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Mechanism of microtubule stabilization by taccalonolide AJ.

Wang Y, Yu Y, Li GB, Li SA, Wu C, Gigant B, Qin W, Chen H, Wu Y, Chen Q, Yang J.

Nat Commun. 2017 Jun 6;8:15787. doi: 10.1038/ncomms15787.


Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.

Field JJ, Northcote PT, Paterson I, Altmann KH, Díaz JF, Miller JH.

Int J Mol Sci. 2017 May 3;18(5). pii: E971. doi: 10.3390/ijms18050971.


Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.

Gupton JT, Yeudall S, Telang N, Hoerrner M, Huff E, Crawford E, Lounsbury K, Kimmel M, Curry W, Harrison A, Juekun W, Shimozono A, Ortolani J, Lescalleet K, Patteson J, Moore-Stoll V, Rohena CC, Mooberry SL, Obaidullah AJ, Kellogg GE, Sikorski JA.

Bioorg Med Chem. 2017 Jun 15;25(12):3206-3214. doi: 10.1016/j.bmc.2017.04.012. Epub 2017 Apr 11.


Polymer conjugate of a microtubule destabilizer inhibits lung metastatic melanoma.

Yang R, Mondal G, Ness RA, Arnst K, Mundra V, Miller DD, Li W, Mahato RI.

J Control Release. 2017 Mar 10;249:32-41. doi: 10.1016/j.jconrel.2017.01.028. Epub 2017 Jan 24.


Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.

Rohena CC, Risinger AL, Devambatla RK, Dybdal-Hargreaves NF, Kaul R, Choudhary S, Gangjee A, Mooberry SL.

Molecules. 2016 Dec 2;21(12). pii: E1661.


Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.

Rohena CC, Telang NS, Da C, Risinger AL, Sikorski JA, Kellogg GE, Gupton JT, Mooberry SL.

Mol Pharmacol. 2016 Feb;89(2):287-96. doi: 10.1124/mol.115.101592. Epub 2015 Dec 11. Erratum in: Mol Pharmacol. 2016 Sep;90(3):411-2.


Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica.

Youssef DT, Shaala LA, Alshali KZ.

Mar Drugs. 2015 Oct 28;13(11):6609-19. doi: 10.3390/md13116609.


The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.

Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A.

Bioorg Med Chem. 2015 May 15;23(10):2408-23. doi: 10.1016/j.bmc.2015.03.061. Epub 2015 Mar 30.


Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate.

Shaala LA, Youssef DT.

Mar Drugs. 2015 Mar 25;13(4):1698-709. doi: 10.3390/md13041698.


Bioactive secondary metabolites from the Red Sea marine Verongid sponge Suberea species.

Shaala LA, Youssef DT, Badr JM, Sulaiman M, Khedr A.

Mar Drugs. 2015 Mar 24;13(4):1621-31. doi: 10.3390/md13041621.


P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review.

Abdallah HM, Al-Abd AM, El-Dine RS, El-Halawany AM.

J Adv Res. 2015 Jan;6(1):45-62. doi: 10.1016/j.jare.2014.11.008. Epub 2014 Dec 1. Review.


Didemnaketals f and g, new bioactive spiroketals from a red sea ascidian didemnum species.

Shaala LA, Youssef DT, Ibrahim SR, Mohamed GA, Badr JM, Risinger AL, Mooberry SL.

Mar Drugs. 2014 Sep 25;12(9):5021-34. doi: 10.3390/md12095021.


Synthetic reactions with rare taccalonolides reveal the value of C-22,23 epoxidation for microtubule stabilizing potency.

Peng J, Risinger AL, Li J, Mooberry SL.

J Med Chem. 2014 Jul 24;57(14):6141-9. doi: 10.1021/jm500619j. Epub 2014 Jul 2.


Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum.

Du L, Robles AJ, King JB, Mooberry SL, Cichewicz RH.

J Nat Prod. 2014 Jun 27;77(6):1459-66. doi: 10.1021/np5002253. Epub 2014 Jun 3.


The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.

Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A.

Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14.


The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation.

Risinger AL, Riffle SM, Lopus M, Jordan MA, Wilson L, Mooberry SL.

Mol Cancer. 2014 Feb 28;13:41. doi: 10.1186/1476-4598-13-41.


Taccalonolide microtubule stabilizers.

Li J, Risinger AL, Mooberry SL.

Bioorg Med Chem. 2014 Sep 15;22(18):5091-6. doi: 10.1016/j.bmc.2014.01.012. Epub 2014 Jan 15. Review.


Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.

Rohena CC, Mooberry SL.

Nat Prod Rep. 2014 Mar;31(3):335-55. doi: 10.1039/c3np70092e. Review.


Design, synthesis, and biological evaluation of bone-targeted proteasome inhibitors for multiple myeloma.

Agyin JK, Santhamma B, Roy SS.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6455-8. doi: 10.1016/j.bmcl.2013.09.043. Epub 2013 Sep 21.


The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions.

Risinger AL, Peng J, Rohena CC, Aguilar HR, Frantz DE, Mooberry SL.

J Nat Prod. 2013 Oct 25;76(10):1923-9. doi: 10.1021/np4005079. Epub 2013 Oct 2.

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