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Items: 16


Cyp1b1-mediated suppression of lymphoid progenitors in bone marrow by polycyclic aromatic hydrocarbons coordinately impacts spleen and thymus: a selective role for the Ah Receptor.

Larsen MC, N'Jai AU, Alexander DL, Rondelli CM, Forsberg EC, Czuprynski CJ, Jefcoate CR.

Pharmacol Res Perspect. 2016 Jul 29;4(4):e00245. doi: 10.1002/prp2.245. eCollection 2016 Aug.


Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects.

Bolton JL, Dunlap T.

Chem Res Toxicol. 2017 Jan 17;30(1):13-37. doi: 10.1021/acs.chemrestox.6b00256. Epub 2016 Sep 29.


Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases.

Rudra A, Hou D, Zhang Y, Coulter J, Zhou H, DeWeese TL, Greenberg MM.

J Org Chem. 2015 Nov 6;80(21):10675-85. doi: 10.1021/acs.joc.5b01833. Epub 2015 Oct 28.


Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.

Penning TM.

Chem Res Toxicol. 2014 Nov 17;27(11):1901-17. doi: 10.1021/tx500298n. Epub 2014 Oct 16. Review.


Synthesis of 13C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene.

Wu A, Xu D, Lu D, Penning TM, Blair IA, Harvey RG.

Tetrahedron. 2012 Sep 1;68(35). doi: 10.1016/j.tet.2012.05.130.


Voltammetric microwell array for oxidized guanosine in intact ds-DNA.

Song B, Pan S, Tang C, Li D, Rusling JF.

Anal Chem. 2013 Nov 19;85(22):11061-7. doi: 10.1021/ac402736q. Epub 2013 Oct 28.


Interception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cells.

Zhang L, Huang M, Blair IA, Penning TM.

Chem Res Toxicol. 2013 Oct 21;26(10):1570-8. doi: 10.1021/tx400268q. Epub 2013 Oct 3.


Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JC.

Wilk A, Waligórski P, Lassak A, Vashistha H, Lirette D, Tate D, Zea AH, Koochekpour S, Rodriguez P, Meggs LG, Estrada JJ, Ochoa A, Reiss K.

J Cell Physiol. 2013 Nov;228(11):2127-38. doi: 10.1002/jcp.24375.


The role of base excision repair genes OGG1, APN1 and APN2 in benzo[a]pyrene-7,8-dione induced p53 mutagenesis.

Abedin Z, Louis-Juste M, Stangl M, Field J.

Mutat Res. 2013 Jan 20;750(1-2):121-8. doi: 10.1016/j.mrgentox.2012.10.003. Epub 2012 Oct 29.


p53 Mutagenesis by benzo[a]pyrene derived radical cations.

Sen S, Bhojnagarwala P, Francey L, Lu D, Penning TM, Field J.

Chem Res Toxicol. 2012 Oct 15;25(10):2117-26. doi: 10.1021/tx300201p. Epub 2012 Aug 9.


Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.

Abedin Z, Sen S, Field J.

Chem Res Toxicol. 2012 Jan 13;25(1):113-21. doi: 10.1021/tx200272v. Epub 2011 Nov 16.


Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.

Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.

Chem Res Toxicol. 2011 Dec 19;24(12):2153-66. doi: 10.1021/tx200294c. Epub 2011 Sep 29.


Formation and repair of tobacco carcinogen-derived bulky DNA adducts.

Hang B.

J Nucleic Acids. 2010 Dec 20;2010:709521. doi: 10.4061/2010/709521.


Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione.

Park JH, Mangal D, Frey AJ, Harvey RG, Blair IA, Penning TM.

J Biol Chem. 2009 Oct 23;284(43):29725-34. doi: 10.1074/jbc.M109.042143. Epub 2009 Sep 2.


Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress.

Mangal D, Vudathala D, Park JH, Lee SH, Penning TM, Blair IA.

Chem Res Toxicol. 2009 May;22(5):788-97. doi: 10.1021/tx800343c.


Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.

Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6846-51. doi: 10.1073/pnas.0802776105. Epub 2008 May 12.

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