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Items: 1 to 20 of 22


Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density.

Hottman D, Cheng S, Gram A, LeBlanc K, Yuan LL, Li L.

Neuroscience. 2018 Mar 1;373:207-217. doi: 10.1016/j.neuroscience.2018.01.026. Epub 2018 Feb 2.


Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).

Mast N, Lin JB, Anderson KW, Bjorkhem I, Pikuleva IA.

PLoS One. 2017 Oct 26;12(10):e0187168. doi: 10.1371/journal.pone.0187168. eCollection 2017. Erratum in: PLoS One. 2018 Jan 5;13(1):e0191058.


Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease.

Mast N, Saadane A, Valencia-Olvera A, Constans J, Maxfield E, Arakawa H, Li Y, Landreth G, Pikuleva IA.

Neuropharmacology. 2017 Sep 1;123:465-476. doi: 10.1016/j.neuropharm.2017.06.026. Epub 2017 Jun 24.


In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.

Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA.

J Biol Chem. 2017 Aug 4;292(31):12934-12946. doi: 10.1074/jbc.M117.794909. Epub 2017 Jun 22.


Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Ruas JL, Rodrigues E.

Sci Rep. 2016 Aug 5;6:30928. doi: 10.1038/srep30928.


Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices.

Sun MY, Izumi Y, Benz A, Zorumski CF, Mennerick S.

J Neurophysiol. 2016 Mar;115(3):1263-72. doi: 10.1152/jn.00890.2015. Epub 2015 Dec 23.


24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival.

Sun MY, Linsenbardt AJ, Emnett CM, Eisenman LN, Izumi Y, Zorumski CF, Mennerick S.

Neuroscientist. 2016 Apr;22(2):132-44. doi: 10.1177/1073858414568122. Epub 2015 Jan 27. Review.


Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum.

Bandaru VV, Haughey NJ.

BMC Neurosci. 2014 Dec 24;15:137. doi: 10.1186/s12868-014-0137-z.


Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse.

Meljon A, Wang Y, Griffiths WJ.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):768-74. doi: 10.1016/j.bbrc.2014.01.153. Epub 2014 Jan 31.


Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.

Wood WG, Li L, Müller WE, Eckert GP.

J Neurochem. 2014 May;129(4):559-72. doi: 10.1111/jnc.12637. Epub 2014 Jan 2. Review.


Acute and chronic oral toxicity of a partially purified plaunotol extract from Croton stellatopilosus Ohba.

Chaotham C, Chivapat S, Chaikitwattana A, De-Eknamkul W.

Biomed Res Int. 2013;2013:303162. doi: 10.1155/2013/303162. Epub 2013 Sep 30.


The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.

Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF.

J Neurosci. 2013 Oct 30;33(44):17290-300. doi: 10.1523/JNEUROSCI.2619-13.2013.


Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging.

Chen KC, Blalock EM, Curran-Rauhut MA, Kadish I, Blalock SJ, Brewer L, Porter NM, Landfield PW.

Endocrinology. 2013 Aug;154(8):2807-20. doi: 10.1210/en.2013-1139. Epub 2013 Jun 4.


Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.

Pierrot N, Tyteca D, D'auria L, Dewachter I, Gailly P, Hendrickx A, Tasiaux B, Haylani LE, Muls N, N'kuli F, Laquerrière A, Demoulin JB, Campion D, Brion JP, Courtoy PJ, Kienlen-Campard P, Octave JN.

EMBO Mol Med. 2013 Apr;5(4):608-25. doi: 10.1002/emmm.201202215.


In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine.

Mast N, Linger M, Clark M, Wiseman J, Stout CD, Pikuleva IA.

Mol Pharmacol. 2012 Nov;82(5):824-34. doi: 10.1124/mol.112.080424. Epub 2012 Aug 2.


Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.

Nunes MJ, Moutinho M, Milagre I, Gama MJ, Rodrigues E.

J Lipid Res. 2012 Sep;53(9):1910-9. doi: 10.1194/jlr.M027680. Epub 2012 Jun 12.


Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.

Li L, Zhang W, Cheng S, Cao D, Parent M.

Mol Neurobiol. 2012 Aug;46(1):64-77. doi: 10.1007/s12035-012-8253-1. Epub 2012 Mar 15. Review.


Isoprenoids, small GTPases and Alzheimer's disease.

Hooff GP, Wood WG, Müller WE, Eckert GP.

Biochim Biophys Acta. 2010 Aug;1801(8):896-905. doi: 10.1016/j.bbalip.2010.03.014. Epub 2010 Apr 8. Review.


Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice.

Mans RA, Chowdhury N, Cao D, McMahon LL, Li L.

Neuroscience. 2010 Mar 17;166(2):435-44. doi: 10.1016/j.neuroscience.2009.12.062. Epub 2009 Dec 28.


Regulation of protein prenyltransferase in central neurons.

Zhou XP, Luo ZG.

Commun Integr Biol. 2009;2(2):138-40.

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