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Items: 1 to 20 of 41


Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.

Prodjinotho UF, von Horn C, Debrah AY, Batsa Debrah L, Albers A, Layland LE, Hoerauf A, Adjobimey T.

PLoS Negl Trop Dis. 2017 Jul 24;11(7):e0005777. doi: 10.1371/journal.pntd.0005777. eCollection 2017 Jul.


A new methodology for sampling blackflies for the entomological surveillance of onchocerciasis in Brazil.

Nascimento-Carvalho ÉSD, Cesário RA, do Vale VF, Aranda AT, Valente ACDS, Maia-Herzog M.

PLoS One. 2017 Jul 20;12(7):e0179754. doi: 10.1371/journal.pone.0179754. eCollection 2017.


Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial.

Klarmann-Schulz U, Specht S, Debrah AY, Batsa L, Ayisi-Boateng NK, Osei-Mensah J, Mubarik Y, Konadu P, Ricchiuto A, Fimmers R, Arriens S, Dubben B, Ford L, Taylor M, Hoerauf A.

PLoS Negl Trop Dis. 2017 Jan 5;11(1):e0005156. doi: 10.1371/journal.pntd.0005156. eCollection 2017 Jan.


rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines.

Chukwudi CU.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4433-41. doi: 10.1128/AAC.00594-16. Print 2016 Aug. Review.


Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.

Binnebose AM, Haughney SL, Martin R, Imerman PM, Narasimhan B, Bellaire BH.

PLoS Negl Trop Dis. 2015 Oct 23;9(10):e0004173. doi: 10.1371/journal.pntd.0004173. eCollection 2015.


Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals.

Arndts K, Klarmann-Schulz U, Batsa L, Debrah AY, Epp C, Fimmers R, Specht S, Layland LE, Hoerauf A.

Parasit Vectors. 2015 Mar 28;8:184. doi: 10.1186/s13071-015-0786-5.


Comparative analysis of wolbachia genomes reveals streamlining and divergence of minimalist two-component systems.

Christensen S, Serbus LR.

G3 (Bethesda). 2015 Mar 24;5(5):983-96. doi: 10.1534/g3.115.017137.


A randomized controlled trial of increased dose and frequency of albendazole with standard dose DEC for treatment of Wuchereria bancrofti microfilaremics in Odisha, India.

Kar SK, Dwibedi B, Kerketa AS, Maharana A, Panda SS, Mohanty PC, Horton J, Ramachandran CP.

PLoS Negl Trop Dis. 2015 Mar 17;9(3):e0003583. doi: 10.1371/journal.pntd.0003583. eCollection 2015 Mar.


Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness.

Walker M, Specht S, Churcher TS, Hoerauf A, Taylor MJ, Basáñez MG.

Clin Infect Dis. 2015 Apr 15;60(8):1199-207. doi: 10.1093/cid/ciu1152. Epub 2014 Dec 23.


Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis.

Johnston KL, Ford L, Umareddy I, Townson S, Specht S, Pfarr K, Hoerauf A, Altmeyer R, Taylor MJ.

Int J Parasitol Drugs Drug Resist. 2014 Sep 16;4(3):278-86. doi: 10.1016/j.ijpddr.2014.09.001. eCollection 2014 Dec.


Wolbachia endosymbiont of Brugia malayi elicits a T helper type 17-mediated pro-inflammatory immune response through Wolbachia surface protein.

Pathak M, Verma M, Srivastava M, Misra-Bhattacharya S.

Immunology. 2015 Feb;144(2):231-44. doi: 10.1111/imm.12364.


Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L.

Metuge JA, Nyongbela KD, Mbah JA, Samje M, Fotso G, Babiaka SB, Cho-Ngwa F.

BMC Complement Altern Med. 2014 Jul 7;14:223. doi: 10.1186/1472-6882-14-223.


Wolbachia transcription elongation factor "Wol GreA" interacts with α2ββ'σ subunits of RNA polymerase through its dimeric C-terminal domain.

Nag JK, Shrivastava N, Chahar D, Gupta CL, Bajpai P, Misra-Bhattacharya S.

PLoS Negl Trop Dis. 2014 Jun 19;8(6):e2930. doi: 10.1371/journal.pntd.0002930. eCollection 2014 Jun.


Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.

Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A.

PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2679. doi: 10.1371/journal.pntd.0002679. eCollection 2014 Feb.


Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis.

Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA.

Parasitology. 2014 Jan;141(1):119-27. doi: 10.1017/S0031182013001108. Epub 2013 Jul 18. Review.


A potential role for the interaction of Wolbachia surface proteins with the Brugia malayi glycolytic enzymes and cytoskeleton in maintenance of endosymbiosis.

Melnikow E, Xu S, Liu J, Bell AJ, Ghedin E, Unnasch TR, Lustigman S.

PLoS Negl Trop Dis. 2013 Apr 4;7(4):e2151. doi: 10.1371/journal.pntd.0002151. Print 2013.


Neglected tropical diseases: survey and geometry of randomised evidence.

Kappagoda S, Ioannidis JP.

BMJ. 2012 Oct 22;345:e6512. doi: 10.1136/bmj.e6512. Review.


Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis.

Darby AC, Armstrong SD, Bah GS, Kaur G, Hughes MA, Kay SM, Koldkjær P, Rainbow L, Radford AD, Blaxter ML, Tanya VN, Trees AJ, Cordaux R, Wastling JM, Makepeace BL.

Genome Res. 2012 Dec;22(12):2467-77. doi: 10.1101/gr.138420.112. Epub 2012 Aug 23.


Alternative activation of macrophages by filarial nematodes is MyD88-independent.

Mylonas KJ, Hoeve MA, MacDonald AS, Allen JE.

Immunobiology. 2013 Apr;218(4):570-8. doi: 10.1016/j.imbio.2012.07.006. Epub 2012 Jul 21.

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