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Involvement of Brd4 in different steps of the papillomavirus life cycle.

Iftner T, Haedicke-Jarboui J, Wu SY, Chiang CM.

Virus Res. 2017 Mar 2;231:76-82. doi: 10.1016/j.virusres.2016.12.006. Epub 2016 Dec 10. Review.


Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions.

Culleton SP, Kanginakudru S, DeSmet M, Gilson T, Xie F, Wu SY, Chiang CM, Qi G, Wang M, Androphy EJ.

J Virol. 2017 Jan 3;91(2). pii: e01854-16. doi: 10.1128/JVI.01854-16. Print 2017 Jan 15.


Phospho-BRD4: transcription plasticity and drug targeting.

Chiang CM.

Drug Discov Today Technol. 2016 Mar;19:17-22. doi: 10.1016/j.ddtec.2016.05.003. Epub 2016 Jul 18. Review.


BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression.

Wu SY, Nin DS, Lee AY, Simanski S, Kodadek T, Chiang CM.

Cell Rep. 2016 Aug 9;16(6):1733-48. doi: 10.1016/j.celrep.2016.07.001. Epub 2016 Jul 28.


Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.

Delcuratolo M, Fertey J, Schneider M, Schuetz J, Leiprecht N, Hudjetz B, Brodbeck S, Corall S, Dreer M, Schwab RM, Grimm M, Wu SY, Stubenrauch F, Chiang CM, Iftner T.

PLoS Pathog. 2016 Jan 4;12(1):e1005366. doi: 10.1371/journal.ppat.1005366. eCollection 2016 Jan 4.


Regulation of mammalian transcription and splicing by Nuclear RNAi.

Kalantari R, Chiang CM, Corey DR.

Nucleic Acids Res. 2016 Jan 29;44(2):524-37. doi: 10.1093/nar/gkv1305. Epub 2015 Nov 26. Review.


Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement.

Gauson EJ, Wang X, Dornan ES, Herzyk P, Bristol M, Morgan IM.

Virus Res. 2016 Jan 4;211:1-8. doi: 10.1016/j.virusres.2015.09.008. Epub 2015 Sep 10.


Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication.

Gauson EJ, Donaldson MM, Dornan ES, Wang X, Bristol M, Bodily JM, Morgan IM.

J Virol. 2015 May;89(9):4980-91. doi: 10.1128/JVI.00335-15. Epub 2015 Feb 18.


Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes.

Chang SW, Liu WC, Liao KY, Tsao YP, Hsu PH, Chen SL.

PLoS One. 2014 Oct 23;9(10):e110882. doi: 10.1371/journal.pone.0110882. eCollection 2014 Oct 23.


The role of ubiquitin and ubiquitin-like modification systems in papillomavirus biology.

Wilson VG.

Viruses. 2014 Sep 24;6(9):3584-611. doi: 10.3390/v6093584. Review.


Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.

Itzen F, Greifenberg AK, Bösken CA, Geyer M.

Nucleic Acids Res. 2014 Jul;42(12):7577-90. doi: 10.1093/nar/gku449. Epub 2014 May 23.


Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis.

Ray S, Zhao Y, Jamaluddin M, Edeh CB, Lee C, Brasier AR.

Cell Signal. 2014 Jul;26(7):1445-55. doi: 10.1016/j.cellsig.2014.03.007. Epub 2014 Mar 20.


Brd4-mediated nuclear retention of the papillomavirus E2 protein contributes to its stabilization in host cells.

Li J, Li Q, Diaz J, You J.

Viruses. 2014 Jan 20;6(1):319-35. doi: 10.3390/v6010319.


Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA.

Sakakibara N, Chen D, Jang MK, Kang DW, Luecke HF, Wu SY, Chiang CM, McBride AA.

PLoS Pathog. 2013;9(11):e1003777. doi: 10.1371/journal.ppat.1003777. Epub 2013 Nov 21.


A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

Hellert J, Weidner-Glunde M, Krausze J, Richter U, Adler H, Fedorov R, Pietrek M, Rückert J, Ritter C, Schulz TF, Lührs T.

PLoS Pathog. 2013;9(10):e1003640. doi: 10.1371/journal.ppat.1003640. Epub 2013 Oct 17.


BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.

Da Costa D, Agathanggelou A, Perry T, Weston V, Petermann E, Zlatanou A, Oldreive C, Wei W, Stewart G, Longman J, Smith E, Kearns P, Knapp S, Stankovic T.

Blood Cancer J. 2013 Jul 19;3:e126. doi: 10.1038/bcj.2013.24.


The papillomavirus E2 proteins.

McBride AA.

Virology. 2013 Oct;445(1-2):57-79. doi: 10.1016/j.virol.2013.06.006. Epub 2013 Jul 10. Review.


Current understanding of the role of the Brd4 protein in the papillomavirus lifecycle.

McBride AA, Jang MK.

Viruses. 2013 May 30;5(6):1374-94. doi: 10.3390/v5061374. Review.


Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA.

Zou Z, Huang B, Wu X, Zhang H, Qi J, Bradner J, Nair S, Chen LF.

Oncogene. 2014 May 1;33(18):2395-404. doi: 10.1038/onc.2013.179. Epub 2013 May 20.

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