray characterization of the S-nitrosoproteome.

Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Hu J, Ghasemi M, Ischiropoulos H, Qian J, Zhu H, Blackshaw S, Dawson VL, Dawson TM.

Mol Cell Proteomics. 2014 Jan;13(1):63-72. doi: 10.1074/mcp.M113.032235. Epub 2013 Oct 8.


Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.

Zhang H, Wu C, Matesic LE, Li X, Wang Z, Boyce BF, Xing L.

J Biol Chem. 2013 Aug 2;288(31):22359-68. doi: 10.1074/jbc.M112.442459. Epub 2013 Jun 19.

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