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Items: 15


Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases.

Weber S, Meyer-Roxlau S, Wagner M, Dobrev D, El-Armouche A.

Front Pharmacol. 2015 Nov 13;6:270. doi: 10.3389/fphar.2015.00270. eCollection 2015. Review.


Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.

Copik AJ, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, Dietrich PJ, Fitch B, Raymond JR, Ford AP, Button D, Milla ME.

PLoS One. 2015 Jan 21;10(1):e0115701. doi: 10.1371/journal.pone.0115701. eCollection 2015.


Anthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling network.

Golden HB, Watson LE, Nizamutdinov D, Feng H, Gerilechaogetu F, Lal H, Verma SK, Mukhopadhyay S, Foster DM, Dillmann WH, Dostal DE.

Int J Cardiol. 2013 Oct 9;168(4):3884-95. doi: 10.1016/j.ijcard.2013.06.050. Epub 2013 Jul 30.


Compartmentalization of β-adrenergic signals in cardiomyocytes.

Fu Q, Chen X, Xiang YK.

Trends Cardiovasc Med. 2013 Oct;23(7):250-6. doi: 10.1016/j.tcm.2013.02.001. Epub 2013 Mar 23. Review.


Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart.

Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, Sun J, Hockman S, Chung YW, Movsesian M, Murphy E, Manganiello V, Backx PH.

Circ Res. 2013 Jan 18;112(2):289-97. doi: 10.1161/CIRCRESAHA.111.300003. Epub 2012 Nov 19.


Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death.

Smith S, Curran J, Hund TJ, Mohler PJ.

Front Physiol. 2012 May 3;3:122. doi: 10.3389/fphys.2012.00122. eCollection 2012.


The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases.

Rietz A, Spiers J.

Br J Pharmacol. 2012 Jun;166(4):1225-43. doi: 10.1111/j.1476-5381.2012.01917.x. Review.


Compartmentalization of beta-adrenergic signals in cardiomyocytes.

Xiang YK.

Circ Res. 2011 Jul 8;109(2):231-44. doi: 10.1161/CIRCRESAHA.110.231340. Review.


Conserved expression and functions of PDE4 in rodent and human heart.

Richter W, Xie M, Scheitrum C, Krall J, Movsesian MA, Conti M.

Basic Res Cardiol. 2011 Mar;106(2):249-62. doi: 10.1007/s00395-010-0138-8. Epub 2010 Dec 16.


Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.

Al Moamen NJ, Prasad V, Bodi I, Miller ML, Neiman ML, Lasko VM, Alper SL, Wieczorek DF, Lorenz JN, Shull GE.

J Mol Cell Cardiol. 2011 Jan;50(1):137-46. doi: 10.1016/j.yjmcc.2010.10.028. Epub 2010 Nov 4.


Regulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activation.

Haworth RS, Cuello F, Avkiran M.

Basic Res Cardiol. 2011 Jan;106(1):51-63. doi: 10.1007/s00395-010-0116-1. Epub 2010 Aug 20.


Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes.

De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK.

Mol Pharmacol. 2010 Sep;78(3):340-9. doi: 10.1124/mol.110.064444. Epub 2010 Jun 7.


cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.

Dodge-Kafka KL, Bauman A, Mayer N, Henson E, Heredia L, Ahn J, McAvoy T, Nairn AC, Kapiloff MS.

J Biol Chem. 2010 Apr 9;285(15):11078-86. doi: 10.1074/jbc.M109.034868. Epub 2010 Jan 27.


Cardiac ankyrins in health and disease.

Hashemi SM, Hund TJ, Mohler PJ.

J Mol Cell Cardiol. 2009 Aug;47(2):203-9. doi: 10.1016/j.yjmcc.2009.04.010. Epub 2009 Apr 24. Review.


Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction.

Soto D, De Arcangelis V, Zhang J, Xiang Y.

Circ Res. 2009 Mar 27;104(6):770-9. doi: 10.1161/CIRCRESAHA.108.187880. Epub 2009 Feb 12.

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