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Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae.

Brilli M, Trabocchi A, Weil T, Cavalieri D, Stefanini I.

Front Pharmacol. 2017 Mar 30;8:170. doi: 10.3389/fphar.2017.00170. eCollection 2017.


Overexpression of OLE1 Enhances Cytoplasmic Membrane Stability and Confers Resistance to Cadmium in Saccharomyces cerevisiae.

Fang Z, Chen Z, Wang S, Shi P, Shen Y, Zhang Y, Xiao J, Huang Z.

Appl Environ Microbiol. 2016 Dec 15;83(1). pii: e02319-16. Print 2017 Jan 1.


Discovery and resupply of pharmacologically active plant-derived natural products: A review.

Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H.

Biotechnol Adv. 2015 Dec;33(8):1582-1614. doi: 10.1016/j.biotechadv.2015.08.001. Epub 2015 Aug 15. Review.


Whole-genome sequencing reveals that mutations in myosin-5 confer resistance to the fungicide phenamacril in Fusarium graminearum.

Zheng Z, Hou Y, Cai Y, Zhang Y, Li Y, Zhou M.

Sci Rep. 2015 Feb 4;5:8248. doi: 10.1038/srep08248.


The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.

Kallifatidis G, Hoepfner D, Jaeg T, Guzmán EA, Wright AE.

Mar Drugs. 2013 Sep 17;11(9):3500-16. doi: 10.3390/md11093500. Erratum in: Mar Drugs. 2014;12(4):2305-7.


Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.

Richie DL, Thompson KV, Studer C, Prindle VC, Aust T, Riedl R, Estoppey D, Tao J, Sexton JA, Zabawa T, Drumm J, Cotesta S, Eichenberger J, Schuierer S, Hartmann N, Movva NR, Tallarico JA, Ryder NS, Hoepfner D.

Antimicrob Agents Chemother. 2013 May;57(5):2272-80. doi: 10.1128/AAC.01809-12. Epub 2013 Mar 11.


Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism.

St Onge R, Schlecht U, Scharfe C, Evangelista M.

Molecules. 2012 Nov 5;17(11):13098-115. doi: 10.3390/molecules171113098. Review.


Quantitative- and phospho-proteomic analysis of the yeast response to the tyrosine kinase inhibitor imatinib to pharmacoproteomics-guided drug line extension.

Dos Santos SC, Mira NP, Moreira AS, Sá-Correia I.

OMICS. 2012 Oct;16(10):537-51. doi: 10.1089/omi.2012.0012. Epub 2012 Jul 9.


An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Hoepfner D, Karkare S, Helliwell SB, Pfeifer M, Trunzer M, De Bonnechose S, Zimmerlin A, Tao J, Richie D, Hofmann A, Reinker S, Frederiksen M, Movva NR, Porter JA, Ryder NS, Parker CN.

Antimicrob Agents Chemother. 2012 Aug;56(8):4233-40. doi: 10.1128/AAC.06332-11. Epub 2012 May 21.


Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology.

Dos Santos SC, Teixeira MC, Cabrito TR, Sá-Correia I.

Front Genet. 2012 Apr 19;3:63. doi: 10.3389/fgene.2012.00063. eCollection 2012.


Exploring the molecular basis of antifungal synergies using genome-wide approaches.

Agarwal AK, Tripathi SK, Xu T, Jacob MR, Li XC, Clark AM.

Front Microbiol. 2012 Mar 27;3:115. doi: 10.3389/fmicb.2012.00115. eCollection 2012.


Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.

Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, Edwards BS, Peterson BR, Aubé J, Werner-Washburne M, Loewith RJ, De Virgilio C, Sklar LA.

ACS Chem Biol. 2012 Apr 20;7(4):715-22. doi: 10.1021/cb200452r. Epub 2012 Feb 1.


Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast.

North M, Tandon VJ, Thomas R, Loguinov A, Gerlovina I, Hubbard AE, Zhang L, Smith MT, Vulpe CD.

PLoS One. 2011;6(8):e24205. doi: 10.1371/journal.pone.0024205. Epub 2011 Aug 30.


Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation.

Minear S, O'Donnell AF, Ballew A, Giaever G, Nislow C, Stearns T, Cyert MS.

Eukaryot Cell. 2011 Nov;10(11):1574-81. doi: 10.1128/EC.05163-11. Epub 2011 Sep 9.


Involvement of the pleiotropic drug resistance response, protein kinase C signaling, and altered zinc homeostasis in resistance of Saccharomyces cerevisiae to diclofenac.

van Leeuwen JS, Vermeulen NP, Vos JC.

Appl Environ Microbiol. 2011 Sep;77(17):5973-80. doi: 10.1128/AEM.00253-11. Epub 2011 Jul 1.


Functional toxicogenomics: mechanism-centered toxicology.

North M, Vulpe CD.

Int J Mol Sci. 2010;11(12):4796-813. doi: 10.3390/ijms11124796. Epub 2010 Nov 24. Review.


Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.

Kennedy MA, Kabbani N, Lambert JP, Swayne LA, Ahmed F, Figeys D, Bennett SA, Bryan J, Baetz K.

PLoS Genet. 2011 Feb 10;7(2):e1001299. doi: 10.1371/journal.pgen.1001299.


Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiae.

de Castro PA, Savoldi M, Bonatto D, Barros MH, Goldman MH, Berretta AA, Goldman GH.

Eukaryot Cell. 2011 Mar;10(3):398-411. doi: 10.1128/EC.00256-10. Epub 2010 Dec 30.


Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.

Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ.

Mol Syst Biol. 2010 Dec 21;6:451. doi: 10.1038/msb.2010.107.


Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection.

Oh J, Fung E, Schlecht U, Davis RW, Giaever G, St Onge RP, Deutschbauer A, Nislow C.

PLoS Pathog. 2010 Oct 7;6(10):e1001140. doi: 10.1371/journal.ppat.1001140.

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