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Items: 20


Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.

Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01711-17. doi: 10.1128/AAC.01711-17. Print 2018 Feb.


Machine learning models identify molecules active against the Ebola virus in vitro.

Ekins S, Freundlich JS, Clark AM, Anantpadma M, Davey RA, Madrid P.

Version 3. F1000Res. 2015 Oct 20 [revised 2017 Jan 1];4:1091. doi: 10.12688/f1000research.7217.3. eCollection 2015.


Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.

Wissing MD, Dadon T, Kim E, Piontek KB, Shim JS, Kaelber NS, Liu JO, Kachhap SK, Nelkin BD.

Oncol Rep. 2014 Jul;32(1):419-24. doi: 10.3892/or.2014.3174. Epub 2014 May 13.


Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.

Aleyasin H, Karuppagounder SS, Kumar A, Sleiman S, Basso M, Ma T, Siddiq A, Chinta SJ, Brochier C, Langley B, Haskew-Layton R, Bane SL, Riggins GJ, Gazaryan I, Starkov AA, Andersen JK, Ratan RR.

Antioxid Redox Signal. 2015 Jan 10;22(2):121-34. doi: 10.1089/ars.2013.5595.


Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia.

Engelhardt S, Patkar S, Ogunshola OO.

Br J Pharmacol. 2014 Mar;171(5):1210-30. doi: 10.1111/bph.12489. Review.


Erythropoietin inhibits HIF-1α expression via upregulation of PHD-2 transcription and translation in an in vitro model of hypoxia-ischemia.

Souvenir R, Flores JJ, Ostrowski RP, Manaenko A, Duris K, Tang J.

Transl Stroke Res. 2014 Feb;5(1):118-27. doi: 10.1007/s12975-013-0312-z. Epub 2013 Nov 27.


Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning.

Brand D, Ratan RR.

Transl Stroke Res. 2013 Feb;4(1):56-62. doi: 10.1007/s12975-012-0235-0. Epub 2013 Jan 8. Review.


Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor.

Gallo-Ebert C, Donigan M, Stroke IL, Swanson RN, Manners MT, Francisco J, Toner G, Gallagher D, Huang CY, Gygax SE, Webb M, Nickels JT Jr.

Antimicrob Agents Chemother. 2014;58(1):258-66. doi: 10.1128/AAC.01677-13. Epub 2013 Oct 21.


High dose deferoxamine in intracerebral hemorrhage (HI-DEF) trial: rationale, design, and methods.

Yeatts SD, Palesch YY, Moy CS, Selim M.

Neurocrit Care. 2013 Oct;19(2):257-66. doi: 10.1007/s12028-013-9861-y.


Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.

Speer RE, Karuppagounder SS, Basso M, Sleiman SF, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR.

Free Radic Biol Med. 2013 Sep;62:26-36. doi: 10.1016/j.freeradbiomed.2013.01.026. Epub 2013 Jan 31. Review.


Radiation damage and radioprotectants: new concepts in the era of molecular medicine.

Koukourakis MI.

Br J Radiol. 2012 Apr;85(1012):313-30. doi: 10.1259/bjr/16386034. Epub 2012 Jan 31.


Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage.

Selim M, Yeatts S, Goldstein JN, Gomes J, Greenberg S, Morgenstern LB, Schlaug G, Torbey M, Waldman B, Xi G, Palesch Y; Deferoxamine Mesylate in Intracerebral Hemorrhage Investigators.

Stroke. 2011 Nov;42(11):3067-74. doi: 10.1161/STROKEAHA.111.617589. Epub 2011 Aug 25.


Pharmacologic preconditioning: translating the promise.

Gidday JM.

Transl Stroke Res. 2010 Jan 3;1(1):19-30. doi: 10.1007/s12975-010-0011-y.


The role of the blood transcriptome in innate inflammation and stroke.

Freedman JE, Vitseva O, Tanriverdi K.

Ann N Y Acad Sci. 2010 Oct;1207:41-5. doi: 10.1111/j.1749-6632.2010.05731.x. Review.


Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.

Morgenstern LB, Hemphill JC 3rd, Anderson C, Becker K, Broderick JP, Connolly ES Jr, Greenberg SM, Huang JN, MacDonald RL, Messé SR, Mitchell PH, Selim M, Tamargo RJ; American Heart Association Stroke Council and Council on Cardiovascular Nursing.

Stroke. 2010 Sep;41(9):2108-29. doi: 10.1161/STR.0b013e3181ec611b. Epub 2010 Jul 22.


Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds.

Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6976-81. doi: 10.1073/pnas.1001653107. Epub 2010 Mar 22.


HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease.

Niatsetskaya Z, Basso M, Speer RE, McConoughey SJ, Coppola G, Ma TC, Ratan RR.

Antioxid Redox Signal. 2010 Apr;12(4):435-43. doi: 10.1089/ars.2009.2800.


Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.

Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR.

J Neurosci. 2009 Jul 8;29(27):8828-38. doi: 10.1523/JNEUROSCI.1779-09.2009.


Novel multi-modal strategies to promote brain and spinal cord injury recovery.

Ratan RR, Noble M.

Stroke. 2009 Mar;40(3 Suppl):S130-2. doi: 10.1161/STROKEAHA.108.534933. Epub 2008 Dec 8.

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