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Items: 1 to 20 of 53


Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening.

Gage ZO, Vasou A, Gray DW, Randall RE, Adamson CS.

J Biomol Screen. 2016 Oct;21(9):978-88. doi: 10.1177/1087057116656314. Epub 2016 Jun 29.


Diaphorase Coupling Protocols for Red-Shifting Dehydrogenase Assays.

Davis MI, Shen M, Simeonov A, Hall MD.

Assay Drug Dev Technol. 2016 Apr;14(3):207-12. doi: 10.1089/adt.2016.706.


Avoiding Fluorescence Assay Interference-The Case for Diaphorase.

Hall MD, Simeonov A, Davis MI.

Assay Drug Dev Technol. 2016 Apr;14(3):175-9. doi: 10.1089/adt.2016.707. Review.


Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.

Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ.

Curr Protoc Chem Biol. 2012;4:177-191. Epub 2012 Sep 1.


A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.

Bernstock JD, Lee YJ, Peruzzotti-Jametti L, Southall N, Johnson KR, Maric D, Volpe G, Kouznetsova J, Zheng W, Pluchino S, Hallenbeck JM.

J Cereb Blood Flow Metab. 2016 Feb;36(2):426-41. doi: 10.1177/0271678X15609939. Epub 2015 Oct 23.


New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories.

Tewson PH, Martinka S, Shaner NC, Hughes TE, Quinn AM.

J Biomol Screen. 2016 Mar;21(3):298-305. doi: 10.1177/1087057115618608. Epub 2015 Dec 11.


Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.

Malfacini D, Ambrosio C, Gro' MC, Sbraccia M, Trapella C, Guerrini R, Bonora M, Pinton P, Costa T, Calo' G.

PLoS One. 2015 Aug 6;10(8):e0132865. doi: 10.1371/journal.pone.0132865. eCollection 2015 Aug 6.


Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds.

Lang L, Ding HF, Chen X, Sun SY, Liu G, Yan C.

Chem Biol. 2015 Jul 23;22(7):957-64. doi: 10.1016/j.chembiol.2015.06.009. Epub 2015 Jul 2.


PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL.

Nat Struct Mol Biol. 2015 May;22(5):362-9. doi: 10.1038/nsmb.3014. Epub 2015 Apr 20.


A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.

Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2553-67. doi: 10.1167/iovs.14-16298.


PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

Dahlin JL, Nissink JW, Strasser JM, Francis S, Higgins L, Zhou H, Zhang Z, Walters MA.

J Med Chem. 2015 Mar 12;58(5):2091-113. doi: 10.1021/jm5019093. Epub 2015 Feb 21.


Microcontroller-assisted compensation of adenosine triphosphate levels: instrument and method development.

Hu JB, Chen TR, Chen YC, Urban PL.

Sci Rep. 2015 Jan 30;5:8135. doi: 10.1038/srep08135.


The essential roles of chemistry in high-throughput screening triage.

Dahlin JL, Walters MA.

Future Med Chem. 2014 Jul;6(11):1265-90. doi: 10.4155/fmc.14.60. Review.


A chemical screen identifies small molecules that regulate hepcidin expression.

Gaun V, Patchen B, Volovetz J, Zhen AW, Andreev A, Pollastri MP, Fraenkel PG.

Blood Cells Mol Dis. 2014 Dec;53(4):231-40. doi: 10.1016/j.bcmd.2014.06.002. Epub 2014 Jul 4.


The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

Evans SE, Goult BT, Fairall L, Jamieson AG, Ko Ferrigno P, Ford R, Schwabe JW, Wagner SD.

PLoS One. 2014 Mar 4;9(3):e90889. doi: 10.1371/journal.pone.0090889. eCollection 2014 Mar 4.


A novel aromatic carboxylic acid inactivates luciferase by acylation of an enzymatically active regulatory lysine residue.

Nakagomi M, Fujimaki N, Ito A, Toda T, Fukasawa H, Shudo K, Tomita R.

PLoS One. 2013 Sep 16;8(9):e75445. doi: 10.1371/journal.pone.0075445. eCollection 2013 Sep 16.


Identification of a new class of small molecules that efficiently reactivate latent Epstein-Barr Virus.

Tikhmyanova N, Schultz DC, Lee T, Salvino JM, Lieberman PM.

ACS Chem Biol. 2014 Mar 21;9(3):785-95. doi: 10.1021/cb4006326. Epub 2014 Feb 19.


High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant non-small cell lung cancer.

Bennett DC, Charest J, Sebolt K, Lehrman M, Rehemtulla A, Contessa JN.

Transl Oncol. 2013 Jun 1;6(3):382-91. Print 2013 Jun.

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