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Items: 1 to 20 of 38


The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology.

Canu N, Amadoro G, Triaca V, Latina V, Sposato V, Corsetti V, Severini C, Ciotti MT, Calissano P.

Int J Mol Sci. 2017 Jun 20;18(6). pii: E1319. doi: 10.3390/ijms18061319. Review.


Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy.

Sampaio TB, Savall AS, Gutierrez MEZ, Pinton S.

Neural Regen Res. 2017 Apr;12(4):549-557. doi: 10.4103/1673-5374.205084. Review.


Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP.

Nigam SM, Xu S, Kritikou JS, Marosi K, Brodin L, Mattson MP.

J Neurochem. 2017 Jul;142(2):286-296. doi: 10.1111/jnc.14034. Epub 2017 May 18.


Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons.

Latina V, Caioli S, Zona C, Ciotti MT, Amadoro G, Calissano P.

Front Cell Neurosci. 2017 Mar 15;11:68. doi: 10.3389/fncel.2017.00068. eCollection 2017.


Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.

Matrone C, Dzamko N, Madsen P, Nyegaard M, Pohlmann R, Søndergaard RV, Lassen LB, Andresen TL, Halliday GM, Jensen PH, Nielsen MS.

PLoS One. 2016 Aug 10;11(8):e0160501. doi: 10.1371/journal.pone.0160501. eCollection 2016.


NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.

Triaca V, Sposato V, Bolasco G, Ciotti MT, Pelicci P, Bruni AC, Cupidi C, Maletta R, Feligioni M, Nisticò R, Canu N, Calissano P.

Aging Cell. 2016 Aug;15(4):661-72. doi: 10.1111/acel.12473. Epub 2016 Apr 13.


Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.

Lee IS, Jung K, Kim IS, Lee H, Kim M, Yun S, Hwang K, Shin JE, Park KI.

Mol Neurodegener. 2015 Aug 21;10:38. doi: 10.1186/s13024-015-0035-6.


The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ.

Lim JY, Reighard CP, Crowther DC.

Hum Mol Genet. 2015 Jul 15;24(14):3929-38. doi: 10.1093/hmg/ddv130. Epub 2015 May 7.


Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.

La Rosa LR, Perrone L, Nielsen MS, Calissano P, Andersen OM, Matrone C.

Front Cell Neurosci. 2015 Apr 7;9:109. doi: 10.3389/fncel.2015.00109. eCollection 2015.


Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function.

Mariga A, Zavadil J, Ginsberg SD, Chao MV.

Dev Neurobiol. 2015 Feb;75(2):173-92. doi: 10.1002/dneu.22216. Epub 2014 Aug 25.


Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability.

Rodrigues R, Petersen RB, Perry G.

Cell Mol Neurobiol. 2014 Oct;34(7):925-49. doi: 10.1007/s10571-014-0074-5. Epub 2014 Jun 14. Review.


Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF?

Markham A, Bains R, Franklin P, Spedding M.

Br J Pharmacol. 2014 Apr;171(8):2206-29. doi: 10.1111/bph.12531. Review.


Tau protein modifications and interactions: their role in function and dysfunction.

Mietelska-Porowska A, Wasik U, Goras M, Filipek A, Niewiadomska G.

Int J Mol Sci. 2014 Mar 18;15(3):4671-713. doi: 10.3390/ijms15034671. Review.


Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.

Ari C, Borysov SI, Wu J, Padmanabhan J, Potter H.

Neurobiol Aging. 2014 Aug;35(8):1839-49. doi: 10.1016/j.neurobiolaging.2014.02.006. Epub 2014 Feb 10.


MiR-21 is an Ngf-modulated microRNA that supports Ngf signaling and regulates neuronal degeneration in PC12 cells.

Montalban E, Mattugini N, Ciarapica R, Provenzano C, Savino M, Scagnoli F, Prosperini G, Carissimi C, Fulci V, Matrone C, Calissano P, Nasi S.

Neuromolecular Med. 2014 Jun;16(2):415-30. doi: 10.1007/s12017-014-8292-z. Epub 2014 Feb 4.


The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other disorders.

Scharfman HE, Chao MV.

Cogn Neurosci. 2013;4(3-4):123-35. doi: 10.1080/17588928.2013.826184. Epub 2013 Aug 25. Review.


A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein.

Matrone C.

Bioessays. 2013 Oct;35(10):847-52. doi: 10.1002/bies.201300041. Epub 2013 Aug 14.

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