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Items: 1 to 20 of 197

1.

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, Maher R, Pronier E, Meyer SC, Garrett-Bakelman FE, Tallman M, Melnick A, Levine RL, Shih AH.

Cancer Cell. 2018 Jan 8;33(1):44-59.e8. doi: 10.1016/j.ccell.2017.11.012. Epub 2017 Dec 21.

PMID:
29275866
2.

SP174 Antibody Lacks Specificity for NRAS Q61R and Cross-Reacts With HRAS and KRAS Q61R Mutant Proteins in Malignant Melanoma.

Felisiak-Goląbek A, Inaguma S, Kowalik A, Wasąg B, Wang ZF, Zięba S, Pięciak L, Ryś J, Kopczynski J, Sarlomo-Rikala M, Góźdź S, Lasota J, Miettinen M.

Appl Immunohistochem Mol Morphol. 2018 Jan;26(1):40-45. doi: 10.1097/PAI.0000000000000500.

PMID:
29206715
3.

Different effection of p.1125Val>Ala and rs11954856 in APC on Wnt signaling pathway.

Li FF, Zhao ZX, Yan P, Wang S, Liu Z, Zhang Q, Zhang XN, Sun CH, Wang XS, Wang GY, Liu SL.

Oncotarget. 2017 Aug 5;8(41):70854-70864. doi: 10.18632/oncotarget.20106. eCollection 2017 Sep 19.

4.

The construction of intrahepatic cholangiocarcinoma model in zebrafish.

Wang J, Leng X, Wang G, Wan X, Cao H.

Sci Rep. 2017 Oct 17;7(1):13419. doi: 10.1038/s41598-017-13815-0.

5.

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.

Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ.

Sci Signal. 2017 Sep 26;10(498). pii: eaao3332. doi: 10.1126/scisignal.aao3332.

PMID:
28951536
6.

RAS Proteins and Their Regulators in Human Disease.

Simanshu DK, Nissley DV, McCormick F.

Cell. 2017 Jun 29;170(1):17-33. doi: 10.1016/j.cell.2017.06.009. Review.

PMID:
28666118
7.

NRAS mutations in cutaneous T cell lymphoma (CTCL) sensitize tumors towards treatment with the multikinase inhibitor Sorafenib.

Kießling MK, Nicolay JP, Schlör T, Klemke CD, Süss D, Krammer PH, Gülow K.

Oncotarget. 2017 Jul 11;8(28):45687-45697. doi: 10.18632/oncotarget.17669.

8.

Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells.

Chiou GY, Yang TW, Huang CC, Tang CY, Yen JY, Tsai MC, Chen HY, Fadhilah N, Lin CC, Jong YJ.

Sci Rep. 2017 May 19;7(1):2172. doi: 10.1038/s41598-017-02057-9.

9.

Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway.

Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor SK, Stenvall CA, Fortelius LE, Bergström LK, Sahlgren C, Toivola DM.

Cell Death Differ. 2017 Jun;24(6):984-996. doi: 10.1038/cdd.2017.28. Epub 2017 May 5.

10.

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.

Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera FJ, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH.

Nat Biotechnol. 2017 Jun;35(6):569-576. doi: 10.1038/nbt.3836. Epub 2017 May 1. Erratum in: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.

11.

DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer.

Takane K, Akagi K, Fukuyo M, Yagi K, Takayama T, Kaneda A.

Cancer Med. 2017 May;6(5):1023-1035. doi: 10.1002/cam4.1061. Epub 2017 Apr 4.

12.

No back seat for a progression event-K-RAS as a therapeutic target in CRC.

Poulin EJ, Haigis KM.

Genes Dev. 2017 Feb 15;31(4):333-335. doi: 10.1101/gad.297630.117. Epub 2017 Mar 17. Review.

13.

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.

Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S.

Nat Commun. 2017 Feb 21;8:14294. doi: 10.1038/ncomms14294.

14.

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K.

Cell. 2017 Feb 23;168(5):817-829.e15. doi: 10.1016/j.cell.2017.01.020. Epub 2017 Feb 16.

PMID:
28215705
15.

Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis.

Furlan D, Trapani D, Berrino E, Debernardi C, Panero M, Libera L, Sahnane N, Riva C, Tibiletti MG, Sessa F, Sapino A, Venesio T.

Br J Cancer. 2017 Mar 14;116(6):793-801. doi: 10.1038/bjc.2017.9. Epub 2017 Jan 31.

PMID:
28141798
16.

Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies.

Françoso A, Simioni PU.

Drug Des Devel Ther. 2017 Jan 11;11:177-184. doi: 10.2147/DDDT.S119036. eCollection 2017. Review.

17.

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.

Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM.

J Clin Invest. 2017 Feb 1;127(2):593-607. doi: 10.1172/JCI87588. Epub 2017 Jan 17.

18.

p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.

Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J.

Blood. 2017 Jan 19;129(3):358-370. doi: 10.1182/blood-2016-06-719237. Epub 2016 Nov 4.

19.
20.

Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.

Simmons AJ, Scurrah CR, McKinley ET, Herring CA, Irish JM, Washington MK, Coffey RJ, Lau KS.

Sci Signal. 2016 Oct 11;9(449):rs11.

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