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Items: 13

1.

Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?

Sharma H, Santra S, Dutta A.

Future Med Chem. 2015;7(17):2385-406. doi: 10.4155/fmc.15.134. Epub 2015 Nov 30. Review.

2.

Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template.

Santra S, Sharma H, Vedachalam S, Antonio T, Reith M, Dutta A.

Bioorg Med Chem. 2015 Feb 15;23(4):821-8. doi: 10.1016/j.bmc.2014.12.040. Epub 2014 Dec 25.

3.

Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters.

Dutta AK, Santra S, Sharma H, Voshavar C, Xu L, Mabrouk O, Antonio T, Reith ME.

PLoS One. 2014 Nov 26;9(11):e113420. doi: 10.1371/journal.pone.0113420. eCollection 2014.

4.

Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.

Liu S, Zha C, Nacro K, Hu M, Cui W, Yang YL, Bhatt U, Sambandam A, Isherwood M, Yet L, Herr MT, Ebeltoft S, Hassler C, Fleming L, Pechulis AD, Payen-Fornicola A, Holman N, Milanowski D, Cotterill I, Mozhaev V, Khmelnitsky Y, Guzzo PR, Sargent BJ, Molino BF, Olson R, King D, Lelas S, Li YW, Johnson K, Molski T, Orie A, Ng A, Haskell R, Clarke W, Bertekap R, O'Connell J, Lodge N, Sinz M, Adams S, Zaczek R, Macor JE.

ACS Med Chem Lett. 2014 May 13;5(7):760-5. doi: 10.1021/ml500053b. eCollection 2014 Jul 10.

5.

Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model.

Sharma H, Santra S, Debnath J, Antonio T, Reith M, Dutta A.

Bioorg Med Chem. 2014 Jan 1;22(1):311-24. doi: 10.1016/j.bmc.2013.11.017. Epub 2013 Nov 19.

6.

SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity.

Fang X, Guo L, Jia J, Jin GZ, Zhao B, Zheng YY, Li JQ, Zhang A, Zhen XC.

Acta Pharmacol Sin. 2013 Sep;34(9):1149-55. doi: 10.1038/aps.2013.66. Epub 2013 Jul 29.

7.

Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants.

Santra S, Gogoi S, Gopishetty B, Antonio T, Zhen J, Reith ME, Dutta AK.

ChemMedChem. 2012 Dec;7(12):2093-100. doi: 10.1002/cmdc.201200352. Epub 2012 Oct 11.

8.

The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents.

Dutta AK, Gopishetty B, Gogoi S, Ali S, Zhen J, Reith M.

Eur J Pharmacol. 2011 Dec 5;671(1-3):39-44. doi: 10.1016/j.ejphar.2011.09.162. Epub 2011 Sep 24.

9.

Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.

Gopishetty B, Hazeldine S, Santra S, Johnson M, Modi G, Ali S, Zhen J, Reith M, Dutta A.

J Med Chem. 2011 Apr 28;54(8):2924-32. doi: 10.1021/jm200020a. Epub 2011 Mar 29.

10.
11.

Stereoselective synthesis of β-hydroxy enamines, aminocyclopropanes, and 1,3-amino alcohols via asymmetric catalysis.

Valenta P, Carroll PJ, Walsh PJ.

J Am Chem Soc. 2010 Oct 13;132(40):14179-90. doi: 10.1021/ja105435y.

12.

Emerging targets for antidepressant therapies.

Rakofsky JJ, Holtzheimer PE, Nemeroff CB.

Curr Opin Chem Biol. 2009 Jun;13(3):291-302. doi: 10.1016/j.cbpa.2009.04.617. Epub 2009 Jun 6. Review.

13.

Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs?

Van der Schyf CJ, Geldenhuys WJ.

Neurotherapeutics. 2009 Jan;6(1):175-86. doi: 10.1016/j.nurt.2008.10.037. Review.

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