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Items: 1 to 20 of 51


Design, preparation, and selection of DNA-encoded dynamic libraries.

Li G, Zheng W, Chen Z, Zhou Y, Liu Y, Yang J, Huang Y, Li X.

Chem Sci. 2015 Dec 1;6(12):7097-7104. doi: 10.1039/c5sc02467f. Epub 2015 Sep 11.


HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.

Hilimire TA, Chamberlain JM, Anokhina V, Bennett RP, Swart O, Myers JR, Ashton JM, Stewart RA, Featherston AL, Gates K, Helms ED, Smith HC, Dewhurst S, Miller BL.

ACS Chem Biol. 2017 Jun 16;12(6):1674-1682. doi: 10.1021/acschembio.7b00052. Epub 2017 May 5.


Antiparallel Dynamic Covalent Chemistries.

Matysiak BM, Nowak P, Cvrtila I, Pappas CG, Liu B, Komáromy D, Otto S.

J Am Chem Soc. 2017 May 17;139(19):6744-6751. doi: 10.1021/jacs.7b02575. Epub 2017 May 9.


Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases.

Koon AC, Chan HY.

Front Cell Neurosci. 2017 Mar 21;11:70. doi: 10.3389/fncel.2017.00070. eCollection 2017. Review.


Myotonic dystrophy: approach to therapy.

Thornton CA, Wang E, Carrell EM.

Curr Opin Genet Dev. 2017 Jun;44:135-140. doi: 10.1016/j.gde.2017.03.007. Epub 2017 Apr 1. Review.


The Emerging Role of RNA as a Therapeutic Target for Small Molecules.

Connelly CM, Moon MH, Schneekloth JS Jr.

Cell Chem Biol. 2016 Sep 22;23(9):1077-1090. doi: 10.1016/j.chembiol.2016.05.021. Epub 2016 Sep 1. Review.


Cyclic mismatch binding ligand CMBL4 binds to the 5'-T-3'/5'-GG-3' site by inducing the flipping out of thymine base.

Mukherjee S, Dohno C, Asano K, Nakatani K.

Nucleic Acids Res. 2016 Sep 6;44(15):7090-9. doi: 10.1093/nar/gkw672. Epub 2016 Jul 27.


Identification of Plant-derived Alkaloids with Therapeutic Potential for Myotonic Dystrophy Type I.

Herrendorff R, Faleschini MT, Stiefvater A, Erne B, Wiktorowicz T, Kern F, Hamburger M, Potterat O, Kinter J, Sinnreich M.

J Biol Chem. 2016 Aug 12;291(33):17165-77. doi: 10.1074/jbc.M115.710616. Epub 2016 Jun 13.


An Evolved RNA Recognition Motif That Suppresses HIV-1 Tat/TAR-Dependent Transcription.

Crawford DW, Blakeley BD, Chen PH, Sherpa C, Le Grice SF, Laird-Offringa IA, McNaughton BR.

ACS Chem Biol. 2016 Aug 19;11(8):2206-15. doi: 10.1021/acschembio.6b00145. Epub 2016 Jun 13.


A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.

Luu LM, Nguyen L, Peng S, Lee J, Lee HY, Wong CH, Hergenrother PJ, Chan HY, Zimmerman SC.

ChemMedChem. 2016 Jul 5;11(13):1428-35. doi: 10.1002/cmdc.201600081. Epub 2016 Jun 1.


Probing the geometric constraints of RNA binding via dynamic covalent chemistry.

McAnany JD, Reichert JP, Miller BL.

Bioorg Med Chem. 2016 Sep 1;24(17):3940-3946. doi: 10.1016/j.bmc.2016.02.029. Epub 2016 Feb 24.


Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy.

Nakamori M, Taylor K, Mochizuki H, Sobczak K, Takahashi MP.

Ann Clin Transl Neurol. 2015 Dec 10;3(1):42-54. doi: 10.1002/acn3.271. eCollection 2016 Jan.


Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Childs-Disney JL, Disney MD.

Annu Rev Pharmacol Toxicol. 2016;56:123-40. doi: 10.1146/annurev-pharmtox-010715-103910. Epub 2015 Oct 22. Review.


Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1.

Yildirim I, Chakraborty D, Disney MD, Wales DJ, Schatz GC.

J Chem Theory Comput. 2015 Oct 13;11(10):4943-58. doi: 10.1021/acs.jctc.5b00728.


A dynamic combinatorial approach for identifying side groups that stabilize DNA-templated supramolecular self-assemblies.

Paolantoni D, Cantel S, Dumy P, Ulrich S.

Int J Mol Sci. 2015 Feb 6;16(2):3609-25. doi: 10.3390/ijms16023609.


Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?

Donnelly CJ, Grima JC, Sattler R.

Neurodegener Dis Manag. 2014;4(6):417-37. doi: 10.2217/nmt.14.36.


MBNL proteins and their target RNAs, interaction and splicing regulation.

Konieczny P, Stepniak-Konieczna E, Sobczak K.

Nucleic Acids Res. 2014;42(17):10873-87. doi: 10.1093/nar/gku767. Epub 2014 Sep 2. Review.


Small molecules that target the toxic RNA in myotonic dystrophy type 2.

Nguyen L, Lee J, Wong CH, Zimmerman SC.

ChemMedChem. 2014 Nov;9(11):2455-62. doi: 10.1002/cmdc.201402095. Epub 2014 Jun 17.


Alternative methods of processing bio-feedstocks in formulated consumer product design.

Peremezhney N, Jacob PM, Lapkin A.

Front Chem. 2014 May 13;2:26. doi: 10.3389/fchem.2014.00026. eCollection 2014.

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