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PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity.

Arun RP, Sivanesan D, Vidyasekar P, Verma RS.

Sci Rep. 2017 Jul 20;7(1):5952. doi: 10.1038/s41598-017-06416-4.


PTEN, Longevity and Age-Related Diseases.

Tait IS, Li Y, Lu J.

Biomedicines. 2013 Dec 13;1(1):17-48. doi: 10.3390/biomedicines1010017. Review.


Anti-diabetic effect of Alpinia oxyphylla extract on 57BL/KsJ db-/db- mice.

Xie Y, Xiao M, Li D, Liu H, Yun F, Wei Y, Sang S, Du G.

Exp Ther Med. 2017 Apr;13(4):1321-1328. doi: 10.3892/etm.2017.4152. Epub 2017 Feb 22.


Establishment of a novel cellular model for myxofibrosarcoma heterogeneity.

Lohberger B, Stuendl N, Leithner A, Rinner B, Sauer S, Kashofer K, Liegl-Atzwanger B.

Sci Rep. 2017 Mar 17;7:44700. doi: 10.1038/srep44700.


Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.

Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT.

Nat Commun. 2017 Jan 17;8:14013. doi: 10.1038/ncomms14013. Erratum in: Nat Commun. 2017 Aug 14;8:15795.


Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas.

Vidimar V, Gius D, Chakravarti D, Bulun SE, Wei JJ, Kim JJ.

Sci Adv. 2016 Nov 4;2(11):e1601132. eCollection 2016 Nov.


Does PTEN gene mutation play any role in Li-Fraumeni syndrome.

Akouchekian M, Hemati S, Jafari D, Jalilian N, Dehghan Manshadi M.

Med J Islam Repub Iran. 2016 May 29;30:378. eCollection 2016.


Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.

Zhang C, Jia X, Bao J, Chen S, Wang K, Zhang Y, Li P, Wan JB, Su H, Wang Y, Mei Z, He C.

BMC Complement Altern Med. 2016 Feb 9;16:58. doi: 10.1186/s12906-016-1036-x.


The Optimization of Soluble PTEN Expression in Escherichia coli.

Hu Y, An Y, Fang N, Li Y, Jin H, Nazarali A, Ji S.

Open Biochem J. 2015 Aug 21;9:42-8. doi: 10.2174/1874091X01509010042. eCollection 2015.


A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

Gil A, Rodríguez-Escudero I, Stumpf M, Molina M, Cid VJ, Pulido R.

PLoS One. 2015 Apr 15;10(4):e0119287. doi: 10.1371/journal.pone.0119287. eCollection 2015.


ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells.

Chen JH, Zhang P, Chen WD, Li DD, Wu XQ, Deng R, Jiao L, Li X, Ji J, Feng GK, Zeng YX, Jiang JW, Zhu XF.

Autophagy. 2015;11(2):239-52. doi: 10.1080/15548627.2015.1009767.


Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS.

J Biol Chem. 2015 Mar 13;290(11):7141-50. doi: 10.1074/jbc.M114.613687. Epub 2015 Jan 28.


Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.

Minami A, Nakanishi A, Ogura Y, Kitagishi Y, Matsuda S.

Front Oncol. 2014 Nov 10;4:318. doi: 10.3389/fonc.2014.00318. eCollection 2014. Review.


PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.

Qi Y, Liu J, Saadat S, Tian X, Han Y, Fong GH, Pandolfi PP, Lee LY, Li S.

Cell Death Differ. 2015 May;22(5):875-84. doi: 10.1038/cdd.2014.185. Epub 2014 Nov 14.


Hypoxic culture conditions enhance the generation of regulatory T cells.

Neildez-Nguyen TM, Bigot J, Da Rocha S, Corre G, Boisgerault F, Paldi A, Galy A.

Immunology. 2015 Mar;144(3):431-443. doi: 10.1111/imm.12388.


Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation.

Yu W, He X, Ni Y, Ngeow J, Eng C.

Hum Mol Genet. 2015 Jan 1;24(1):142-53. doi: 10.1093/hmg/ddu425. Epub 2014 Aug 22.


Loss of nuclear PTEN in HCV-infected human hepatocytes.

Bao W, Florea L, Wu N, Wang Z, Banaudha K, Qian J, Houzet L, Kumar R, Kumar A.

Infect Agent Cancer. 2014 Jul 18;9:23. doi: 10.1186/1750-9378-9-23. eCollection 2014.


Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.

Silva AR, Santos AC, Farfel JM, Grinberg LT, Ferretti RE, Campos AH, Cunha IW, Begnami MD, Rocha RM, Carraro DM, de Bragança Pereira CA, Jacob-Filho W, Brentani H.

PLoS One. 2014 Jun 17;9(6):e99897. doi: 10.1371/journal.pone.0099897. eCollection 2014.


MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation.

Wu MH, Chen YA, Chen HH, Chang KW, Chang IS, Wang LH, Hsu HL.

Oncogene. 2014 Oct 23;33(43):5109-20. doi: 10.1038/onc.2014.125. Epub 2014 May 26.


PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms.

Briest F, Grabowski P.

Theranostics. 2014 Jan 29;4(4):336-65. doi: 10.7150/thno.7851. eCollection 2014. Review.

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