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Items: 1 to 20 of 22


Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors.

Byrd KM, Subramanian C, Sanchez J, Motiwala HF, Liu W, Cohen MS, Holzbeierlein J, Blagg BS.

Chemistry. 2016 May 10;22(20):6921-31. doi: 10.1002/chem.201504955. Epub 2016 Apr 1.


HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1.

Wang R, Zhang Y, Kieffer M, Yu H, Kepinski S, Estelle M.

Nat Commun. 2016 Jan 5;7:10269. doi: 10.1038/ncomms10269.


Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?

Khandelwal A, Crowley VM, Blagg BS.

Med Res Rev. 2016 Jan;36(1):92-118. doi: 10.1002/med.21351. Epub 2015 May 25. Review.


The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis.

Brandvold KR, Morimoto RI.

J Mol Biol. 2015 Sep 11;427(18):2931-47. doi: 10.1016/j.jmb.2015.05.010. Epub 2015 May 21. Review.


The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model.

Moses MA, Henry EC, Ricke WA, Gasiewicz TA.

Cancer Prev Res (Phila). 2015 Mar;8(3):249-57. doi: 10.1158/1940-6207.CAPR-14-0224. Epub 2015 Jan 20.


Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors.

Zhao H, Garg G, Zhao J, Moroni E, Girgis A, Franco LS, Singh S, Colombo G, Blagg BS.

Eur J Med Chem. 2015 Jan 7;89:442-66. doi: 10.1016/j.ejmech.2014.10.034. Epub 2014 Oct 14.


Alternative approaches to Hsp90 modulation for the treatment of cancer.

Hall JA, Forsberg LK, Blagg BS.

Future Med Chem. 2014 Sep;6(14):1587-605. doi: 10.4155/fmc.14.89.


High-throughput screen of natural product libraries for hsp90 inhibitors.

Davenport J, Balch M, Galam L, Girgis A, Hall J, Blagg BS, Matts RL.

Biology (Basel). 2014 Feb 10;3(1):101-38. doi: 10.3390/biology3010101.


Molecular cochaperones: tumor growth and cancer treatment.

Calderwood SK.

Scientifica (Cairo). 2013;2013:217513. doi: 10.1155/2013/217513. Epub 2013 Apr 17. Review.


The spectral properties of (-)-epigallocatechin 3-O-gallate (EGCG) fluorescence in different solvents: dependence on solvent polarity.

Snitsarev V, Young MN, Miller RM, Rotella DP.

PLoS One. 2013 Nov 22;8(11):e79834. doi: 10.1371/journal.pone.0079834. eCollection 2013.


Identification of the plant compound geraniin as a novel Hsp90 inhibitor.

Vassallo A, Vaccaro MC, De Tommasi N, Dal Piaz F, Leone A.

PLoS One. 2013 Sep 16;8(9):e74266. doi: 10.1371/journal.pone.0074266. eCollection 2013.


Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells.

Ly BT, Chi HT, Yamagishi M, Kano Y, Hara Y, Nakano K, Sato Y, Watanabe T.

PLoS One. 2013 Jun 20;8(6):e66378. doi: 10.1371/journal.pone.0066378. Print 2013.


Synthesis and structure-activity relationships of EGCG analogues, a recently identified Hsp90 inhibitor.

Khandelwal A, Hall JA, Blagg BS.

J Org Chem. 2013 Aug 16;78(16):7859-84. doi: 10.1021/jo401027r. Epub 2013 Aug 1.


Signal transduction and molecular targets of selected flavonoids.

Bode AM, Dong Z.

Antioxid Redox Signal. 2013 Jul 10;19(2):163-80. doi: 10.1089/ars.2013.5251. Epub 2013 Apr 15. Review.


In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells.

De Amicis F, Russo A, Avena P, Santoro M, Vivacqua A, Bonofiglio D, Mauro L, Aquila S, Tramontano D, Fuqua SA, Andò S.

Mol Nutr Food Res. 2013 May;57(5):840-53. doi: 10.1002/mnfr.201200560. Epub 2013 Jan 16.


Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.

Shim JS, Rao R, Beebe K, Neckers L, Han I, Nahta R, Liu JO.

J Natl Cancer Inst. 2012 Oct 17;104(20):1576-90. doi: 10.1093/jnci/djs396. Epub 2012 Oct 5.


EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes.

Han SG, Han SS, Toborek M, Hennig B.

Toxicol Appl Pharmacol. 2012 Jun 1;261(2):181-8. doi: 10.1016/j.taap.2012.03.024. Epub 2012 Apr 6.


Impact of butyrate on PKM2 and HSP90β expression in human colon tissues of different transformation stages: a comparison of gene and protein data.

Jahns F, Wilhelm A, Greulich KO, Mothes H, Radeva M, Wölfert A, Glei M.

Genes Nutr. 2012 Apr;7(2):235-46. doi: 10.1007/s12263-011-0254-6. Epub 2011 Oct 19.


Gambogic acid, a natural product inhibitor of Hsp90.

Davenport J, Manjarrez JR, Peterson L, Krumm B, Blagg BS, Matts RL.

J Nat Prod. 2011 May 27;74(5):1085-92. doi: 10.1021/np200029q. Epub 2011 Apr 12.


The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells.

Sun X, Huo X, Luo T, Li M, Yin Y, Jiang Y.

J Cell Mol Med. 2011 Nov;15(11):2389-98. doi: 10.1111/j.1582-4934.2010.01244.x.

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