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Items: 1 to 20 of 113


Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes.

Hoffman H, Rice C, Skordalakes E.

J Biol Chem. 2017 Mar 17;292(11):4593-4601. doi: 10.1074/jbc.M116.771204. Epub 2017 Feb 1.


Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis.

Mora AL, Bueno M, Rojas M.

J Clin Invest. 2017 Feb 1;127(2):405-414. doi: 10.1172/JCI87440. Epub 2017 Feb 1. Review.


Telomerase and the Genetics of Emphysema Susceptibility. Implications for Pathogenesis Paradigms and Patient Care.

Stanley SE, Merck SJ, Armanios M.

Ann Am Thorac Soc. 2016 Dec;13(Supplement_5):S447-S451. doi: 10.1513/AnnalsATS.201609-718AW.


Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.

Xu Y, Mizuno T, Sridharan A, Du Y, Guo M, Tang J, Wikenheiser-Brokamp KA, Perl AT, Funari VA, Gokey JJ, Stripp BR, Whitsett JA.

JCI Insight. 2016 Dec 8;1(20):e90558.


Pulmonary fibrosis in the era of stratified medicine.

Mathai SK, Newton CA, Schwartz DA, Garcia CK.

Thorax. 2016 Dec;71(12):1154-1160. doi: 10.1136/thoraxjnl-2016-209172. Epub 2016 Oct 31. Review.


Genetic Evaluation and Testing of Patients and Families with Idiopathic Pulmonary Fibrosis.

Kropski JA, Young LR, Cogan JD, Mitchell DB, Lancaster LH, Worrell JA, Markin C, Liu N, Mason WR, Fingerlin TE, Schwartz DA, Lawson WE, Blackwell TS, Phillips JA 3rd, Loyd JE.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1423-1428. doi: 10.1164/rccm.201609-1820PP. No abstract available.


Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis.

Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ.

JCI Insight. 2016 Sep 8;1(14):e86704.


Idiopathic Pulmonary Fibrosis: Diagnosis and Clinical Manifestations.

Nakamura Y, Suda T.

Clin Med Insights Circ Respir Pulm Med. 2016 Sep 6;9(Suppl 1):163-71. doi: 10.4137/CCRPM.S39897. eCollection 2015. Review.


Association of Donor and Recipient Telomere Length with Clinical Outcomes following Lung Transplantation.

Courtwright AM, Fried S, Villalba JA, Moniodis A, Guleria I, Wood I, Milford E, Mallidi HH, Hunninghake GM, Raby BA, Agarwal S, Camp PC, Rosas IO, Goldberg HJ, El-Chemaly S.

PLoS One. 2016 Sep 2;11(9):e0162409. doi: 10.1371/journal.pone.0162409. eCollection 2016.


Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.

Newton CA, Batra K, Torrealba J, Kozlitina J, Glazer CS, Aravena C, Meyer K, Raghu G, Collard HR, Garcia CK.

Eur Respir J. 2016 Dec;48(6):1710-1720. doi: 10.1183/13993003.00308-2016. Epub 2016 Aug 18.


Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema.

Stanley SE, Gable DL, Wagner CL, Carlile TM, Hanumanthu VS, Podlevsky JD, Khalil SE, DeZern AE, Rojas-Duran MF, Applegate CD, Alder JK, Parry EM, Gilbert WV, Armanios M.

Sci Transl Med. 2016 Aug 10;8(351):351ra107. doi: 10.1126/scitranslmed.aaf7837.


miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.

Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ.

PLoS One. 2016 Jun 30;11(6):e0158367. doi: 10.1371/journal.pone.0158367. eCollection 2016.


Shorter Remission Telomere Length Predicts Delayed Neutrophil Recovery After Acute Myeloid Leukemia Therapy: A Report From the Children's Oncology Group.

Gerbing RB, Alonzo TA, Sung L, Gamis AS, Meshinchi S, Plon SE, Bertuch AA, Gramatges MM.

J Clin Oncol. 2016 Jun 27. pii: JCO669622. [Epub ahead of print]


Getting to the core of fibrosis: targeting redox imbalance in aging.

Hecker L, Thannickal VJ.

Ann Transl Med. 2016 Mar;4(5):93. doi: 10.21037/atm.2015.12.45. No abstract available.


Precision Medicine: The New Frontier in Idiopathic Pulmonary Fibrosis.

Brownell R, Kaminski N, Woodruff PG, Bradford WZ, Richeldi L, Martinez FJ, Collard HR.

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1213-8. doi: 10.1164/rccm.201601-0169CI. Review.


MUC5B and Idiopathic Pulmonary Fibrosis.

Yang IV, Fingerlin TE, Evans CM, Schwarz MI, Schwartz DA.

Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S193-9. doi: 10.1513/AnnalsATS.201503-110AW.


Conditional Knockout of Telomerase Reverse Transcriptase in Mesenchymal Cells Impairs Mouse Pulmonary Fibrosis.

Liu T, Yu H, Ding L, Wu Z, Gonzalez De Los Santos F, Liu J, Ullenbruch M, Hu B, Martins V, Phan SH.

PLoS One. 2015 Nov 10;10(11):e0142547. doi: 10.1371/journal.pone.0142547. eCollection 2015.


Understanding Idiopathic Interstitial Pneumonia: A Gene-Based Review of Stressed Lungs.

van Moorsel CH, Hoffman TW, van Batenburg AA, Klay D, van der Vis JJ, Grutters JC.

Biomed Res Int. 2015;2015:304186. doi: 10.1155/2015/304186. Epub 2015 Oct 11. Review.


Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion.

Chen J, Bryant MA, Dent JJ, Sun Y, Desierto MJ, Young NS.

Exp Gerontol. 2015 Dec;72:251-60. doi: 10.1016/j.exger.2015.10.016. Epub 2015 Oct 30.


Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.

Chen R, Zhang K, Chen H, Zhao X, Wang J, Li L, Cong Y, Ju Z, Xu D, Williams BR, Jia J, Liu JP.

J Biol Chem. 2015 Dec 25;290(52):30813-29. doi: 10.1074/jbc.M115.681619. Epub 2015 Oct 30.

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