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Items: 16


DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair.

Ying S, Chen Z, Medhurst AL, Neal JA, Bao Z, Mortusewicz O, McGouran J, Song X, Shen H, Hamdy FC, Kessler BM, Meek K, Helleday T.

Cancer Res. 2016 Mar 1;76(5):1078-88. doi: 10.1158/0008-5472.CAN-15-0608. Epub 2015 Nov 24.


Unifying the DNA end-processing roles of the artemis nuclease: Ku-dependent artemis resection at blunt DNA ends.

Chang HH, Watanabe G, Lieber MR.

J Biol Chem. 2015 Oct 2;290(40):24036-50. doi: 10.1074/jbc.M115.680900. Epub 2015 Aug 14.


An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.

Lu C, Ward A, Bettridge J, Liu Y, Desiderio S.

Cell Rep. 2015 Jan 6;10(1):29-38. doi: 10.1016/j.celrep.2014.12.001. Epub 2014 Dec 24.


Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.

Li S, Chang HH, Niewolik D, Hedrick MP, Pinkerton AB, Hassig CA, Schwarz K, Lieber MR.

J Biol Chem. 2014 Mar 14;289(11):7825-34. doi: 10.1074/jbc.M113.544874. Epub 2014 Feb 5.


A noncatalytic function of the ligation complex during nonhomologous end joining.

Cottarel J, Frit P, Bombarde O, Salles B, NĂ©grel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P.

J Cell Biol. 2013 Jan 21;200(2):173-86. doi: 10.1083/jcb.201203128.


Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.

Wang G, Dhar K, Swanson PC, Levitus M, Chang Y.

Nucleic Acids Res. 2012 Jul;40(13):6082-96. doi: 10.1093/nar/gks255. Epub 2012 Mar 20.


The response to and repair of RAG-mediated DNA double-strand breaks.

Helmink BA, Sleckman BP.

Annu Rev Immunol. 2012;30:175-202. doi: 10.1146/annurev-immunol-030409-101320. Epub 2012 Jan 3. Review.


DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death.

Hill R, Madureira PA, Waisman DM, Lee PW.

Oncotarget. 2011 Dec;2(12):1094-108.


N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.

Meek K, Lees-Miller SP, Modesti M.

Nucleic Acids Res. 2012 Apr;40(7):2964-73. doi: 10.1093/nar/gkr1211. Epub 2011 Dec 13.


Choosing the right path: does DNA-PK help make the decision?

Neal JA, Meek K.

Mutat Res. 2011 Jun 3;711(1-2):73-86. doi: 10.1016/j.mrfmmm.2011.02.010. Epub 2011 Mar 3. Review.


Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair.

Pawelczak KS, Turchi JJ.

DNA Repair (Amst). 2010 Jun 4;9(6):670-7. doi: 10.1016/j.dnarep.2010.03.002. Epub 2010 Mar 27.


The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

Lieber MR.

Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131. Review.


DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis.

Gu J, Li S, Zhang X, Wang LC, Niewolik D, Schwarz K, Legerski RJ, Zandi E, Lieber MR.

DNA Repair (Amst). 2010 Apr 4;9(4):429-37. doi: 10.1016/j.dnarep.2010.01.001. Epub 2010 Feb 1.


Requirement for ubiquitin conjugation and 26S proteasome activity at an early stage in V(D)J recombination.

Bhattacharyya A, Jones JM.

Mol Immunol. 2010 Mar;47(6):1173-80. doi: 10.1016/j.molimm.2010.01.004. Epub 2010 Feb 8.


The C-terminal domain of Cernunnos/XLF is dispensable for DNA repair in vivo.

Malivert L, Callebaut I, Rivera-Munoz P, Fischer A, Mornon JP, Revy P, de Villartay JP.

Mol Cell Biol. 2009 Mar;29(5):1116-22. doi: 10.1128/MCB.01521-08. Epub 2008 Dec 22.

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