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Items: 14


Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines.

Ansell BR, Baker L, Emery SJ, McConville MJ, Svärd SG, Gasser RB, Jex AR.

Front Microbiol. 2017 Mar 17;8:398. doi: 10.3389/fmicb.2017.00398. eCollection 2017.


Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target.

Leitsch D, Müller J, Müller N.

Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):148-153. doi: 10.1016/j.ijpddr.2016.07.003. Epub 2016 Jul 22.


Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds.

Müller J, Rout S, Leitsch D, Vaithilingam J, Hehl A, Müller N.

Int J Parasitol Drugs Drug Resist. 2015 Mar 25;5(2):37-43. doi: 10.1016/j.ijpddr.2015.03.001. eCollection 2015 Aug.


Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites.

Ansell BR, McConville MJ, Baker L, Korhonen PK, Young ND, Hall RS, Rojas CA, Svärd SG, Gasser RB, Jex AR.

PLoS Negl Trop Dis. 2015 Dec 4;9(12):e0004261. doi: 10.1371/journal.pntd.0004261. eCollection 2015 Dec.


Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and Giardia.

Miyamoto Y, Eckmann L.

Front Microbiol. 2015 Nov 19;6:1208. doi: 10.3389/fmicb.2015.01208. eCollection 2015. Review.


Drug Resistance in the Microaerophilic Parasite Giardia lamblia.

Leitsch D.

Curr Trop Med Rep. 2015;2(3):128-135. Review.


Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance.

Penuliar GM, Nakada-Tsukui K, Nozaki T.

Front Microbiol. 2015 May 5;6:354. doi: 10.3389/fmicb.2015.00354. eCollection 2015.


Nitazoxanide: nematicidal mode of action and drug combination studies.

Somvanshi VS, Ellis BL, Hu Y, Aroian RV.

Mol Biochem Parasitol. 2014 Jan;193(1):1-8. doi: 10.1016/j.molbiopara.2013.12.002. Epub 2014 Jan 8.


Transcriptome profiling of Giardia intestinalis using strand-specific RNA-seq.

Franzén O, Jerlström-Hultqvist J, Einarsson E, Ankarklev J, Ferella M, Andersson B, Svärd SG.

PLoS Comput Biol. 2013;9(3):e1003000. doi: 10.1371/journal.pcbi.1003000. Epub 2013 Mar 28.


Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia.

Tejman-Yarden N, Millman M, Lauwaet T, Davids BJ, Gillin FD, Dunn L, Upcroft JA, Miyamoto Y, Eckmann L.

Antimicrob Agents Chemother. 2011 Oct;55(10):4643-51. doi: 10.1128/AAC.00384-11. Epub 2011 Aug 8.


A comparison of the Giardia lamblia trophozoite and cyst transcriptome using microarrays.

Faghiri Z, Widmer G.

BMC Microbiol. 2011 May 4;11:91. doi: 10.1186/1471-2180-11-91.


A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with Giardia duodenalis.

Solaymani-Mohammadi S, Genkinger JM, Loffredo CA, Singer SM.

PLoS Negl Trop Dis. 2010 May 11;4(5):e682. doi: 10.1371/journal.pntd.0000682.


Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.

Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L.

J Med Chem. 2009 Jul 9;52(13):4038-53. doi: 10.1021/jm900356n.


Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases).

Pal D, Banerjee S, Cui J, Schwartz A, Ghosh SK, Samuelson J.

Antimicrob Agents Chemother. 2009 Feb;53(2):458-64. doi: 10.1128/AAC.00909-08. Epub 2008 Nov 17.

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