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Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment.

Jiang M, Zhang WW, Liu P, Yu W, Liu T, Yu J.

Front Immunol. 2017 Feb 8;8:70. doi: 10.3389/fimmu.2017.00070. eCollection 2017. Review.


Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1.

Song S, Su Z, Xu H, Niu M, Chen X, Min H, Zhang B, Sun G, Xie S, Wang H, Gao Q.

Cell Death Dis. 2017 Feb 9;8(2):e2612. doi: 10.1038/cddis.2017.38.


Exosome-Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells.

Devhare PB, Sasaki R, Shrivastava S, Di Bisceglie AM, Ray R, Ray RB.

J Virol. 2017 Feb 28;91(6). pii: e02225-16. doi: 10.1128/JVI.02225-16. Print 2017 Mar 15. Erratum in: J Virol. 2017 Apr 28;91(10 ):.


miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis.

Ye J, Guo R, Shi Y, Qi F, Guo C, Yang L.

Mediators Inflamm. 2016;2016:8060182. Epub 2016 Oct 24.


Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway.

Malemud CJ.

Pharmaceuticals (Basel). 2010 May 12;3(5):1446-1455. Review.


Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer.

Kim MS, Jeong J, Seo J, Kim HS, Kim SJ, Jin W.

Sci Rep. 2016 Sep 22;6:33899. doi: 10.1038/srep33899.


Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing.

Feng Y, Sanders AJ, Ruge F, Morris CA, Harding KG, Jiang WG.

Int J Mol Med. 2016 Nov;38(5):1349-1358. doi: 10.3892/ijmm.2016.2733. Epub 2016 Sep 13.


Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity.

Boyraz M, Yeşilkaya E, Ezgü F, Bideci A, Doğan H, Ulucan K, Cinaz P.

J Clin Res Pediatr Endocrinol. 2016 Dec 1;8(4):452-460. doi: 10.4274/jcrpe.3167. Epub 2016 Sep 9.


Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass.

Walker EC, Johnson RW, Hu Y, Brennan HJ, Poulton IJ, Zhang JG, Jenkins BJ, Smyth GK, Nicola NA, Sims NA.

J Biol Chem. 2016 Oct 7;291(41):21703-21716. Epub 2016 Aug 18.


Prenatal high-dose vitamin D3 supplementation has balanced effects on cord blood Th1 and Th2 responses.

Akhtar E, Mily A, Haq A, Al-Mahmud A, El-Arifeen S, Hel Baqui A, Roth DE, Raqib R.

Nutr J. 2016 Aug 9;15(1):75. doi: 10.1186/s12937-016-0194-5.


JAK inhibition in the treatment of diabetic kidney disease.

Brosius FC, Tuttle KR, Kretzler M.

Diabetologia. 2016 Aug;59(8):1624-7. doi: 10.1007/s00125-016-4021-5. Epub 2016 Jun 22. Review.


Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells.

Ye C, Driver JP.

Front Immunol. 2016 May 9;7:169. doi: 10.3389/fimmu.2016.00169. eCollection 2016. Review.


Hypoxic Conditioned Medium From Human Adipose-Derived Stem Cells Promotes Mouse Liver Regeneration Through JAK/STAT3 Signaling.

Lee SC, Jeong HJ, Lee SK, Kim SJ.

Stem Cells Transl Med. 2016 Jun;5(6):816-25. doi: 10.5966/sctm.2015-0191. Epub 2016 Apr 21.


Tissue-Specific Signatures in the Transcriptional Response to Anaplasma phagocytophilum Infection of Ixodes scapularis and Ixodes ricinus Tick Cell Lines.

Alberdi P, Mansfield KL, Manzano-Román R, Cook C, Ayllón N, Villar M, Johnson N, Fooks AR, de la Fuente J.

Front Cell Infect Microbiol. 2016 Feb 10;6:20. doi: 10.3389/fcimb.2016.00020. eCollection 2016.


Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy.

Giordano C, Barone I, Vircillo V, Panza S, Malivindi R, Gelsomino L, Pellegrino M, Rago V, Mauro L, Lanzino M, Panno ML, Bonofiglio D, Catalano S, Andò S.

Sci Rep. 2016 Feb 22;6:21782. doi: 10.1038/srep21782.


The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain.

Hu S, Chen Y, Wang ZF, Mao-Ying QL, Mi WL, Jiang JW, Wu GC, Wang YQ.

Evid Based Complement Alternat Med. 2015;2015:973524. doi: 10.1155/2015/973524. Epub 2015 Nov 15.


Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer.

Kim MS, Lee WS, Jeong J, Kim SJ, Jin W.

Oncotarget. 2015 Nov 24;6(37):40158-71. doi: 10.18632/oncotarget.5522.


Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.

Kesarwani M, Huber E, Kincaid Z, Evelyn CR, Biesiada J, Rance M, Thapa MB, Shah NP, Meller J, Zheng Y, Azam M.

Sci Rep. 2015 Sep 30;5:14538. doi: 10.1038/srep14538.

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