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Interactions between Retroviruses and the Host Cell Genome.

Poletti V, Mavilio F.

Mol Ther Methods Clin Dev. 2017 Oct 5;8:31-41. doi: 10.1016/j.omtm.2017.10.001. eCollection 2018 Mar 16. Review.


Generation of transgenic marmosets expressing genetically encoded calcium indicators.

Park JE, Zhang XF, Choi SH, Okahara J, Sasaki E, Silva AC.

Sci Rep. 2016 Oct 11;6:34931. doi: 10.1038/srep34931.


Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies.

Kiem HP, Arumugam PI, Burtner CR, Fox CF, Beard BC, Dexheimer P, Adair JE, Malik P.

Mol Ther Methods Clin Dev. 2014 Dec 17;1:14055. doi: 10.1038/mtm.2014.55. eCollection 2014.


Alpharetroviral vectors: from a cancer-causing agent to a useful tool for human gene therapy.

Suerth JD, Labenski V, Schambach A.

Viruses. 2014 Dec 5;6(12):4811-38. doi: 10.3390/v6124811. Review.


Genome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells.

Moiani A, Suerth JD, Gandolfi F, Rizzi E, Severgnini M, De Bellis G, Schambach A, Mavilio F.

Genes (Basel). 2014 May 16;5(2):415-29. doi: 10.3390/genes5020415.


Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases.

Williams DA, Thrasher AJ.

Stem Cells Transl Med. 2014 May;3(5):636-42. doi: 10.5966/sctm.2013-0206. Epub 2014 Mar 28. Review.


Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models.

Larochelle A, Dunbar CE.

Semin Hematol. 2013 Apr;50(2):101-30. Review. No abstract available.


A large-scale zebrafish gene knockout resource for the genome-wide study of gene function.

Varshney GK, Lu J, Gildea DE, Huang H, Pei W, Yang Z, Huang SC, Schoenfeld D, Pho NH, Casero D, Hirase T, Mosbrook-Davis D, Zhang S, Jao LE, Zhang B, Woods IG, Zimmerman S, Schier AF, Wolfsberg TG, Pellegrini M, Burgess SM, Lin S.

Genome Res. 2013 Apr;23(4):727-35. doi: 10.1101/gr.151464.112. Epub 2013 Feb 4.


Biosafety features of lentiviral vectors.

Schambach A, Zychlinski D, Ehrnstroem B, Baum C.

Hum Gene Ther. 2013 Feb;24(2):132-42. doi: 10.1089/hum.2012.229. Review.


Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses.

Bueno MT, Reyes D, Valdes L, Saheba A, Urias E, Mendoza C, Fregoso OI, Llano M.

J Virol. 2013 Mar;87(5):2496-507. doi: 10.1128/JVI.01668-12. Epub 2012 Dec 19.


Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.

Barese CN, Krouse AE, Metzger ME, King CA, Traversari C, Marini FC, Donahue RE, Dunbar CE.

Mol Ther. 2012 Oct;20(10):1932-43. doi: 10.1038/mt.2012.166. Epub 2012 Aug 21.


Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia.

Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, Knoess S, Krause J, Li Z, Schlegelberger B, Baum C, Modlich U.

Mol Ther. 2012 Jun;20(6):1187-95. doi: 10.1038/mt.2012.59. Epub 2012 Apr 3.


Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

Suerth JD, Maetzig T, Brugman MH, Heinz N, Appelt JU, Kaufmann KB, Schmidt M, Grez M, Modlich U, Baum C, Schambach A.

Mol Ther. 2012 May;20(5):1022-32. doi: 10.1038/mt.2011.309. Epub 2012 Feb 14.


Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.

Wu C, Dunbar CE.

Front Med. 2011 Dec;5(4):356-71. doi: 10.1007/s11684-011-0159-1. Epub 2011 Dec 27. Review.


Hematopoietic stem cell engineering at a crossroads.

Rivière I, Dunbar CE, Sadelain M.

Blood. 2012 Feb 2;119(5):1107-16. doi: 10.1182/blood-2011-09-349993. Epub 2011 Nov 17. Review.


Contributions of gene marking to cell and gene therapies.

Barese CN, Dunbar CE.

Hum Gene Ther. 2011 Jun;22(6):659-68. doi: 10.1089/hum.2010.237. Epub 2011 May 5. Review.


Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.

Sellers S, Gomes TJ, Larochelle A, Lopez R, Adler R, Krouse A, Donahue RE, Childs RW, Dunbar CE.

Mol Ther. 2010 Sep;18(9):1633-9. doi: 10.1038/mt.2010.117. Epub 2010 Jun 22.


Large animal models of hematopoietic stem cell gene therapy.

Trobridge GD, Kiem HP.

Gene Ther. 2010 Aug;17(8):939-48. doi: 10.1038/gt.2010.47. Epub 2010 Apr 29. Review.


Self-inactivating alpharetroviral vectors with a split-packaging design.

Suerth JD, Maetzig T, Galla M, Baum C, Schambach A.

J Virol. 2010 Jul;84(13):6626-35. doi: 10.1128/JVI.00182-10. Epub 2010 Apr 21.


Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas.

Plachy J, Kotáb J, Divina P, Reinisová M, Senigl F, Hejnar J.

J Virol. 2010 May;84(9):4204-11. doi: 10.1128/JVI.02511-09. Epub 2010 Feb 10.

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