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Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.

Hill TK, Davis AL, Wheeler FB, Kelkar SS, Freund EC, Lowther WT, Kridel SJ, Mohs AM.

Mol Pharm. 2016 Mar 7;13(3):720-8. doi: 10.1021/acs.molpharmaceut.5b00447.


[(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.

Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y.

Mol Imaging Biol. 2016 Jun;18(3):360-7. doi: 10.1007/s11307-015-0915-8.


Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways.

Greening DW, Lee ST, Ji H, Simpson RJ, Rigopoulos A, Murone C, Fang C, Gong S, O'Keefe G, Scott AM.

Oncotarget. 2015 Nov 10;6(35):38166-80. doi: 10.18632/oncotarget.6241. Erratum in: Oncotarget. 2016 Jun 7;7(23):35497.


Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration.

Zaytseva YY, Harris JW, Mitov MI, Kim JT, Butterfield DA, Lee EY, Weiss HL, Gao T, Evers BM.

Oncotarget. 2015 Aug 7;6(22):18891-904.


Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.

Wellberg EA, Rudolph MC, Lewis AS, Padilla-Just N, Jedlicka P, Anderson SM.

Breast Cancer Res. 2014 Dec 4;16(6):481. doi: 10.1186/s13058-014-0481-z.


Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.

Fako VE, Zhang JT, Liu JY.

ACS Catal. 2014 Oct 3;4(10):3444-3453.


Profiling of serum metabolites in canine lymphoma using gas chromatography mass spectrometry.

Tamai R, Furuya M, Hatoya S, Akiyoshi H, Yamamoto R, Komori Y, Yokoi S, Tani K, Hirano Y, Komori M, Takenaka S.

J Vet Med Sci. 2014 Nov;76(11):1513-8.


Up-regulated FASN expression promotes transcoelomic metastasis of ovarian cancer cell through epithelial-mesenchymal transition.

Jiang L, Wang H, Li J, Fang X, Pan H, Yuan X, Zhang P.

Int J Mol Sci. 2014 Jun 27;15(7):11539-54. doi: 10.3390/ijms150711539.


Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.

Rossato FA, Zecchin KG, La Guardia PG, Ortega RM, Alberici LC, Costa RA, Catharino RR, Graner E, Castilho RF, Vercesi AE.

PLoS One. 2014 Jun 25;9(6):e101060. doi: 10.1371/journal.pone.0101060.


Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation.

Kant S, Kumar A, Singh SM.

PLoS One. 2013 Dec 3;8(12):e82396. doi: 10.1371/journal.pone.0082396.


Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.

Yoshii Y, Furukawa T, Oyama N, Hasegawa Y, Kiyono Y, Nishii R, Waki A, Tsuji AB, Sogawa C, Wakizaka H, Fukumura T, Yoshii H, Fujibayashi Y, Lewis JS, Saga T.

PLoS One. 2013 May 31;8(5):e64570. doi: 10.1371/journal.pone.0064570.


Tumor suppressive microRNA-424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase.

Long XH, Mao JH, Peng AF, Zhou Y, Huang SH, Liu ZL.

Exp Ther Med. 2013 Apr;5(4):1048-1052.


Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance.

Warmoes M, Jaspers JE, Xu G, Sampadi BK, Pham TV, Knol JC, Piersma SR, Boven E, Jonkers J, Rottenberg S, Jimenez CR.

Mol Cell Proteomics. 2013 May;12(5):1319-34. doi: 10.1074/mcp.M112.024182.


Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention.

Zhang Y, Yang JM.

Cancer Biol Ther. 2013 Feb;14(2):81-9. doi: 10.4161/cbt.22958. Review.


microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN.

Mao JH, Zhou RP, Peng AF, Liu ZL, Huang SH, Long XH, Shu Y.

Oncol Lett. 2012 Nov;4(5):1125-1129.


Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis.

Liu ZL, Wang G, Peng AF, Luo QF, Zhou Y, Huang SH.

Oncol Lett. 2012 Nov;4(5):878-882.


The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.

Seguin F, Carvalho MA, Bastos DC, Agostini M, Zecchin KG, Alvarez-Flores MP, Chudzinski-Tavassi AM, Coletta RD, Graner E.

Br J Cancer. 2012 Sep 4;107(6):977-87. doi: 10.1038/bjc.2012.355.


Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma.

Filipp FV, Ratnikov B, De Ingeniis J, Smith JW, Osterman AL, Scott DA.

Pigment Cell Melanoma Res. 2012 Nov;25(6):732-9. doi: 10.1111/pcmr.12000. Review.


Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer.

Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM.

Cancer Res. 2012 Mar 15;72(6):1504-17. doi: 10.1158/0008-5472.CAN-11-4057.


Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.

Navina S, Acharya C, DeLany JP, Orlichenko LS, Baty CJ, Shiva SS, Durgampudi C, Karlsson JM, Lee K, Bae KT, Furlan A, Behari J, Liu S, McHale T, Nichols L, Papachristou GI, Yadav D, Singh VP.

Sci Transl Med. 2011 Nov 2;3(107):107ra110. doi: 10.1126/scitranslmed.3002573.

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