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Items: 1 to 20 of 88


Untangling Genetic Risk for Alzheimer's Disease.

Pimenova AA, Raj T, Goate AM.

Biol Psychiatry. 2017 May 22. pii: S0006-3223(17)31587-1. doi: 10.1016/j.biopsych.2017.05.014. [Epub ahead of print] Review.


Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity.

Neustadtl AL, Winston CN, Parsadanian M, Main BS, Villapol S, Burns MP.

Neuroreport. 2017 Jul 5;28(10):618-624. doi: 10.1097/WNR.0000000000000811.


Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease.

Zhao N, Liu CC, Qiao W, Bu G.

Biol Psychiatry. 2017 Mar 14. pii: S0006-3223(17)31358-6. doi: 10.1016/j.biopsych.2017.03.003. [Epub ahead of print] Review.


EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.

Tai LM, Balu D, Avila-Munoz E, Abdullah L, Thomas R, Collins N, Valencia-Olvera AC, LaDu MJ.

J Lipid Res. 2017 Sep;58(9):1733-1755. doi: 10.1194/jlr.R076315. Epub 2017 Apr 7.


The role of APOE on lipid homeostasis and inflammation in normal brains.

Rebeck GW.

J Lipid Res. 2017 Aug;58(8):1493-1499. doi: 10.1194/jlr.R075408. Epub 2017 Mar 2. Review.


Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism.

Nielsen HM, Chen K, Lee W, Chen Y, Bauer RJ 3rd, Reiman E, Caselli R, Bu G.

Alzheimers Res Ther. 2017 Jan 30;9(1):5. doi: 10.1186/s13195-016-0231-9.


Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.

Mol Neurodegener. 2016 Dec 8;11(1):74. Erratum in: Mol Neurodegener. 2017 Jan 12;12 (1):3.


Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins.

Boehm-Cagan A, Bar R, Harats D, Shaish A, Levkovitz H, Bielicki JK, Johansson JO, Michaelson DM.

PLoS One. 2016 Nov 8;11(11):e0166195. doi: 10.1371/journal.pone.0166195. eCollection 2016.


Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma.

Baker-Nigh AT, Mawuenyega KG, Bollinger JG, Ovod V, Kasten T, Franklin EE, Liao F, Jiang H, Holtzman D, Cairns NJ, Morris JC, Bateman RJ.

J Biol Chem. 2016 Dec 30;291(53):27204-27218. doi: 10.1074/jbc.M116.721779. Epub 2016 Oct 28.


Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors.

Uchoa MF, Moser VA, Pike CJ.

Front Neuroendocrinol. 2016 Oct;43:60-82. doi: 10.1016/j.yfrne.2016.09.001. Epub 2016 Sep 17. Review.


Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes.

Fan J, Zareyan S, Zhao W, Shimizu Y, Pfeifer TA, Tak JH, Isman MB, Van den Hoven B, Duggan ME, Wood MW, Wellington CL, Kulic I.

PLoS One. 2016 Sep 6;11(9):e0162384. doi: 10.1371/journal.pone.0162384. eCollection 2016.


APOE genotype and stress response - a mini review.

Dose J, Huebbe P, Nebel A, Rimbach G.

Lipids Health Dis. 2016 Jul 25;15:121. doi: 10.1186/s12944-016-0288-2. Review.


Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.

Mahley RW.

J Mol Med (Berl). 2016 Jul;94(7):739-46. doi: 10.1007/s00109-016-1427-y. Epub 2016 Jun 9. Review.


ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model.

Chan ES, Shetty MS, Sajikumar S, Chen C, Soong TW, Wong BS.

Sci Rep. 2016 May 18;6:26119. doi: 10.1038/srep26119.


Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.

Mahley RW.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1305-15. doi: 10.1161/ATVBAHA.116.307023. Epub 2016 May 12. Review.


Identification and modification of amyloid-independent phenotypes of APOE4 mice.

DiBattista AM, Dumanis SB, Newman J, Rebeck GW.

Exp Neurol. 2016 Jun;280:97-105. doi: 10.1016/j.expneurol.2016.04.014. Epub 2016 Apr 14.


Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.

Lazaris A, Hwang KS, Goukasian N, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin AJ, Shaw LM, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG; Alzheimer's Disease Neuroimaging Initiative.

Neurol Genet. 2015 Oct 15;1(3):e22. doi: 10.1212/NXG.0000000000000022. eCollection 2015 Oct.


APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations.

Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G.

Ann Neurol. 2016 Mar 2. doi: 10.1002/ana.24628. [Epub ahead of print]


Genetic variants associated with neurodegenerative Alzheimer disease in natural models.

Salazar C, Valdivia G, Ardiles ÁO, Ewer J, Palacios AG.

Biol Res. 2016 Feb 26;49:14. doi: 10.1186/s40659-016-0072-9. Review.


High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.

Lane-Donovan C, Herz J.

PLoS One. 2016 Feb 1;11(2):e0148099. doi: 10.1371/journal.pone.0148099. eCollection 2016.

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