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Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

Vieira MN, Lyra E Silva NM, Ferreira ST, De Felice FG.

Front Aging Neurosci. 2017 Jan 31;9:7. doi: 10.3389/fnagi.2017.00007.


Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain.

Marwarha G, Claycombe K, Schommer J, Collins D, Ghribi O.

Cell Signal. 2016 Nov;28(11):1789-805. doi: 10.1016/j.cellsig.2016.08.012.


Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.

McGuire MJ, Ishii M.

Cell Mol Neurobiol. 2016 Mar;36(2):203-17. doi: 10.1007/s10571-015-0282-7. Review.


The role of leptin in central nervous system diseases.

Li XM, Yan HJ, Guo YS, Wang D.

Neuroreport. 2016 Mar 23;27(5):350-5. doi: 10.1097/WNR.0000000000000546. Review.


Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.

Platt TL, Beckett TL, Kohler K, Niedowicz DM, Murphy MP.

Neuroscience. 2016 Feb 19;315:162-74. doi: 10.1016/j.neuroscience.2015.12.011.


Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease.

Agarwal R, Talwar P, Kushwaha SS, Tripathi CB, Kukreti R.

Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):320-6. doi: 10.4103/0972-2327.157255.


Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease.

Christensen A, Pike CJ.

Front Aging Neurosci. 2015 Jul 7;7:130. doi: 10.3389/fnagi.2015.00130. Review.


The Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's Neuropathology.

Whitfield JF, Chiarini A, Dal Prà I, Armato U, Chakravarthy B.

Cells. 2015 Jul 13;4(3):253-74. doi: 10.3390/cells4030253. Review.


Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells.

Wan Z, Mah D, Simtchouk S, Kluftinger A, Little JP.

Int J Mol Sci. 2015 Jan 6;16(1):1221-31. doi: 10.3390/ijms16011221.


Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.

Maioli S, Lodeiro M, Merino-Serrais P, Falahati F, Khan W, Puerta E, Codita A, Rimondini R, Ramirez MJ, Simmons A, Gil-Bea F, Westman E, Cedazo-Minguez A; Alzheimer's Disease Neuroimaging Initiative..

Aging Cell. 2015 Feb;14(1):122-9. doi: 10.1111/acel.12281.


Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats.

Špolcová A, Mikulášková B, Kršková K, Gajdošechová L, Zórad Š, Olszanecki R, Suski M, Bujak-Giżycka B, Železná B, Maletínská L.

BMC Neurosci. 2014 Sep 25;15:111. doi: 10.1186/1471-2202-15-111.


Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease.

Kitagishi Y, Nakanishi A, Ogura Y, Matsuda S.

Alzheimers Res Ther. 2014 Jun 20;6(3):35. doi: 10.1186/alzrt265. Review.


Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential.

Johnston JM, Hu WT, Fardo DW, Greco SJ, Perry G, Montine TJ, Trojanowski JQ, Shaw LM, Ashford JW, Tezapsidis N; Alzheimer’s Disease Neuroimaging Initiative..

Curr Alzheimer Res. 2014 Feb;11(2):165-74.


Estrogen: a master regulator of bioenergetic systems in the brain and body.

Rettberg JR, Yao J, Brinton RD.

Front Neuroendocrinol. 2014 Jan;35(1):8-30. doi: 10.1016/j.yfrne.2013.08.001. Review.


Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.

Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG.

J Neurochem. 2014 Jan;128(1):162-72. doi: 10.1111/jnc.12380.


Association between leptin and delirium in elderly inpatients.

Sánchez JC, Ospina JP, González MI.

Neuropsychiatr Dis Treat. 2013;9:659-66. doi: 10.2147/NDT.S44573.


Leptin signaling and Alzheimer's disease.

Marwarha G, Ghribi O.

Am J Neurodegener Dis. 2012;1(3):245-65.


Multi-edge gene set networks reveal novel insights into global relationships between biological themes.

Parikh JR, Xia Y, Marto JA.

PLoS One. 2012;7(9):e45211. doi: 10.1371/journal.pone.0045211.


Acute leptin treatment enhances functional recovery after spinal cord injury.

Fernández-Martos CM, González P, Rodriguez FJ.

PLoS One. 2012;7(4):e35594. doi: 10.1371/journal.pone.0035594.


Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders.

Cai H, Cong WN, Ji S, Rothman S, Maudsley S, Martin B.

Curr Alzheimer Res. 2012 Jan;9(1):5-17. Review.

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