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Items: 1 to 20 of 69


Network-assisted target identification for haploinsufficiency and homozygous profiling screens.

Wang S, Peng J.

PLoS Comput Biol. 2017 Jun 2;13(6):e1005553. doi: 10.1371/journal.pcbi.1005553. eCollection 2017 Jun.


Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant.

Wong LH, Flibotte S, Sinha S, Chiang J, Giaever G, Nislow C.

G3 (Bethesda). 2017 Apr 3;7(4):1251-1257. doi: 10.1534/g3.116.038117.


Dual mechanisms regulate the recruitment of spindle assembly checkpoint proteins to the budding yeast kinetochore.

Aravamudhan P, Chen R, Roy B, Sim J, Joglekar AP.

Mol Biol Cell. 2016 Nov 7;27(22):3405-3417. Epub 2016 May 11.


Utilizing yeast chemogenomic profiles for the prediction of pharmacogenomic associations in humans.

Silberberg Y, Kupiec M, Sharan R.

Sci Rep. 2016 Mar 30;6:23703. doi: 10.1038/srep23703.


Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.

Smith JD, Suresh S, Schlecht U, Wu M, Wagih O, Peltz G, Davis RW, Steinmetz LM, Parts L, St Onge RP.

Genome Biol. 2016 Mar 8;17:45. doi: 10.1186/s13059-016-0900-9.


Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors.

Khan D, McGrath KR, Dorosheva O, Bankaitis VA, Tripathi A.

J Lipid Res. 2016 Apr;57(4):650-62. doi: 10.1194/jlr.M066381. Epub 2016 Feb 26.


TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.

Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, Boone C, Ammerer G, Baranov PV, Loewith R.

Mol Biol Cell. 2016 Jan 15;27(2):397-409. doi: 10.1091/mbc.E15-08-0594. Epub 2015 Nov 18.


Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Mismatch Repair Mutants.

Ojini I, Gammie A.

G3 (Bethesda). 2015 Jul 21;5(9):1925-35. doi: 10.1534/g3.115.020560.


An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.

Kofoed M, Milbury KL, Chiang JH, Sinha S, Ben-Aroya S, Giaever G, Nislow C, Hieter P, Stirling PC.

G3 (Bethesda). 2015 Jul 14;5(9):1879-87. doi: 10.1534/g3.115.019174.


Magnetic levitation of single cells.

Durmus NG, Tekin HC, Guven S, Sridhar K, Arslan Yildiz A, Calibasi G, Ghiran I, Davis RW, Steinmetz LM, Demirci U.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3661-8. doi: 10.1073/pnas.1509250112. Epub 2015 Jun 29.


Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.

Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D.

J Cell Sci. 2015 Mar 15;128(6):1217-29. doi: 10.1242/jcs.165746. Epub 2015 Jan 22.


Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.

Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM.

Nat Commun. 2014 Dec 18;5:5585. doi: 10.1038/ncomms6585.


Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae.

Wride DA, Pourmand N, Bray WM, Kosarchuk JJ, Nisam SC, Quan TK, Berkeley RF, Katzman S, Hartzog GA, Dobkin CE, Scott Lokey R.

Mol Biosyst. 2014 Dec;10(12):3179-87. doi: 10.1039/c4mb00146j.


A genome scale overexpression screen to reveal drug activity in human cells.

Arnoldo A, Kittanakom S, Heisler LE, Mak AB, Shukalyuk AI, Torti D, Moffat J, Giaever G, Nislow C.

Genome Med. 2014 Apr 29;6(4):32. doi: 10.1186/gm549. eCollection 2014.


A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

Schlecht U, Suresh S, Xu W, Aparicio AM, Chu A, Proctor MJ, Davis RW, Scharfe C, St Onge RP.

BMC Genomics. 2014 Apr 5;15:263. doi: 10.1186/1471-2164-15-263.


An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae.

Wilkening S, Lin G, Fritsch ES, Tekkedil MM, Anders S, Kuehn R, Nguyen M, Aiyar RS, Proctor M, Sakhanenko NA, Galas DJ, Gagneur J, Deutschbauer A, Steinmetz LM.

Genetics. 2014 Mar;196(3):853-65. doi: 10.1534/genetics.113.160291. Epub 2013 Dec 27.


PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Nile AH, Tripathi A, Yuan P, Mousley CJ, Suresh S, Wallace IM, Shah SD, Pohlhaus DT, Temple B, Nislow C, Giaever G, Tropsha A, Davis RW, St Onge RP, Bankaitis VA.

Nat Chem Biol. 2014 Jan;10(1):76-84. doi: 10.1038/nchembio.1389. Epub 2013 Nov 24.


Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.

Zlitni S, Ferruccio LF, Brown ED.

Nat Chem Biol. 2013 Dec;9(12):796-804. doi: 10.1038/nchembio.1361. Epub 2013 Oct 13.


A novel small molecule methyltransferase is important for virulence in Candida albicans.

Lissina E, Weiss D, Young B, Rella A, Cheung-Ong K, Del Poeta M, Clarke SG, Giaever G, Nislow C.

ACS Chem Biol. 2013 Dec 20;8(12):2785-93. doi: 10.1021/cb400607h. Epub 2013 Oct 16.


Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease.

Tardiff DF, Lindquist S.

Drug Discov Today Technol. 2013 Spring;10(1):e121-8. doi: 10.1016/j.ddtec.2012.02.003. Review.

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