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Items: 17


Structural basis of human γ-secretase assembly.

Sun L, Zhao L, Yang G, Yan C, Zhou R, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6003-8. doi: 10.1073/pnas.1506242112.


Three-dimensional structure of human γ-secretase.

Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SH, Shi Y.

Nature. 2014 Aug 14;512(7513):166-70. doi: 10.1038/nature13567.


Toward the structure of presenilin/γ-secretase and presenilin homologs.

Wolfe MS.

Biochim Biophys Acta. 2013 Dec;1828(12):2886-97. doi: 10.1016/j.bbamem.2013.04.015. Review.


Biological function of Presenilin and its role in AD pathogenesis.

Zhang S, Zhang M, Cai F, Song W.

Transl Neurodegener. 2013 Jul 17;2(1):15. doi: 10.1186/2047-9158-2-15.


The very many faces of presenilins and the γ-secretase complex.

Smolarkiewicz M, Skrzypczak T, Wojtaszek P.

Protoplasma. 2013 Oct;250(5):997-1011. doi: 10.1007/s00709-013-0494-y. Review.


Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.

Takeo K, Watanabe N, Tomita T, Iwatsubo T.

J Biol Chem. 2012 Jul 27;287(31):25834-43. doi: 10.1074/jbc.M111.336347.


Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.

Barthet G, Georgakopoulos A, Robakis NK.

Prog Neurobiol. 2012 Aug;98(2):166-75. doi: 10.1016/j.pneurobio.2012.05.006. Review.


Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

De Strooper B, Iwatsubo T, Wolfe MS.

Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304. doi: 10.1101/cshperspect.a006304. Review.


Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.

Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M.

J Biol Chem. 2011 Jul 8;286(27):24264-74. doi: 10.1074/jbc.M111.227421.


Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.

Barthet G, Shioi J, Shao Z, Ren Y, Georgakopoulos A, Robakis NK.

FASEB J. 2011 Sep;25(9):2937-46. doi: 10.1096/fj.11-183806.


Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays.

Augustin R, Lichtenthaler SF, Greeff M, Hansen J, Wurst W, Trümbach D.

Int J Alzheimers Dis. 2011 Apr 26;2011:154325. doi: 10.4061/2011/154325.


Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.

Chiang PM, Fortna RR, Price DL, Li T, Wong PC.

Neurobiol Aging. 2012 Feb;33(2):277-85. doi: 10.1016/j.neurobiolaging.2009.12.028.


Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.

Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ.

J Biol Chem. 2010 Apr 9;285(15):11378-91. doi: 10.1074/jbc.M109.088815.


Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.

Groth C, Alvord WG, Quiñones OA, Fortini ME.

Mol Pharmacol. 2010 Apr;77(4):567-74. doi: 10.1124/mol.109.062471.


Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice.

Promnares K, Kumar M, Shroder DY, Zhang X, Anderson JF, Pal U.

Mol Microbiol. 2009 Oct;74(1):112-25. doi: 10.1111/j.1365-2958.2009.06853.x.


Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.

Eggert S, Midthune B, Cottrell B, Koo EH.

J Biol Chem. 2009 Oct 16;284(42):28943-52. doi: 10.1074/jbc.M109.038646.


Toward structural elucidation of the gamma-secretase complex.

Li H, Wolfe MS, Selkoe DJ.

Structure. 2009 Mar 11;17(3):326-34. doi: 10.1016/j.str.2009.01.007. Review.

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