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Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance.

Boehme KA, Schleicher SB, Traub F, Rolauffs B.

Int J Mol Sci. 2018 Jan 21;19(1). pii: E311. doi: 10.3390/ijms19010311. Review.


Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.

Thorpe SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A, Knight MM.

J Cell Physiol. 2017 Sep;232(9):2407-2417. doi: 10.1002/jcp.25839. Epub 2017 Mar 31.


Primary Cilia and Intraflagellar Transport Proteins in Bone and Cartilage.

Yuan X, Yang S.

J Dent Res. 2016 Nov;95(12):1341-1349. doi: 10.1177/0022034516652383. Epub 2016 Jul 20. Review.


Measuring the primary cilium length: improved method for unbiased high-throughput analysis.

Dummer A, Poelma C, DeRuiter MC, Goumans MJ, Hierck BP.

Cilia. 2016 Feb 11;5:7. doi: 10.1186/s13630-016-0028-2. eCollection 2016.


New therapeutic targets in rare genetic skeletal diseases.

Briggs MD, Bell PA, Wright MJ, Pirog KA.

Expert Opin Orphan Drugs. 2015 Oct 3;3(10):1137-1154. Epub 2015 Sep 24.


IFT88 influences chondrocyte actin organization and biomechanics.

Wang Z, Wann AK, Thompson CL, Hassen A, Wang W, Knight MM.

Osteoarthritis Cartilage. 2016 Mar;24(3):544-54. doi: 10.1016/j.joca.2015.10.003. Epub 2015 Oct 19.


Targeted In Situ Biosynthetic Transcriptional Activation in Native Surface-Level Human Articular Chondrocytes during Lesion Stabilization.

Ganguly K, McRury ID, Goodwin PM, Morgan RE, Augé WK 2nd.

Cartilage. 2012 Apr;3(2):141-55. doi: 10.1177/1947603511426881.


Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.

Nygaard MB, Almstrup K, Lindbæk L, Christensen ST, Svingen T.

Sci Rep. 2015 May 20;5:10364. doi: 10.1038/srep10364.


Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer's vesicle.

Verleyen D, Luyten FP, Tylzanowski P.

PLoS One. 2014 Oct 21;9(10):e110484. doi: 10.1371/journal.pone.0110484. eCollection 2014.


Primary cilia in the developing pig testis.

Ou Y, Dores C, Rodriguez-Sosa JR, van der Hoorn FA, Dobrinski I.

Cell Tissue Res. 2014 Nov;358(2):597-605. doi: 10.1007/s00441-014-1973-y. Epub 2014 Aug 9.


Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton.

Yuan X, Serra RA, Yang S.

Ann N Y Acad Sci. 2015 Jan;1335:78-99. doi: 10.1111/nyas.12463. Epub 2014 Jun 24. Review.


Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.

Joiner DM, Less KD, Van Wieren EM, Zhang YW, Hess D, Williams BO.

Arthritis Res Ther. 2014 Mar 27;16(2):R81. doi: 10.1186/ar4522.


Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.

Thompson CL, Chapple JP, Knight MM.

Osteoarthritis Cartilage. 2014 Mar;22(3):490-8. doi: 10.1016/j.joca.2013.12.016. Epub 2014 Jan 21.


Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage.

Irianto J, Ramaswamy G, Serra R, Knight MM.

J Biomech. 2014 Jan 22;47(2):579-82. doi: 10.1016/j.jbiomech.2013.11.040. Epub 2013 Dec 4.


Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.

Wann AK, Thompson CL, Chapple JP, Knight MM.

Cilia. 2013 Dec 13;2(1):17. doi: 10.1186/2046-2530-2-17.


The bovine patella as a model of early osteoarthritis.

Hargrave-Thomas EJ, Thambyah A, McGlashan SR, Broom ND.

J Anat. 2013 Dec;223(6):651-64. doi: 10.1111/joa.12115. Epub 2013 Sep 20.


Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis.

Houard X, Goldring MB, Berenbaum F.

Curr Rheumatol Rep. 2013 Nov;15(11):375. doi: 10.1007/s11926-013-0375-6. Review.


Development of a method for the measurement of primary cilia length in 3D.

Saggese T, Young AA, Huang C, Braeckmans K, McGlashan SR.

Cilia. 2012 Jul 3;1(1):11. doi: 10.1186/2046-2530-1-11.


IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways.

Wang C, Yuan X, Yang S.

Exp Cell Res. 2013 Mar 10;319(5):623-32. doi: 10.1016/j.yexcr.2012.12.028. Epub 2013 Jan 16.

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