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Items: 1 to 20 of 90


Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.

Sud A, Thomsen H, Law PJ, Försti A, Filho MIDS, Holroyd A, Broderick P, Orlando G, Lenive O, Wright L, Cooke R, Easton D, Pharoah P, Dunning A, Peto J, Canzian F, Eeles R, Kote-Jarai Z, Muir K, Pashayan N; PRACTICAL consortium, Hoffmann P, Nöthen MM, Jöckel KH, Strandmann EPV, Lightfoot T, Kane E, Roman E, Lake A, Montgomery D, Jarrett RF, Swerdlow AJ, Engert A, Orr N, Hemminki K, Houlston RS.

Nat Commun. 2017 Dec 1;8(1):1892. doi: 10.1038/s41467-017-00320-1.


Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens.

Liu G, Wang X, Liu Y, Zhang M, Cai T, Shen Z, Jia Y, Huang Y.

Nucleic Acids Res. 2017 Dec 15;45(22):e180. doi: 10.1093/nar/gkx857.


BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres.

Sobinoff AP, Allen JA, Neumann AA, Yang SF, Walsh ME, Henson JD, Reddel RR, Pickett HA.

EMBO J. 2017 Oct 2;36(19):2907-2919. doi: 10.15252/embj.201796889. Epub 2017 Sep 6.


Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life.

Ahmad M, Xu D, Wang W.

RNA Biol. 2017 Jul 3;14(7):854-864. doi: 10.1080/15476286.2017.1330741. Epub 2017 May 23.


Human Cell Assays for Synthesis-Dependent Strand Annealing and Crossing over During Double-Strand Break Repair.

Zapotoczny G, Sekelsky J.

G3 (Bethesda). 2017 Apr 3;7(4):1191-1199. doi: 10.1534/g3.116.037390.


Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor.

Goto-Ito S, Yamagata A, Takahashi TS, Sato Y, Fukai S.

Sci Rep. 2017 Feb 8;7:42123. doi: 10.1038/srep42123.


Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks.

Ling C, Huang J, Yan Z, Li Y, Ohzeki M, Ishiai M, Xu D, Takata M, Seidman M, Wang W.

Cell Discov. 2016 Dec 20;2:16047. doi: 10.1038/celldisc.2016.47. eCollection 2016.


Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome.

Hudson DF, Amor DJ, Boys A, Butler K, Williams L, Zhang T, Kalitsis P.

PLoS Genet. 2016 Dec 15;12(12):e1006483. doi: 10.1371/journal.pgen.1006483. eCollection 2016 Dec.


The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana.

Röhrig S, Schröpfer S, Knoll A, Puchta H.

PLoS Genet. 2016 Oct 19;12(10):e1006394. doi: 10.1371/journal.pgen.1006394. eCollection 2016 Oct.


ETAA1 acts at stalled replication forks to maintain genome integrity.

Bass TE, Luzwick JW, Kavanaugh G, Carroll C, Dungrawala H, Glick GG, Feldkamp MD, Putney R, Chazin WJ, Cortez D.

Nat Cell Biol. 2016 Nov;18(11):1185-1195. doi: 10.1038/ncb3415. Epub 2016 Oct 10.


Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.

de Renty C, Ellis NA.

Ageing Res Rev. 2017 Jan;33:36-51. doi: 10.1016/j.arr.2016.05.010. Epub 2016 May 26. Review.


Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.

Jagut M, Hamminger P, Woglar A, Millonigg S, Paulin L, Mikl M, Dello Stritto MR, Tang L, Habacher C, Tam A, Gallach M, von Haeseler A, Villeneuve AM, Jantsch V.

PLoS Biol. 2016 Mar 24;14(3):e1002412. doi: 10.1371/journal.pbio.1002412. eCollection 2016 Mar.


A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

Voter AF, Manthei KA, Keck JL.

J Biomol Screen. 2016 Jul;21(6):626-33. doi: 10.1177/1087057116635503. Epub 2016 Mar 8.


Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis.

Xu C, Wang Y, Wang L, Wang Q, Du LQ, Fan S, Liu Q, Li L.

Int J Mol Sci. 2015 Nov 4;16(11):26395-405. doi: 10.3390/ijms161125965.


An Overview of the Molecular Mechanisms of Recombinational DNA Repair.

Kowalczykowski SC.

Cold Spring Harb Perspect Biol. 2015 Nov 2;7(11). pii: a016410. doi: 10.1101/cshperspect.a016410. Review.


Meiotic Recombination: The Essence of Heredity.

Hunter N.

Cold Spring Harb Perspect Biol. 2015 Oct 28;7(12). pii: a016618. doi: 10.1101/cshperspect.a016618. Review.


Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.

Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT.

J Exp Med. 2015 Oct 19;212(11):1967-85. doi: 10.1084/jem.20141898. Epub 2015 Oct 12.


Functions and regulation of the multitasking FANCM family of DNA motor proteins.

Xue X, Sung P, Zhao X.

Genes Dev. 2015 Sep 1;29(17):1777-88. doi: 10.1101/gad.266593.115. Review.


Biochemical mechanism of DSB end resection and its regulation.

Daley JM, Niu H, Miller AS, Sung P.

DNA Repair (Amst). 2015 Aug;32:66-74. doi: 10.1016/j.dnarep.2015.04.015. Epub 2015 May 1. Review.


Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.

Newman JA, Savitsky P, Allerston CK, Bizard AH, Özer Ö, Sarlós K, Liu Y, Pardon E, Steyaert J, Hickson ID, Gileadi O.

Nucleic Acids Res. 2015 May 26;43(10):5221-35. doi: 10.1093/nar/gkv373. Epub 2015 Apr 21.

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