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Items: 1 to 20 of 31


The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation.

Brier AB, Loft A, Madsen JGS, Rosengren T, Nielsen R, Schmidt SF, Liu Z, Yan Q, Gronemeyer H, Mandrup S.

Nucleic Acids Res. 2017 Feb 28;45(4):1743-1759. doi: 10.1093/nar/gkw1156.


Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling.

Navarro-Costa P, McCarthy A, Prudêncio P, Greer C, Guilgur LG, Becker JD, Secombe J, Rangan P, Martinho RG.

Nat Commun. 2016 Aug 10;7:12331. doi: 10.1038/ncomms12331.


Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity.

Zhaunova L, Ohkura H, Breuer M.

PLoS Genet. 2016 Aug 5;12(8):e1006241. doi: 10.1371/journal.pgen.1006241. eCollection 2016 Aug.


The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3.

Gajan A, Barnes VL, Liu M, Saha N, Pile LA.

Epigenetics Chromatin. 2016 Feb 3;9:4. doi: 10.1186/s13072-016-0053-9. eCollection 2016.


Homodimeric PHD Domain-containing Rco1 Subunit Constitutes a Critical Interaction Hub within the Rpd3S Histone Deacetylase Complex.

Ruan C, Cui H, Lee CH, Li S, Li B.

J Biol Chem. 2016 Mar 4;291(10):5428-38. doi: 10.1074/jbc.M115.703637. Epub 2016 Jan 8.


The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif.

Liu X, Secombe J.

Cell Rep. 2015 Dec 15;13(10):2219-31. doi: 10.1016/j.celrep.2015.11.007. Epub 2015 Dec 7.


Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer.

Bansal N, Petrie K, Christova R, Chung CY, Leibovitch BA, Howell L, Gil V, Sbirkov Y, Lee E, Wexler J, Ariztia EV, Sharma R, Zhu J, Bernstein E, Zhou MM, Zelent A, Farias E, Waxman S.

Oncotarget. 2015 Oct 27;6(33):34087-105. doi: 10.18632/oncotarget.6048.


KDM5 interacts with Foxo to modulate cellular levels of oxidative stress.

Liu X, Greer C, Secombe J.

PLoS Genet. 2014 Oct 16;10(10):e1004676. doi: 10.1371/journal.pgen.1004676. eCollection 2014 Oct.


Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex.

Nishibuchi G, Shibata Y, Hayakawa T, Hayakawa N, Ohtani Y, Sinmyozu K, Tagami H, Nakayama J.

J Biol Chem. 2014 Oct 17;289(42):28956-70. doi: 10.1074/jbc.M114.573725. Epub 2014 Sep 4.


The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress.

Baker LA, Ueberheide BM, Dewell S, Chait BT, Zheng D, Allis CD.

Mol Cell Biol. 2013 Oct;33(19):3735-48. doi: 10.1128/MCB.00025-13. Epub 2013 Jul 22.


dKDM5/LID regulates H3K4me3 dynamics at the transcription-start site (TSS) of actively transcribed developmental genes.

Lloret-Llinares M, Pérez-Lluch S, Rossell D, Morán T, Ponsa-Cobas J, Auer H, Corominas M, Azorín F.

Nucleic Acids Res. 2012 Oct;40(19):9493-505. doi: 10.1093/nar/gks773. Epub 2012 Aug 16.


Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair.

Joyce EF, Pedersen M, Tiong S, White-Brown SK, Paul A, Campbell SD, McKim KS.

J Cell Biol. 2011 Oct 31;195(3):359-67. doi: 10.1083/jcb.201104121. Epub 2011 Oct 24.


Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

DiTacchio L, Le HD, Vollmers C, Hatori M, Witcher M, Secombe J, Panda S.

Science. 2011 Sep 30;333(6051):1881-5. doi: 10.1126/science.1206022.


Where splicing joins chromatin.

Hnilicová J, Staněk D.

Nucleus. 2011 May-Jun;2(3):182-8. doi: 10.4161/nucl.2.3.15876. Review.


Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.

Chen M, Pereira-Smith OM, Tominaga K.

Stem Cell Res. 2011 Jul;7(1):75-88. doi: 10.1016/j.scr.2011.04.002. Epub 2011 Apr 25.


The complex roles of histone demethylases in vivo.

Di Stefano L, Dyson NJ.

Cell Cycle. 2011 Jul 1;10(13):2049-50. No abstract available.


Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer.

Blair LP, Cao J, Zou MR, Sayegh J, Yan Q.

Cancers (Basel). 2011 Mar 1;3(1):1383-404. doi: 10.3390/cancers3011383.


Suppression of cryptic intragenic transcripts is required for embryonic stem cell self-renewal.

Lin CH, Workman JL.

EMBO J. 2011 Apr 20;30(8):1420-1. doi: 10.1038/emboj.2011.99. No abstract available.


KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription.

Xie L, Pelz C, Wang W, Bashar A, Varlamova O, Shadle S, Impey S.

EMBO J. 2011 Apr 20;30(8):1473-84. doi: 10.1038/emboj.2011.91. Epub 2011 Mar 29.


Selective targeting of histone methylation.

Islam AB, Richter WF, Lopez-Bigas N, Benevolenskaya EV.

Cell Cycle. 2011 Feb 1;10(3):413-24. Epub 2011 Feb 1.

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